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Filarial antigenemia and Loa loa night blood microfilaremia in an area without bancroftian filariasis in the Democratic Republic of Congo.

Bakajika DK, Nigo MM, Lotsima JP, Masikini GA, Fischer K, Lloyd MM, Weil GJ, Fischer PU - Am. J. Trop. Med. Hyg. (2014)

Bottom Line: Filarial antigenemia rates by card test exceeded 1% in 28 villages (range = 0-14%).Filarial antigen positivity was strongly associated with high L. loa Mf counts.Periodicity studies revealed atypical patterns, with no significant diurnal periodicity in some individuals.

View Article: PubMed Central - PubMed

Affiliation: Programme National de Lutte contre L'Onchocercose, Kinshasa, Democratic Republic of Congo; Centre de Recherche en Maladies Tropicales de l'Ituri, Ituri, Congo, Democratic Republic of Congo; Infectious Diseases Division, Department of Internal Medicine, Washington University School of Medicine, St. Louis, Missouri.

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Map of (left panel) the study area in the northeastern DRC showing (right panel) the examined villages in the Mambasa and Watsa Territories.
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Figure 1: Map of (left panel) the study area in the northeastern DRC showing (right panel) the examined villages in the Mambasa and Watsa Territories.

Mentions: In total, 14 villages in the Ituri region (Mambasa Territory) and 16 villages in the Haut Uele region (Watsa Territory) of the Orientale Province in the eastern Democratic Republic of Congo (DRC) (Figure 1 and Supplemental Table 1) were screened for Mf and filarial antigenemia. Most villages were located in remote forested areas east of the Okapi game reserve. The surveys were conducted in July of 2011 and January of 2013. No community-directed treatment with ivermectin had been performed in the study areas before these surveys. Historically the Ituri region has been reported to be endemic for L. loa, W. bancrofti, and M. perstans (with Mf in the blood) as well as Onchocerca volvulus and M. streptocerca (with Mf in skin).3 More recent rapid epidemiological mapping of onchocerciasis indicated mostly meso- and hyperendemic villages in Mambasa and lower endemicity in Watsa.4


Filarial antigenemia and Loa loa night blood microfilaremia in an area without bancroftian filariasis in the Democratic Republic of Congo.

Bakajika DK, Nigo MM, Lotsima JP, Masikini GA, Fischer K, Lloyd MM, Weil GJ, Fischer PU - Am. J. Trop. Med. Hyg. (2014)

Map of (left panel) the study area in the northeastern DRC showing (right panel) the examined villages in the Mambasa and Watsa Territories.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4257636&req=5

Figure 1: Map of (left panel) the study area in the northeastern DRC showing (right panel) the examined villages in the Mambasa and Watsa Territories.
Mentions: In total, 14 villages in the Ituri region (Mambasa Territory) and 16 villages in the Haut Uele region (Watsa Territory) of the Orientale Province in the eastern Democratic Republic of Congo (DRC) (Figure 1 and Supplemental Table 1) were screened for Mf and filarial antigenemia. Most villages were located in remote forested areas east of the Okapi game reserve. The surveys were conducted in July of 2011 and January of 2013. No community-directed treatment with ivermectin had been performed in the study areas before these surveys. Historically the Ituri region has been reported to be endemic for L. loa, W. bancrofti, and M. perstans (with Mf in the blood) as well as Onchocerca volvulus and M. streptocerca (with Mf in skin).3 More recent rapid epidemiological mapping of onchocerciasis indicated mostly meso- and hyperendemic villages in Mambasa and lower endemicity in Watsa.4

Bottom Line: Filarial antigenemia rates by card test exceeded 1% in 28 villages (range = 0-14%).Filarial antigen positivity was strongly associated with high L. loa Mf counts.Periodicity studies revealed atypical patterns, with no significant diurnal periodicity in some individuals.

View Article: PubMed Central - PubMed

Affiliation: Programme National de Lutte contre L'Onchocercose, Kinshasa, Democratic Republic of Congo; Centre de Recherche en Maladies Tropicales de l'Ituri, Ituri, Congo, Democratic Republic of Congo; Infectious Diseases Division, Department of Internal Medicine, Washington University School of Medicine, St. Louis, Missouri.

Show MeSH
Related in: MedlinePlus