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Serum OPN expression for identification of gastric cancer and atrophic gastritis and its influencing factors.

Chen T, Sun L, He C, Gong Y, Xu Q, Yuan Y - PLoS ONE (2014)

Bottom Line: OPN levels were significantly higher in patients with GC compared with the non-cancer population (2.17 ± 2.10, P < 0.0001).Serum OPN expression was closely related to the risks of GC and AG, and it might be a useful marker for the discrimination of GC.OPN level was positively correlated with age and male sex, but was not affected by H. pylori infection, and it was promoted by smoking and drinking, in patients with mild SG.

View Article: PubMed Central - PubMed

Affiliation: Tumor Etiology and Screening Department of Cancer Institute and General Surgery, the First Affiliated Hospital of China Medical University, and Key Laboratory of Cancer Etiology and Prevention (China Medical University), Liaoning Provincial Education Department, Shenyang 110001, China; Medical Oncology Department of Benxi Central Hospital, Benxi, China.

ABSTRACT

Background: Most studies have found that osteopontin (OPN) expression level is related to the poor prognosis of gastric cancer. However, few studies have examined the relationship between OPN expression and gastric precancerous diseases, and the potential role of OPN in the formation and development of GC. We investigated the relationships between serum OPN levels and the risks of gastric cancer (GC) and its precancerous disease, to explore the diagnostic efficacy of serum OPN level for GC and atrophic gastritis and its influencing factors.

Methods: A total of 1,452 patients were enrolled, including 609 with mild superficial gastritis (SG), 594 with atrophic gastritis (AG) and 249 with GC. The levels of serum OPN and serum Helicobacter pylori IgG antibody were detected by enzyme-linked immunosorbent assay.

Results: Serum OPN levels increased from mild SG (1.99 ± 1.91 ng/ml) to AG (2.37 ± 2.27 ng/ml) to GC (5.94 ± 4.52 ng/ml) (P ≤ 0.002), along with increasing severity of gastric disease. OPN levels were significantly higher in patients with GC compared with the non-cancer population (2.17 ± 2.10, P < 0.0001). Serum OPN level was positively correlated with age and was higher in men than women, but was not correlated with H. pylori infection status. The area under the receiver operating characteristic curve was 0.805, the optimal cutoff was 2.56 ng/ml and the sensitivity and specificity were 74.3% and 71.8%, respectively, for the ability of serum OPN to discriminate GC.

Conclusions: Serum OPN expression was closely related to the risks of GC and AG, and it might be a useful marker for the discrimination of GC. OPN level was positively correlated with age and male sex, but was not affected by H. pylori infection, and it was promoted by smoking and drinking, in patients with mild SG.

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Related in: MedlinePlus

Scatter plots for the correlation between serum OPN and gender, age, H. pylori infection, in gastric cancer group.A, Gender; B, Age; C, H.pylori infection.
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pone-0114005-g001: Scatter plots for the correlation between serum OPN and gender, age, H. pylori infection, in gastric cancer group.A, Gender; B, Age; C, H.pylori infection.

Mentions: Patients were stratified by age, sex or H. pylori infection status (Table 3, Figure 1). In any group, the correlation coefficient for OPN and age (R1) was significantly above the 0 level (P<0.016), and the correlation coefficient for OPN and gender (R2) was significantly lower than the 0 level (P<0.049), Serum OPN level was increased with the age of the patients, and was higher in male sex than female sex. While there was no definite correlation between H. pylori infection and serum OPN, for the correlation coefficients for OPN and H. pylori (R3) were discrepant (P>0.108). Comparisons of serum OPN levels between men and women and between patients aged ≤50 years and >50 years in each disease group (Table 4) showed much higher serum OPN levels in men than women (P<0.013), and in the >50 year-old group compared with the ≤50 year-old group (P<0.024). However, there were no significant differences between the H. pylori IgG (+) group and the H. pylori IgG (−) group (P>0.113). Furthermore, serum OPN levels were elevated in smokers and drinkers (P<0.001, and P = 0.002, respectively) in the mild SG group compared with non-smokers and non-drinkers, but this discrepancy was not found in either the AG or GC group.


Serum OPN expression for identification of gastric cancer and atrophic gastritis and its influencing factors.

Chen T, Sun L, He C, Gong Y, Xu Q, Yuan Y - PLoS ONE (2014)

Scatter plots for the correlation between serum OPN and gender, age, H. pylori infection, in gastric cancer group.A, Gender; B, Age; C, H.pylori infection.
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4257596&req=5

pone-0114005-g001: Scatter plots for the correlation between serum OPN and gender, age, H. pylori infection, in gastric cancer group.A, Gender; B, Age; C, H.pylori infection.
Mentions: Patients were stratified by age, sex or H. pylori infection status (Table 3, Figure 1). In any group, the correlation coefficient for OPN and age (R1) was significantly above the 0 level (P<0.016), and the correlation coefficient for OPN and gender (R2) was significantly lower than the 0 level (P<0.049), Serum OPN level was increased with the age of the patients, and was higher in male sex than female sex. While there was no definite correlation between H. pylori infection and serum OPN, for the correlation coefficients for OPN and H. pylori (R3) were discrepant (P>0.108). Comparisons of serum OPN levels between men and women and between patients aged ≤50 years and >50 years in each disease group (Table 4) showed much higher serum OPN levels in men than women (P<0.013), and in the >50 year-old group compared with the ≤50 year-old group (P<0.024). However, there were no significant differences between the H. pylori IgG (+) group and the H. pylori IgG (−) group (P>0.113). Furthermore, serum OPN levels were elevated in smokers and drinkers (P<0.001, and P = 0.002, respectively) in the mild SG group compared with non-smokers and non-drinkers, but this discrepancy was not found in either the AG or GC group.

Bottom Line: OPN levels were significantly higher in patients with GC compared with the non-cancer population (2.17 ± 2.10, P < 0.0001).Serum OPN expression was closely related to the risks of GC and AG, and it might be a useful marker for the discrimination of GC.OPN level was positively correlated with age and male sex, but was not affected by H. pylori infection, and it was promoted by smoking and drinking, in patients with mild SG.

View Article: PubMed Central - PubMed

Affiliation: Tumor Etiology and Screening Department of Cancer Institute and General Surgery, the First Affiliated Hospital of China Medical University, and Key Laboratory of Cancer Etiology and Prevention (China Medical University), Liaoning Provincial Education Department, Shenyang 110001, China; Medical Oncology Department of Benxi Central Hospital, Benxi, China.

ABSTRACT

Background: Most studies have found that osteopontin (OPN) expression level is related to the poor prognosis of gastric cancer. However, few studies have examined the relationship between OPN expression and gastric precancerous diseases, and the potential role of OPN in the formation and development of GC. We investigated the relationships between serum OPN levels and the risks of gastric cancer (GC) and its precancerous disease, to explore the diagnostic efficacy of serum OPN level for GC and atrophic gastritis and its influencing factors.

Methods: A total of 1,452 patients were enrolled, including 609 with mild superficial gastritis (SG), 594 with atrophic gastritis (AG) and 249 with GC. The levels of serum OPN and serum Helicobacter pylori IgG antibody were detected by enzyme-linked immunosorbent assay.

Results: Serum OPN levels increased from mild SG (1.99 ± 1.91 ng/ml) to AG (2.37 ± 2.27 ng/ml) to GC (5.94 ± 4.52 ng/ml) (P ≤ 0.002), along with increasing severity of gastric disease. OPN levels were significantly higher in patients with GC compared with the non-cancer population (2.17 ± 2.10, P < 0.0001). Serum OPN level was positively correlated with age and was higher in men than women, but was not correlated with H. pylori infection status. The area under the receiver operating characteristic curve was 0.805, the optimal cutoff was 2.56 ng/ml and the sensitivity and specificity were 74.3% and 71.8%, respectively, for the ability of serum OPN to discriminate GC.

Conclusions: Serum OPN expression was closely related to the risks of GC and AG, and it might be a useful marker for the discrimination of GC. OPN level was positively correlated with age and male sex, but was not affected by H. pylori infection, and it was promoted by smoking and drinking, in patients with mild SG.

Show MeSH
Related in: MedlinePlus