Population pharmacokinetic meta-analysis of vortioxetine in healthy individuals.
Bottom Line: CYP2D6 inferred metabolic status (ultra, extensive, intermediate or poor metabolisers) and age on oral clearance and height on central volume of distribution were identified as statistically significant covariate-parameter relationships.The final model was found to be reliable, stable and predictive.A reliable, stable and predictive pharmacokinetic model was developed to characterise pharmacokinetics of vortioxetine in the healthy population.
Affiliation: Division of Clinical and Quantitative Pharmacology, H. Lundbeck A/S, Valby, Denmark.Show MeSH
Mentions: The eta shrinkages for the final model were 22% (ka), 16% (V2/F) and 2% (CL/F). Epsilon shrinkage was 4%. According to the rule-of-thumb of 20–30% 12, a small degree of shrinkage was only found for ka. The VPC plot (fig. 5) showed that the observed values lay within the 95% confidence intervals. The estimated NPDE values followed an N(0,1) distribution.
Affiliation: Division of Clinical and Quantitative Pharmacology, H. Lundbeck A/S, Valby, Denmark.