Population pharmacokinetic meta-analysis of vortioxetine in healthy individuals.
Bottom Line: The objective was to describe the pharmacokinetics of vortioxetine and evaluate the effect of intrinsic and extrinsic factors in the healthy population.The final model was found to be reliable, stable and predictive.A reliable, stable and predictive pharmacokinetic model was developed to characterise pharmacokinetics of vortioxetine in the healthy population.
Affiliation: Division of Clinical and Quantitative Pharmacology, H. Lundbeck A/S, Valby, Denmark.Show MeSH
Mentions: The eta shrinkages for the final model were 22% (ka), 16% (V2/F) and 2% (CL/F). Epsilon shrinkage was 4%. According to the rule-of-thumb of 20–30% 12, a small degree of shrinkage was only found for ka. The VPC plot (fig. 5) showed that the observed values lay within the 95% confidence intervals. The estimated NPDE values followed an N(0,1) distribution.
Affiliation: Division of Clinical and Quantitative Pharmacology, H. Lundbeck A/S, Valby, Denmark.