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Role of medio-dorsal frontal and posterior parietal neurons during auditory detection performance in rats.

Bohon KS, Wiest MC - PLoS ONE (2014)

Bottom Line: To further characterize the role of frontal and parietal cortices in rat cognition, we recorded action potentials simultaneously from multiple sites in the medio-dorsal frontal cortex and posterior parietal cortex of rats while they performed a two-choice auditory detection task.We quantified neural correlates of task performance, including response movements, perception of a target tone, and the differentiation between stimuli with distinct features (different pitches or durations).In addition, we found a smaller and mostly not overlapping population of units that differentiated stimuli based on task-irrelevant details.

View Article: PubMed Central - PubMed

Affiliation: Wellesley College Neuroscience Program, Wellesley, Massachusetts, United States of America.

ABSTRACT
To further characterize the role of frontal and parietal cortices in rat cognition, we recorded action potentials simultaneously from multiple sites in the medio-dorsal frontal cortex and posterior parietal cortex of rats while they performed a two-choice auditory detection task. We quantified neural correlates of task performance, including response movements, perception of a target tone, and the differentiation between stimuli with distinct features (different pitches or durations). A minority of units--15% in frontal cortex, 23% in parietal cortex--significantly distinguished hit trials (successful detections, response movement to the right) from correct rejection trials (correct leftward response to the absence of the target tone). Estimating the contribution of movement-related activity to these responses suggested that more than half of these units were likely signaling correct perception of the auditory target, rather than merely movement direction. In addition, we found a smaller and mostly not overlapping population of units that differentiated stimuli based on task-irrelevant details. The detection-related spiking responses we observed suggest that correlates of perception in the rat are sparsely represented among neurons in the rat's frontal-parietal network, without being concentrated preferentially in frontal or parietal areas.

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Choice probability distributions calculated in a 250 ms post-stimulus time bin from example trial-subsamples of all 195 frontal (left) and all 349 parietal (right) units of our reduced data set, using a 250 ms post-stimulus time bin. Conventions as in Figure 3.
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pone-0114064-g004: Choice probability distributions calculated in a 250 ms post-stimulus time bin from example trial-subsamples of all 195 frontal (left) and all 349 parietal (right) units of our reduced data set, using a 250 ms post-stimulus time bin. Conventions as in Figure 3.

Mentions: Indeed the frontal estimate of the fraction of PPUs estimated using a 250 ms window is consistent with the fraction expected from chance fluctuations in the PSTHs. Still, as shown in Figure 4, the existence of some units with relatively large CPs suggests that at least some of the PPUs based on the 250 ms analysis are genuinely signaling perception rather than representing statistical fluctuations. Consistent with this interpretation, in the 250 ms analysis, a much smaller fraction of the CPUs were consistent with a motor-related function, as might be expected in the earlier time window (Figure 4).


Role of medio-dorsal frontal and posterior parietal neurons during auditory detection performance in rats.

Bohon KS, Wiest MC - PLoS ONE (2014)

Choice probability distributions calculated in a 250 ms post-stimulus time bin from example trial-subsamples of all 195 frontal (left) and all 349 parietal (right) units of our reduced data set, using a 250 ms post-stimulus time bin. Conventions as in Figure 3.
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4257565&req=5

pone-0114064-g004: Choice probability distributions calculated in a 250 ms post-stimulus time bin from example trial-subsamples of all 195 frontal (left) and all 349 parietal (right) units of our reduced data set, using a 250 ms post-stimulus time bin. Conventions as in Figure 3.
Mentions: Indeed the frontal estimate of the fraction of PPUs estimated using a 250 ms window is consistent with the fraction expected from chance fluctuations in the PSTHs. Still, as shown in Figure 4, the existence of some units with relatively large CPs suggests that at least some of the PPUs based on the 250 ms analysis are genuinely signaling perception rather than representing statistical fluctuations. Consistent with this interpretation, in the 250 ms analysis, a much smaller fraction of the CPUs were consistent with a motor-related function, as might be expected in the earlier time window (Figure 4).

Bottom Line: To further characterize the role of frontal and parietal cortices in rat cognition, we recorded action potentials simultaneously from multiple sites in the medio-dorsal frontal cortex and posterior parietal cortex of rats while they performed a two-choice auditory detection task.We quantified neural correlates of task performance, including response movements, perception of a target tone, and the differentiation between stimuli with distinct features (different pitches or durations).In addition, we found a smaller and mostly not overlapping population of units that differentiated stimuli based on task-irrelevant details.

View Article: PubMed Central - PubMed

Affiliation: Wellesley College Neuroscience Program, Wellesley, Massachusetts, United States of America.

ABSTRACT
To further characterize the role of frontal and parietal cortices in rat cognition, we recorded action potentials simultaneously from multiple sites in the medio-dorsal frontal cortex and posterior parietal cortex of rats while they performed a two-choice auditory detection task. We quantified neural correlates of task performance, including response movements, perception of a target tone, and the differentiation between stimuli with distinct features (different pitches or durations). A minority of units--15% in frontal cortex, 23% in parietal cortex--significantly distinguished hit trials (successful detections, response movement to the right) from correct rejection trials (correct leftward response to the absence of the target tone). Estimating the contribution of movement-related activity to these responses suggested that more than half of these units were likely signaling correct perception of the auditory target, rather than merely movement direction. In addition, we found a smaller and mostly not overlapping population of units that differentiated stimuli based on task-irrelevant details. The detection-related spiking responses we observed suggest that correlates of perception in the rat are sparsely represented among neurons in the rat's frontal-parietal network, without being concentrated preferentially in frontal or parietal areas.

Show MeSH
Related in: MedlinePlus