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The Utility of Diffusion Weighted Imaging (DWI) Using Apparent Diffusion Coefficient (ADC) Values in Discriminating Between Prostate Cancer and Normal Tissue.

Luczyńska E, Heinze-Paluchowska S, Domalik A, Cwierz A, Kasperkiewicz H, Blecharz P, Jereczek-Fossa B - Pol J Radiol (2014)

Bottom Line: Mean ADC values for patients with low, intermediate and high GS were 0.85±0.03, 0.72±0.03, and 0.61±0.04, respectively.DWI/ADC is useful in differentiating high-risk patients from those at low and intermediate risk, since there is a significant correlation between ADC values determined in patients included in three different groups according to their Gleason score.This information may be helpful in the assessment of prostate cancer aggressiveness.

View Article: PubMed Central - PubMed

Affiliation: Department of Radiology, Centre of Oncology, Maria Sklodowska-Curie Memorial Institute of Oncology, Cracow, Poland.

ABSTRACT

Background: The aim of this study was to investigate the utility of diffusion weighted imaging (DWI) using Apparent Diffusion Coefficient (ADC) values in discriminating between patients with tumors and normal prostate tissue before the initial systematic core biopsy. The relationship between histological grade of prostate cancer and ADC values in the peripheral zone was also investigated.

Material/methods: Our study included 62 patients who underwent magnetic resonance imaging (MRI) of the pelvis. The examinations were performed in T1-, T2-weighted, DWI and T1 after dynamic contrast administration sequences. In all patients there were abnormal foci within the peripheral zone determined in DWI/ADC. ADC values were compared with the Gleason score (GS) after core needle biopsy (CNB) in patients with low, medium and high stage tumors.

Results: Within the examined group of patients, ADC was statistically higher for normal tissue than for cancerous tissue (p=0.00). Mean ADC values for patients with low, intermediate and high GS were 0.85±0.03, 0.72±0.03, and 0.61±0.04, respectively.

Conclusions: DWI/ADC is useful in differentiating high-risk patients from those at low and intermediate risk, since there is a significant correlation between ADC values determined in patients included in three different groups according to their Gleason score. This information may be helpful in the assessment of prostate cancer aggressiveness.

No MeSH data available.


Related in: MedlinePlus

A 66-year-old man with PSA of 12.1 ng/mL; (A) T2-weighted transversal image shows a hypo-intense nodule in the right lateral peripheral zone, indicative of malignancy; (B) DWI with b=800; (C) ADC map: in the peripheral zone, on the right side, a dark area is visible (value of 0.82 mm2/s).
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Related In: Results  -  Collection


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f2-poljradiol-79-450: A 66-year-old man with PSA of 12.1 ng/mL; (A) T2-weighted transversal image shows a hypo-intense nodule in the right lateral peripheral zone, indicative of malignancy; (B) DWI with b=800; (C) ADC map: in the peripheral zone, on the right side, a dark area is visible (value of 0.82 mm2/s).

Mentions: All MRI examinations were performed with a 1.5-T magnet (Avanto; Siemens, Erlangen, Germany) by using the multichannel body matrix phased-array coil. The examinations were performed in T1-WI, T2-WI, DWI and T1-weighted sequences after dynamic contrast administration. ADCs were calculated from transverse DWI obtained by using a single-shot echo-planar imaging sequence with the following parameters: TR/TE: 3400/75 ms and b values of 0, 100, 300, 800 and 1000 sec/mm2. Full echo information was obtained with a bandwidth of 1220 Hz/pixel and a matrix size of 256×256. The field of view was 220 mm, with 4-mm section thickness and no intersection gap, covering the entire prostate and seminal vesicles. T1-WI images were assessed to exclude bleeding signs among patients. Prostate cancer was diagnosed in T2-weighted images, dynamic contrast-enhanced MRI and DWI according to standard criteria, and lesion location was determined in accordance with the biopsy result as a golden standard. In MRI, lesions considered as prostate cancer complied with the following criteria: in T2-weighted images, round, oval, or triangular lesions with a low signal intensity in the peripheral zone, in DWI examinations – areas with a higher signal intensity than that surrounding the peripheral zone and a low-signal-intensity area in ADC examination (Figures 1 and 2).


The Utility of Diffusion Weighted Imaging (DWI) Using Apparent Diffusion Coefficient (ADC) Values in Discriminating Between Prostate Cancer and Normal Tissue.

Luczyńska E, Heinze-Paluchowska S, Domalik A, Cwierz A, Kasperkiewicz H, Blecharz P, Jereczek-Fossa B - Pol J Radiol (2014)

A 66-year-old man with PSA of 12.1 ng/mL; (A) T2-weighted transversal image shows a hypo-intense nodule in the right lateral peripheral zone, indicative of malignancy; (B) DWI with b=800; (C) ADC map: in the peripheral zone, on the right side, a dark area is visible (value of 0.82 mm2/s).
© Copyright Policy - open-access
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC4257483&req=5

f2-poljradiol-79-450: A 66-year-old man with PSA of 12.1 ng/mL; (A) T2-weighted transversal image shows a hypo-intense nodule in the right lateral peripheral zone, indicative of malignancy; (B) DWI with b=800; (C) ADC map: in the peripheral zone, on the right side, a dark area is visible (value of 0.82 mm2/s).
Mentions: All MRI examinations were performed with a 1.5-T magnet (Avanto; Siemens, Erlangen, Germany) by using the multichannel body matrix phased-array coil. The examinations were performed in T1-WI, T2-WI, DWI and T1-weighted sequences after dynamic contrast administration. ADCs were calculated from transverse DWI obtained by using a single-shot echo-planar imaging sequence with the following parameters: TR/TE: 3400/75 ms and b values of 0, 100, 300, 800 and 1000 sec/mm2. Full echo information was obtained with a bandwidth of 1220 Hz/pixel and a matrix size of 256×256. The field of view was 220 mm, with 4-mm section thickness and no intersection gap, covering the entire prostate and seminal vesicles. T1-WI images were assessed to exclude bleeding signs among patients. Prostate cancer was diagnosed in T2-weighted images, dynamic contrast-enhanced MRI and DWI according to standard criteria, and lesion location was determined in accordance with the biopsy result as a golden standard. In MRI, lesions considered as prostate cancer complied with the following criteria: in T2-weighted images, round, oval, or triangular lesions with a low signal intensity in the peripheral zone, in DWI examinations – areas with a higher signal intensity than that surrounding the peripheral zone and a low-signal-intensity area in ADC examination (Figures 1 and 2).

Bottom Line: Mean ADC values for patients with low, intermediate and high GS were 0.85±0.03, 0.72±0.03, and 0.61±0.04, respectively.DWI/ADC is useful in differentiating high-risk patients from those at low and intermediate risk, since there is a significant correlation between ADC values determined in patients included in three different groups according to their Gleason score.This information may be helpful in the assessment of prostate cancer aggressiveness.

View Article: PubMed Central - PubMed

Affiliation: Department of Radiology, Centre of Oncology, Maria Sklodowska-Curie Memorial Institute of Oncology, Cracow, Poland.

ABSTRACT

Background: The aim of this study was to investigate the utility of diffusion weighted imaging (DWI) using Apparent Diffusion Coefficient (ADC) values in discriminating between patients with tumors and normal prostate tissue before the initial systematic core biopsy. The relationship between histological grade of prostate cancer and ADC values in the peripheral zone was also investigated.

Material/methods: Our study included 62 patients who underwent magnetic resonance imaging (MRI) of the pelvis. The examinations were performed in T1-, T2-weighted, DWI and T1 after dynamic contrast administration sequences. In all patients there were abnormal foci within the peripheral zone determined in DWI/ADC. ADC values were compared with the Gleason score (GS) after core needle biopsy (CNB) in patients with low, medium and high stage tumors.

Results: Within the examined group of patients, ADC was statistically higher for normal tissue than for cancerous tissue (p=0.00). Mean ADC values for patients with low, intermediate and high GS were 0.85±0.03, 0.72±0.03, and 0.61±0.04, respectively.

Conclusions: DWI/ADC is useful in differentiating high-risk patients from those at low and intermediate risk, since there is a significant correlation between ADC values determined in patients included in three different groups according to their Gleason score. This information may be helpful in the assessment of prostate cancer aggressiveness.

No MeSH data available.


Related in: MedlinePlus