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Effects of spray-drying on w/o/w multiple emulsions prepared from a stearic acid matrix.

Mlalila N, Swai H, Kalombo L, Hilonga A - Nanotechnol Sci Appl (2014)

Bottom Line: The goal of this study was to explore the effects of spray-drying on w/o/w double emulsions of methyltestosterone (MT) loaded in a stearic acid matrix.Scanning electron microscopy indicated that the MT-loaded nanoparticles were spherical in shape, had a smooth surface, and were in an amorphous state, which was confirmed by differential scanning calorimetry.These MT-loaded nanoparticles are a promising candidate carrier for the delivery of MT; however, further studies are needed in order to establish the stability of the system and the cargo release profile under normal conditions of use.

View Article: PubMed Central - PubMed

Affiliation: School of Life Sciences and Bioengineering, Nelson Mandela African Institution of Science and Technology, Arusha, Tanzania.

ABSTRACT
The goal of this study was to explore the effects of spray-drying on w/o/w double emulsions of methyltestosterone (MT) loaded in a stearic acid matrix. MT-loaded nanoparticles were formulated by a water-in-oil-in-water emulsion technique using 50, 75, and 100 mg of stearic acid, 2% and 3% w/v polyvinyl alcohol, 5% w/v lactose, and 0.2% w/v chitosan. The emulsions were immediately spray-dried based on an optimized model of inlet temperature and pump rate, and characterized for optimized responses with regard to particle size, polydispersity index, and zeta potential, for both emulsion and powder samples. Dynamic light scattering analysis shown that the nanoparticles increased in size with increasing concentrations of polyvinyl alcohol and stearic acid. Scanning electron microscopy indicated that the MT-loaded nanoparticles were spherical in shape, had a smooth surface, and were in an amorphous state, which was confirmed by differential scanning calorimetry. These MT-loaded nanoparticles are a promising candidate carrier for the delivery of MT; however, further studies are needed in order to establish the stability of the system and the cargo release profile under normal conditions of use.

No MeSH data available.


Scanning electron micrograph of spray-dried, methyltestosterone-loaded nanoparticles.
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f2-nsa-7-105: Scanning electron micrograph of spray-dried, methyltestosterone-loaded nanoparticles.

Mentions: Particle morphology can be described in terms of PS, shape, internal structure, and surface properties. With few exceptions, spray-dried particles are spherical, and their size can be described by their geometric diameter, which influences the forces on particles during fluid flows and the packing of particles when they form a powder.39 The particle and surface morphology of the formulations were imaged, and the SEM images are shown in Figure 2. The spray-dried powders were observed to comprise smooth-surfaced, spherical particles with some having a “doughnut” or concave shape and a maximum diameter of 1 μm. These results are in agreement with the dynamic light scattering results obtained after 1 month under storage conditions, although the instability phenomena were not well displayed in the SEM analysis. The smoothness of the MT-loaded nanoparticle surfaces implies that no or limited aggregation occurred after 2 months of storage.


Effects of spray-drying on w/o/w multiple emulsions prepared from a stearic acid matrix.

Mlalila N, Swai H, Kalombo L, Hilonga A - Nanotechnol Sci Appl (2014)

Scanning electron micrograph of spray-dried, methyltestosterone-loaded nanoparticles.
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4257357&req=5

f2-nsa-7-105: Scanning electron micrograph of spray-dried, methyltestosterone-loaded nanoparticles.
Mentions: Particle morphology can be described in terms of PS, shape, internal structure, and surface properties. With few exceptions, spray-dried particles are spherical, and their size can be described by their geometric diameter, which influences the forces on particles during fluid flows and the packing of particles when they form a powder.39 The particle and surface morphology of the formulations were imaged, and the SEM images are shown in Figure 2. The spray-dried powders were observed to comprise smooth-surfaced, spherical particles with some having a “doughnut” or concave shape and a maximum diameter of 1 μm. These results are in agreement with the dynamic light scattering results obtained after 1 month under storage conditions, although the instability phenomena were not well displayed in the SEM analysis. The smoothness of the MT-loaded nanoparticle surfaces implies that no or limited aggregation occurred after 2 months of storage.

Bottom Line: The goal of this study was to explore the effects of spray-drying on w/o/w double emulsions of methyltestosterone (MT) loaded in a stearic acid matrix.Scanning electron microscopy indicated that the MT-loaded nanoparticles were spherical in shape, had a smooth surface, and were in an amorphous state, which was confirmed by differential scanning calorimetry.These MT-loaded nanoparticles are a promising candidate carrier for the delivery of MT; however, further studies are needed in order to establish the stability of the system and the cargo release profile under normal conditions of use.

View Article: PubMed Central - PubMed

Affiliation: School of Life Sciences and Bioengineering, Nelson Mandela African Institution of Science and Technology, Arusha, Tanzania.

ABSTRACT
The goal of this study was to explore the effects of spray-drying on w/o/w double emulsions of methyltestosterone (MT) loaded in a stearic acid matrix. MT-loaded nanoparticles were formulated by a water-in-oil-in-water emulsion technique using 50, 75, and 100 mg of stearic acid, 2% and 3% w/v polyvinyl alcohol, 5% w/v lactose, and 0.2% w/v chitosan. The emulsions were immediately spray-dried based on an optimized model of inlet temperature and pump rate, and characterized for optimized responses with regard to particle size, polydispersity index, and zeta potential, for both emulsion and powder samples. Dynamic light scattering analysis shown that the nanoparticles increased in size with increasing concentrations of polyvinyl alcohol and stearic acid. Scanning electron microscopy indicated that the MT-loaded nanoparticles were spherical in shape, had a smooth surface, and were in an amorphous state, which was confirmed by differential scanning calorimetry. These MT-loaded nanoparticles are a promising candidate carrier for the delivery of MT; however, further studies are needed in order to establish the stability of the system and the cargo release profile under normal conditions of use.

No MeSH data available.