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Effects of spray-drying on w/o/w multiple emulsions prepared from a stearic acid matrix.

Mlalila N, Swai H, Kalombo L, Hilonga A - Nanotechnol Sci Appl (2014)

Bottom Line: The goal of this study was to explore the effects of spray-drying on w/o/w double emulsions of methyltestosterone (MT) loaded in a stearic acid matrix.Scanning electron microscopy indicated that the MT-loaded nanoparticles were spherical in shape, had a smooth surface, and were in an amorphous state, which was confirmed by differential scanning calorimetry.These MT-loaded nanoparticles are a promising candidate carrier for the delivery of MT; however, further studies are needed in order to establish the stability of the system and the cargo release profile under normal conditions of use.

View Article: PubMed Central - PubMed

Affiliation: School of Life Sciences and Bioengineering, Nelson Mandela African Institution of Science and Technology, Arusha, Tanzania.

ABSTRACT
The goal of this study was to explore the effects of spray-drying on w/o/w double emulsions of methyltestosterone (MT) loaded in a stearic acid matrix. MT-loaded nanoparticles were formulated by a water-in-oil-in-water emulsion technique using 50, 75, and 100 mg of stearic acid, 2% and 3% w/v polyvinyl alcohol, 5% w/v lactose, and 0.2% w/v chitosan. The emulsions were immediately spray-dried based on an optimized model of inlet temperature and pump rate, and characterized for optimized responses with regard to particle size, polydispersity index, and zeta potential, for both emulsion and powder samples. Dynamic light scattering analysis shown that the nanoparticles increased in size with increasing concentrations of polyvinyl alcohol and stearic acid. Scanning electron microscopy indicated that the MT-loaded nanoparticles were spherical in shape, had a smooth surface, and were in an amorphous state, which was confirmed by differential scanning calorimetry. These MT-loaded nanoparticles are a promising candidate carrier for the delivery of MT; however, further studies are needed in order to establish the stability of the system and the cargo release profile under normal conditions of use.

No MeSH data available.


Melting points and crystallization of MT, physically mixed MT and SA nanoparticles.Abbreviations: MT, methyltestosterone; SA, stearic acid.
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f1-nsa-7-105: Melting points and crystallization of MT, physically mixed MT and SA nanoparticles.Abbreviations: MT, methyltestosterone; SA, stearic acid.

Mentions: Figure 1 shows the melting point and crystallization behavior of the bulk MT compound, physical mixtures of MT and SA, and SA-loaded and MT-loaded nanoparticles. At baseline, the heat flux of the reaction or transition or both is equal to zero. The upper section of Figure 1 shows respective exothermic (crystallization/cooling) isotherms, while the lower part corresponds to the endothermic (heating/melting point) enthalpy of the sample. The melting point and crystallization spectra for MT were 165°C and 138°C, respectively. SA had a stable melting point at 69°C (β-polymorphic form) and an insignificant metastable spectra (α-polymorphic form) at 174°C, with a crystallization point at 68°C.


Effects of spray-drying on w/o/w multiple emulsions prepared from a stearic acid matrix.

Mlalila N, Swai H, Kalombo L, Hilonga A - Nanotechnol Sci Appl (2014)

Melting points and crystallization of MT, physically mixed MT and SA nanoparticles.Abbreviations: MT, methyltestosterone; SA, stearic acid.
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4257357&req=5

f1-nsa-7-105: Melting points and crystallization of MT, physically mixed MT and SA nanoparticles.Abbreviations: MT, methyltestosterone; SA, stearic acid.
Mentions: Figure 1 shows the melting point and crystallization behavior of the bulk MT compound, physical mixtures of MT and SA, and SA-loaded and MT-loaded nanoparticles. At baseline, the heat flux of the reaction or transition or both is equal to zero. The upper section of Figure 1 shows respective exothermic (crystallization/cooling) isotherms, while the lower part corresponds to the endothermic (heating/melting point) enthalpy of the sample. The melting point and crystallization spectra for MT were 165°C and 138°C, respectively. SA had a stable melting point at 69°C (β-polymorphic form) and an insignificant metastable spectra (α-polymorphic form) at 174°C, with a crystallization point at 68°C.

Bottom Line: The goal of this study was to explore the effects of spray-drying on w/o/w double emulsions of methyltestosterone (MT) loaded in a stearic acid matrix.Scanning electron microscopy indicated that the MT-loaded nanoparticles were spherical in shape, had a smooth surface, and were in an amorphous state, which was confirmed by differential scanning calorimetry.These MT-loaded nanoparticles are a promising candidate carrier for the delivery of MT; however, further studies are needed in order to establish the stability of the system and the cargo release profile under normal conditions of use.

View Article: PubMed Central - PubMed

Affiliation: School of Life Sciences and Bioengineering, Nelson Mandela African Institution of Science and Technology, Arusha, Tanzania.

ABSTRACT
The goal of this study was to explore the effects of spray-drying on w/o/w double emulsions of methyltestosterone (MT) loaded in a stearic acid matrix. MT-loaded nanoparticles were formulated by a water-in-oil-in-water emulsion technique using 50, 75, and 100 mg of stearic acid, 2% and 3% w/v polyvinyl alcohol, 5% w/v lactose, and 0.2% w/v chitosan. The emulsions were immediately spray-dried based on an optimized model of inlet temperature and pump rate, and characterized for optimized responses with regard to particle size, polydispersity index, and zeta potential, for both emulsion and powder samples. Dynamic light scattering analysis shown that the nanoparticles increased in size with increasing concentrations of polyvinyl alcohol and stearic acid. Scanning electron microscopy indicated that the MT-loaded nanoparticles were spherical in shape, had a smooth surface, and were in an amorphous state, which was confirmed by differential scanning calorimetry. These MT-loaded nanoparticles are a promising candidate carrier for the delivery of MT; however, further studies are needed in order to establish the stability of the system and the cargo release profile under normal conditions of use.

No MeSH data available.