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Kaempferia parviflora extract increases energy consumption through activation of BAT in mice.

Yoshino S, Kim M, Awa R, Kuwahara H, Kano Y, Kawada T - Food Sci Nutr (2014)

Bottom Line: For both 0.5% KPE and 1.0% KPE, 7 weeks' feeding of KPE contained in a high-fat diet (HFD) significantly decreased body weight gain, intraabdominal fat accumulation, and plasma triglyceride and leptin levels.We also found that 1.0% KPE feeding significantly increased the uncoupling protein 1 (UCP1) expression in brown adipose tissue (BAT).These results demonstrate that KPE promotes energy metabolism by activation of BAT, at both doses and up-regulation of UCP1 protein at a high dose.

View Article: PubMed Central - PubMed

Affiliation: Research Center, Maruzen Pharmaceuticals Co., Ltd. Fukuyama, Hiroshima, 729-3102, Japan.

ABSTRACT
Kaempferia parviflora (KP) is a member of the ginger family and is known in Thailand as Thai ginseng, Krachai Dam or Black Ginger. TheK. parviflora extract (KPE) was previously reported to have a number of physiological effects; however, the antiobesity effects of KPE and its mechanisms remain to be elucidated. In this study, we conducted KPE feeding experiments (low dose: 0.5% KPE, high dose: 1.0% KPE) in mice to examine the antiobesity effects. For both 0.5% KPE and 1.0% KPE, 7 weeks' feeding of KPE contained in a high-fat diet (HFD) significantly decreased body weight gain, intraabdominal fat accumulation, and plasma triglyceride and leptin levels. Concurrently, KPE administration increased oxygen consumption in mice fed on a HFD. We also found that 1.0% KPE feeding significantly increased the uncoupling protein 1 (UCP1) expression in brown adipose tissue (BAT). Moreover, KPE administration increased urinary noradrenaline secretion levels. These results demonstrate that KPE promotes energy metabolism by activation of BAT, at both doses and up-regulation of UCP1 protein at a high dose. Although numerous challenges remain, the present study demonstrated that KPE suppresses HFD-induced obesity through increased energy metabolism.

No MeSH data available.


Related in: MedlinePlus

KPE suppresses body weight gain and intraabdominal fat in C57BL/6J mice. Temporal changes in body weight (A) and amount of intraabdominal fat (B) of C57BL/6J mice with and without KPE (0.5% and 1.0%) treatment for 7 weeks under HFD feeding. These procedures of animal experiments were approved by the Animal Care and Use Committee at Maruzen Pharmaceuticals Co., Ltd. (FD-A0012). Each bar represents the mean ± SE (n = 8). *P < 0.05 compared with the untreated control group. KPE,K. parviflora extract; HFD, high-fat diet.
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fig01: KPE suppresses body weight gain and intraabdominal fat in C57BL/6J mice. Temporal changes in body weight (A) and amount of intraabdominal fat (B) of C57BL/6J mice with and without KPE (0.5% and 1.0%) treatment for 7 weeks under HFD feeding. These procedures of animal experiments were approved by the Animal Care and Use Committee at Maruzen Pharmaceuticals Co., Ltd. (FD-A0012). Each bar represents the mean ± SE (n = 8). *P < 0.05 compared with the untreated control group. KPE,K. parviflora extract; HFD, high-fat diet.

Mentions: C57BL6J male mice were fed a high-fat diet (HFD; 60 kcal % fat) containing KPE (0.5 or 1.0%) for 7 weeks. In this study, both 0.5% KPE and 1.0% KPE administration significantly suppressed body weight gain and intraabdominal fat (Fig.1A and B) and decreased serum triglyceride and leptin levels (Table S1). Leptin levels are known to correlate with weight and amount of visceral fat in mice and humans (Shimizu et al. 1997; Ahren 1999); the results from the present study are consistent with these previous reports (Fig.1 and Table S1). In these experiments, there were no differences in total calories consumed during the study period (Fig. S1), suggesting that the reason for the loss of weight and intraabdominal fat was an increase in energy consumption. To explore this possibility, we examined changes in oxygen consumption using the previous method (Goto et al. 2012) after oral administration of KPE (low dose; 0.035 mg/g, high dose; 0.105 mg/g) (Fig.2A). Oxygen consumption after administration was significantly higher in mice treated with KPE. This result indicates that KPE increases oxygen consumption, thus this is one mechanism contributing to its antiobesity effects.


Kaempferia parviflora extract increases energy consumption through activation of BAT in mice.

Yoshino S, Kim M, Awa R, Kuwahara H, Kano Y, Kawada T - Food Sci Nutr (2014)

KPE suppresses body weight gain and intraabdominal fat in C57BL/6J mice. Temporal changes in body weight (A) and amount of intraabdominal fat (B) of C57BL/6J mice with and without KPE (0.5% and 1.0%) treatment for 7 weeks under HFD feeding. These procedures of animal experiments were approved by the Animal Care and Use Committee at Maruzen Pharmaceuticals Co., Ltd. (FD-A0012). Each bar represents the mean ± SE (n = 8). *P < 0.05 compared with the untreated control group. KPE,K. parviflora extract; HFD, high-fat diet.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4256566&req=5

fig01: KPE suppresses body weight gain and intraabdominal fat in C57BL/6J mice. Temporal changes in body weight (A) and amount of intraabdominal fat (B) of C57BL/6J mice with and without KPE (0.5% and 1.0%) treatment for 7 weeks under HFD feeding. These procedures of animal experiments were approved by the Animal Care and Use Committee at Maruzen Pharmaceuticals Co., Ltd. (FD-A0012). Each bar represents the mean ± SE (n = 8). *P < 0.05 compared with the untreated control group. KPE,K. parviflora extract; HFD, high-fat diet.
Mentions: C57BL6J male mice were fed a high-fat diet (HFD; 60 kcal % fat) containing KPE (0.5 or 1.0%) for 7 weeks. In this study, both 0.5% KPE and 1.0% KPE administration significantly suppressed body weight gain and intraabdominal fat (Fig.1A and B) and decreased serum triglyceride and leptin levels (Table S1). Leptin levels are known to correlate with weight and amount of visceral fat in mice and humans (Shimizu et al. 1997; Ahren 1999); the results from the present study are consistent with these previous reports (Fig.1 and Table S1). In these experiments, there were no differences in total calories consumed during the study period (Fig. S1), suggesting that the reason for the loss of weight and intraabdominal fat was an increase in energy consumption. To explore this possibility, we examined changes in oxygen consumption using the previous method (Goto et al. 2012) after oral administration of KPE (low dose; 0.035 mg/g, high dose; 0.105 mg/g) (Fig.2A). Oxygen consumption after administration was significantly higher in mice treated with KPE. This result indicates that KPE increases oxygen consumption, thus this is one mechanism contributing to its antiobesity effects.

Bottom Line: For both 0.5% KPE and 1.0% KPE, 7 weeks' feeding of KPE contained in a high-fat diet (HFD) significantly decreased body weight gain, intraabdominal fat accumulation, and plasma triglyceride and leptin levels.We also found that 1.0% KPE feeding significantly increased the uncoupling protein 1 (UCP1) expression in brown adipose tissue (BAT).These results demonstrate that KPE promotes energy metabolism by activation of BAT, at both doses and up-regulation of UCP1 protein at a high dose.

View Article: PubMed Central - PubMed

Affiliation: Research Center, Maruzen Pharmaceuticals Co., Ltd. Fukuyama, Hiroshima, 729-3102, Japan.

ABSTRACT
Kaempferia parviflora (KP) is a member of the ginger family and is known in Thailand as Thai ginseng, Krachai Dam or Black Ginger. TheK. parviflora extract (KPE) was previously reported to have a number of physiological effects; however, the antiobesity effects of KPE and its mechanisms remain to be elucidated. In this study, we conducted KPE feeding experiments (low dose: 0.5% KPE, high dose: 1.0% KPE) in mice to examine the antiobesity effects. For both 0.5% KPE and 1.0% KPE, 7 weeks' feeding of KPE contained in a high-fat diet (HFD) significantly decreased body weight gain, intraabdominal fat accumulation, and plasma triglyceride and leptin levels. Concurrently, KPE administration increased oxygen consumption in mice fed on a HFD. We also found that 1.0% KPE feeding significantly increased the uncoupling protein 1 (UCP1) expression in brown adipose tissue (BAT). Moreover, KPE administration increased urinary noradrenaline secretion levels. These results demonstrate that KPE promotes energy metabolism by activation of BAT, at both doses and up-regulation of UCP1 protein at a high dose. Although numerous challenges remain, the present study demonstrated that KPE suppresses HFD-induced obesity through increased energy metabolism.

No MeSH data available.


Related in: MedlinePlus