Uptake and intracytoplasmic storage of pigmented particles by human CD34+ stromal cells/telocytes: endocytic property of telocytes.
Bottom Line: Our results demonstrate that CD34+ TCs have endocytic properties (phagocytic-like TCs: phTCs), with the capacity to uptake and store India ink particles. phTCs conserve the characteristics of TCs (long, thin, bipolar or multipolar, moniliform cytoplasmic processes/telopodes, with linear distribution of the pigment) and maintain their typical distribution.Our ultrastructural observation of melanin-storing stromal cells with characteristics of TCs (telopodes with dichotomous branching pattern) favours this possibility.In conclusion, intestinal TCs have a phagocytic-like property, a function that may be generalized to TCs in other locations.
Affiliation: Department of Anatomy, Pathology, Histology and Radiology, Faculty of Medicine, University of La Laguna, Tenerife, Spain.Show MeSH
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Mentions: In compound melanocytic nevi, pigmented intracytoplasmic particles were observed in CD34+ stromal cells arranged near nests of naevus cells (Fig. 6A) and skin annexes (Fig. 6C). In tissue sections stained with haematoxylin and eosin, stromal cells with intracellular pigment were also observed near naevus cells (Fig. 6B). Under electron microscopy, the particles were endocytozed melanosomes and the cells showed ultrastructural characteristics of TCs (long, thin telopodes with podomeres and podoms, dichotomous branching pattern and absence of basal membrane; Fig. 6D and E).
Affiliation: Department of Anatomy, Pathology, Histology and Radiology, Faculty of Medicine, University of La Laguna, Tenerife, Spain.