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Uptake and intracytoplasmic storage of pigmented particles by human CD34+ stromal cells/telocytes: endocytic property of telocytes.

Díaz-Flores L, Gutiérrez R, García MP, Sáez FJ, Aparicio F, Díaz-Flores L, Madrid JF - J. Cell. Mol. Med. (2014)

Bottom Line: Our results demonstrate that CD34+ TCs have endocytic properties (phagocytic-like TCs: phTCs), with the capacity to uptake and store India ink particles. phTCs conserve the characteristics of TCs (long, thin, bipolar or multipolar, moniliform cytoplasmic processes/telopodes, with linear distribution of the pigment) and maintain their typical distribution.Our ultrastructural observation of melanin-storing stromal cells with characteristics of TCs (telopodes with dichotomous branching pattern) favours this possibility.In conclusion, intestinal TCs have a phagocytic-like property, a function that may be generalized to TCs in other locations.

View Article: PubMed Central - PubMed

Affiliation: Department of Anatomy, Pathology, Histology and Radiology, Faculty of Medicine, University of La Laguna, Tenerife, Spain.

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Stromal cells with intracytoplasmic pigmented particles in periodontal tissues with amalgam pigmentation. (A and C) CD34+ stromal cells with endocytozed particles (arrows). Note the arrangement of CD34+ stromal cells around different-sized vessels. (B) Stromal cells with abundant pigment around the media layer of a vessel in an HE-stained section. Note similar arrangement to CD34+ stromal cells in A. (D) A bipolar CD34+ stromal cell in the dermal interstitial compartment. Vl, Vessel lumen; ml, Media layer.
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fig05: Stromal cells with intracytoplasmic pigmented particles in periodontal tissues with amalgam pigmentation. (A and C) CD34+ stromal cells with endocytozed particles (arrows). Note the arrangement of CD34+ stromal cells around different-sized vessels. (B) Stromal cells with abundant pigment around the media layer of a vessel in an HE-stained section. Note similar arrangement to CD34+ stromal cells in A. (D) A bipolar CD34+ stromal cell in the dermal interstitial compartment. Vl, Vessel lumen; ml, Media layer.

Mentions: In amalgam pigmentation of the gingival mucosa (localized argyria), pigmented particles were stored in CD34+ cells with long, thin processes, arranged in a perivascular (Fig. 5A and C) and stromal distribution (Fig. 5D). A similar perivascular arrangement of the cells with pigment was observed in haematoxylin-stained sections (Fig. 5B). Foreign-body reaction and repair findings were associated in one case.


Uptake and intracytoplasmic storage of pigmented particles by human CD34+ stromal cells/telocytes: endocytic property of telocytes.

Díaz-Flores L, Gutiérrez R, García MP, Sáez FJ, Aparicio F, Díaz-Flores L, Madrid JF - J. Cell. Mol. Med. (2014)

Stromal cells with intracytoplasmic pigmented particles in periodontal tissues with amalgam pigmentation. (A and C) CD34+ stromal cells with endocytozed particles (arrows). Note the arrangement of CD34+ stromal cells around different-sized vessels. (B) Stromal cells with abundant pigment around the media layer of a vessel in an HE-stained section. Note similar arrangement to CD34+ stromal cells in A. (D) A bipolar CD34+ stromal cell in the dermal interstitial compartment. Vl, Vessel lumen; ml, Media layer.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4256559&req=5

fig05: Stromal cells with intracytoplasmic pigmented particles in periodontal tissues with amalgam pigmentation. (A and C) CD34+ stromal cells with endocytozed particles (arrows). Note the arrangement of CD34+ stromal cells around different-sized vessels. (B) Stromal cells with abundant pigment around the media layer of a vessel in an HE-stained section. Note similar arrangement to CD34+ stromal cells in A. (D) A bipolar CD34+ stromal cell in the dermal interstitial compartment. Vl, Vessel lumen; ml, Media layer.
Mentions: In amalgam pigmentation of the gingival mucosa (localized argyria), pigmented particles were stored in CD34+ cells with long, thin processes, arranged in a perivascular (Fig. 5A and C) and stromal distribution (Fig. 5D). A similar perivascular arrangement of the cells with pigment was observed in haematoxylin-stained sections (Fig. 5B). Foreign-body reaction and repair findings were associated in one case.

Bottom Line: Our results demonstrate that CD34+ TCs have endocytic properties (phagocytic-like TCs: phTCs), with the capacity to uptake and store India ink particles. phTCs conserve the characteristics of TCs (long, thin, bipolar or multipolar, moniliform cytoplasmic processes/telopodes, with linear distribution of the pigment) and maintain their typical distribution.Our ultrastructural observation of melanin-storing stromal cells with characteristics of TCs (telopodes with dichotomous branching pattern) favours this possibility.In conclusion, intestinal TCs have a phagocytic-like property, a function that may be generalized to TCs in other locations.

View Article: PubMed Central - PubMed

Affiliation: Department of Anatomy, Pathology, Histology and Radiology, Faculty of Medicine, University of La Laguna, Tenerife, Spain.

Show MeSH
Related in: MedlinePlus