Uptake and intracytoplasmic storage of pigmented particles by human CD34+ stromal cells/telocytes: endocytic property of telocytes.
Bottom Line: Our results demonstrate that CD34+ TCs have endocytic properties (phagocytic-like TCs: phTCs), with the capacity to uptake and store India ink particles. phTCs conserve the characteristics of TCs (long, thin, bipolar or multipolar, moniliform cytoplasmic processes/telopodes, with linear distribution of the pigment) and maintain their typical distribution.Our ultrastructural observation of melanin-storing stromal cells with characteristics of TCs (telopodes with dichotomous branching pattern) favours this possibility.In conclusion, intestinal TCs have a phagocytic-like property, a function that may be generalized to TCs in other locations.
Affiliation: Department of Anatomy, Pathology, Histology and Radiology, Faculty of Medicine, University of La Laguna, Tenerife, Spain.Show MeSH
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Mentions: In pigmented purpuric dermatoses with hemosiderin deposition, stromal cells with intracytoplasmic iron deposition (Perl Prussian blue stained) were present in the dermis (Fig. 4A and B). CD34+ cells with appearance of TCs and with pigmented intracytoplasmic particles were observed (Fig. 4C–E). These cells showed an arrangement around vessels and skin annexes, such as sweat glands (Fig. 4E).
Affiliation: Department of Anatomy, Pathology, Histology and Radiology, Faculty of Medicine, University of La Laguna, Tenerife, Spain.