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Uptake and intracytoplasmic storage of pigmented particles by human CD34+ stromal cells/telocytes: endocytic property of telocytes.

Díaz-Flores L, Gutiérrez R, García MP, Sáez FJ, Aparicio F, Díaz-Flores L, Madrid JF - J. Cell. Mol. Med. (2014)

Bottom Line: Our results demonstrate that CD34+ TCs have endocytic properties (phagocytic-like TCs: phTCs), with the capacity to uptake and store India ink particles. phTCs conserve the characteristics of TCs (long, thin, bipolar or multipolar, moniliform cytoplasmic processes/telopodes, with linear distribution of the pigment) and maintain their typical distribution.Our ultrastructural observation of melanin-storing stromal cells with characteristics of TCs (telopodes with dichotomous branching pattern) favours this possibility.In conclusion, intestinal TCs have a phagocytic-like property, a function that may be generalized to TCs in other locations.

View Article: PubMed Central - PubMed

Affiliation: Department of Anatomy, Pathology, Histology and Radiology, Faculty of Medicine, University of La Laguna, Tenerife, Spain.

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Stromal cells with intracytoplasmic pigmented particles in purpuric dermatoses (hemosiderin deposition). (A and B) Stromal cells, around a vessel (A) and in the interstitium (B) of the reticular dermis, obtained from sections with Perl Prussian blue stain. (C–E) CD34+ stromal cells with endocytozed particles of hemosiderin (arrows) in the reticular dermis (C and D) and around a sweat gland (D, sg).
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fig04: Stromal cells with intracytoplasmic pigmented particles in purpuric dermatoses (hemosiderin deposition). (A and B) Stromal cells, around a vessel (A) and in the interstitium (B) of the reticular dermis, obtained from sections with Perl Prussian blue stain. (C–E) CD34+ stromal cells with endocytozed particles of hemosiderin (arrows) in the reticular dermis (C and D) and around a sweat gland (D, sg).

Mentions: In pigmented purpuric dermatoses with hemosiderin deposition, stromal cells with intracytoplasmic iron deposition (Perl Prussian blue stained) were present in the dermis (Fig. 4A and B). CD34+ cells with appearance of TCs and with pigmented intracytoplasmic particles were observed (Fig. 4C–E). These cells showed an arrangement around vessels and skin annexes, such as sweat glands (Fig. 4E).


Uptake and intracytoplasmic storage of pigmented particles by human CD34+ stromal cells/telocytes: endocytic property of telocytes.

Díaz-Flores L, Gutiérrez R, García MP, Sáez FJ, Aparicio F, Díaz-Flores L, Madrid JF - J. Cell. Mol. Med. (2014)

Stromal cells with intracytoplasmic pigmented particles in purpuric dermatoses (hemosiderin deposition). (A and B) Stromal cells, around a vessel (A) and in the interstitium (B) of the reticular dermis, obtained from sections with Perl Prussian blue stain. (C–E) CD34+ stromal cells with endocytozed particles of hemosiderin (arrows) in the reticular dermis (C and D) and around a sweat gland (D, sg).
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4256559&req=5

fig04: Stromal cells with intracytoplasmic pigmented particles in purpuric dermatoses (hemosiderin deposition). (A and B) Stromal cells, around a vessel (A) and in the interstitium (B) of the reticular dermis, obtained from sections with Perl Prussian blue stain. (C–E) CD34+ stromal cells with endocytozed particles of hemosiderin (arrows) in the reticular dermis (C and D) and around a sweat gland (D, sg).
Mentions: In pigmented purpuric dermatoses with hemosiderin deposition, stromal cells with intracytoplasmic iron deposition (Perl Prussian blue stained) were present in the dermis (Fig. 4A and B). CD34+ cells with appearance of TCs and with pigmented intracytoplasmic particles were observed (Fig. 4C–E). These cells showed an arrangement around vessels and skin annexes, such as sweat glands (Fig. 4E).

Bottom Line: Our results demonstrate that CD34+ TCs have endocytic properties (phagocytic-like TCs: phTCs), with the capacity to uptake and store India ink particles. phTCs conserve the characteristics of TCs (long, thin, bipolar or multipolar, moniliform cytoplasmic processes/telopodes, with linear distribution of the pigment) and maintain their typical distribution.Our ultrastructural observation of melanin-storing stromal cells with characteristics of TCs (telopodes with dichotomous branching pattern) favours this possibility.In conclusion, intestinal TCs have a phagocytic-like property, a function that may be generalized to TCs in other locations.

View Article: PubMed Central - PubMed

Affiliation: Department of Anatomy, Pathology, Histology and Radiology, Faculty of Medicine, University of La Laguna, Tenerife, Spain.

Show MeSH
Related in: MedlinePlus