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Hypertension and risk of cataract: a meta-analysis.

Yu X, Lyu D, Dong X, He J, Yao K - PLoS ONE (2014)

Bottom Line: This association was proved to be true among both Mongolians and Caucasians, and the significance was not altered by the adjustment of main components of MS.No association of hypertension with risk of nuclear cataract was found.Further efforts should be made to explore the potential biological mechanisms.

View Article: PubMed Central - PubMed

Affiliation: Eye Center, Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China.

ABSTRACT

Background: Cataract is the major cause of blindness across the world. Many epidemiologic studies indicated that hypertension might play an important role in the development of cataract, while others not. We therefore conducted this meta-analysis to determine the relationship between risk of cataract and hypertension.

Methods: Retrieved studies on the association of hypertension with cataract risk were collected from PubMed, Web of Science and the Cochrane Library during June 2014 and were included into the final analysis according to the definite inclusion criteria. Odds ratio (OR) or risk ratio (RR) were pooled with 95% confidence interval (CI) to evaluate the relationship between hypertension and cataract risk. Subgroup analyses were carried out on the basis of cataract type, race and whether studies were adjusted for main components of metabolic syndrome (MS).

Results: The final meta-analysis included 25 studies (9 cohort, 5 case-control and 11 cross-sectional) from 23 articles. The pooled results showed that cataract risk in populations with hypertension significantly increased among cohort studies (RR 1.08; 95% CI: 1.05-1.12) and case-control or cross-sectional studies (OR 1.28; 95% CI: 1.12-1.45). This association was proved to be true among both Mongolians and Caucasians, and the significance was not altered by the adjustment of main components of MS. Subgroup analysis on cataract types indicated that an increased incidence of posterior subcapsular cataract (PSC) resulted among cohort studies (RR 1.22; 95% CI: 1.03-1.46) and cross-sectional/case-control studies (OR 1.23; 95% CI: 1.09-1.39). No association of hypertension with risk of nuclear cataract was found.

Conclusions: The present meta-analysis suggests that hypertension increases the risk of cataract, especially PSC. Further efforts should be made to explore the potential biological mechanisms.

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The association of hypertension with risk of cataract subtypes in cohort studies.
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pone-0114012-g006: The association of hypertension with risk of cataract subtypes in cohort studies.

Mentions: Figure 6 showed that 6 of 9 cohort studies afforded RR values with corresponding 95% CI for subgroup analysis. The outcome of subgroup analysis suggested that hypertension was significantly associated with PSC risk (RR 1.22, 95% CI: 1.03–1.46; I2 = 0%, P heterogeneity = 0.683). However, no evidence of a significant relationship between hypertension and cortical or nuclear cataract risk was found in the 6 included studies (cortical cataract: RR 1.02, 95% CI: 0.88–1.19; I2 = 0%, P heterogeneity = 0.673; nuclear cataract: RR 1.07, 95% CI: 0.95–1.20; I2 = 0%, P heterogeneity = 0.523) (Figure 6). No significant publication bias was detected in the three subgroups by means of Egger’s and Begg’s tests (PSC: Begg’s P = 0.46, Egger’s P = 0.31; cortical cataract: Begg’s P = 0.81, Egger’s P = 0.43; nuclear cataract: Begg’s P = 0.45, Egger’s P = 0.84).


Hypertension and risk of cataract: a meta-analysis.

Yu X, Lyu D, Dong X, He J, Yao K - PLoS ONE (2014)

The association of hypertension with risk of cataract subtypes in cohort studies.
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4256215&req=5

pone-0114012-g006: The association of hypertension with risk of cataract subtypes in cohort studies.
Mentions: Figure 6 showed that 6 of 9 cohort studies afforded RR values with corresponding 95% CI for subgroup analysis. The outcome of subgroup analysis suggested that hypertension was significantly associated with PSC risk (RR 1.22, 95% CI: 1.03–1.46; I2 = 0%, P heterogeneity = 0.683). However, no evidence of a significant relationship between hypertension and cortical or nuclear cataract risk was found in the 6 included studies (cortical cataract: RR 1.02, 95% CI: 0.88–1.19; I2 = 0%, P heterogeneity = 0.673; nuclear cataract: RR 1.07, 95% CI: 0.95–1.20; I2 = 0%, P heterogeneity = 0.523) (Figure 6). No significant publication bias was detected in the three subgroups by means of Egger’s and Begg’s tests (PSC: Begg’s P = 0.46, Egger’s P = 0.31; cortical cataract: Begg’s P = 0.81, Egger’s P = 0.43; nuclear cataract: Begg’s P = 0.45, Egger’s P = 0.84).

Bottom Line: This association was proved to be true among both Mongolians and Caucasians, and the significance was not altered by the adjustment of main components of MS.No association of hypertension with risk of nuclear cataract was found.Further efforts should be made to explore the potential biological mechanisms.

View Article: PubMed Central - PubMed

Affiliation: Eye Center, Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China.

ABSTRACT

Background: Cataract is the major cause of blindness across the world. Many epidemiologic studies indicated that hypertension might play an important role in the development of cataract, while others not. We therefore conducted this meta-analysis to determine the relationship between risk of cataract and hypertension.

Methods: Retrieved studies on the association of hypertension with cataract risk were collected from PubMed, Web of Science and the Cochrane Library during June 2014 and were included into the final analysis according to the definite inclusion criteria. Odds ratio (OR) or risk ratio (RR) were pooled with 95% confidence interval (CI) to evaluate the relationship between hypertension and cataract risk. Subgroup analyses were carried out on the basis of cataract type, race and whether studies were adjusted for main components of metabolic syndrome (MS).

Results: The final meta-analysis included 25 studies (9 cohort, 5 case-control and 11 cross-sectional) from 23 articles. The pooled results showed that cataract risk in populations with hypertension significantly increased among cohort studies (RR 1.08; 95% CI: 1.05-1.12) and case-control or cross-sectional studies (OR 1.28; 95% CI: 1.12-1.45). This association was proved to be true among both Mongolians and Caucasians, and the significance was not altered by the adjustment of main components of MS. Subgroup analysis on cataract types indicated that an increased incidence of posterior subcapsular cataract (PSC) resulted among cohort studies (RR 1.22; 95% CI: 1.03-1.46) and cross-sectional/case-control studies (OR 1.23; 95% CI: 1.09-1.39). No association of hypertension with risk of nuclear cataract was found.

Conclusions: The present meta-analysis suggests that hypertension increases the risk of cataract, especially PSC. Further efforts should be made to explore the potential biological mechanisms.

Show MeSH
Related in: MedlinePlus