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Hypertension and risk of cataract: a meta-analysis.

Yu X, Lyu D, Dong X, He J, Yao K - PLoS ONE (2014)

Bottom Line: This association was proved to be true among both Mongolians and Caucasians, and the significance was not altered by the adjustment of main components of MS.No association of hypertension with risk of nuclear cataract was found.Further efforts should be made to explore the potential biological mechanisms.

View Article: PubMed Central - PubMed

Affiliation: Eye Center, Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China.

ABSTRACT

Background: Cataract is the major cause of blindness across the world. Many epidemiologic studies indicated that hypertension might play an important role in the development of cataract, while others not. We therefore conducted this meta-analysis to determine the relationship between risk of cataract and hypertension.

Methods: Retrieved studies on the association of hypertension with cataract risk were collected from PubMed, Web of Science and the Cochrane Library during June 2014 and were included into the final analysis according to the definite inclusion criteria. Odds ratio (OR) or risk ratio (RR) were pooled with 95% confidence interval (CI) to evaluate the relationship between hypertension and cataract risk. Subgroup analyses were carried out on the basis of cataract type, race and whether studies were adjusted for main components of metabolic syndrome (MS).

Results: The final meta-analysis included 25 studies (9 cohort, 5 case-control and 11 cross-sectional) from 23 articles. The pooled results showed that cataract risk in populations with hypertension significantly increased among cohort studies (RR 1.08; 95% CI: 1.05-1.12) and case-control or cross-sectional studies (OR 1.28; 95% CI: 1.12-1.45). This association was proved to be true among both Mongolians and Caucasians, and the significance was not altered by the adjustment of main components of MS. Subgroup analysis on cataract types indicated that an increased incidence of posterior subcapsular cataract (PSC) resulted among cohort studies (RR 1.22; 95% CI: 1.03-1.46) and cross-sectional/case-control studies (OR 1.23; 95% CI: 1.09-1.39). No association of hypertension with risk of nuclear cataract was found.

Conclusions: The present meta-analysis suggests that hypertension increases the risk of cataract, especially PSC. Further efforts should be made to explore the potential biological mechanisms.

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The association of hypertension with cataract risk in case-control/cross-sectional studies.
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pone-0114012-g002: The association of hypertension with cataract risk in case-control/cross-sectional studies.

Mentions: The pooled results of the 14 studies showed that risk of any type of cataract was significantly higher in patients with hypertension (OR 1.28, 95% CI: 1.12–1.45; I2 = 72.9%, P heterogeneity<0.001) than in subjects with normal blood pressure (Figure 2). No significant publication bias was found among the included studies (Begg’s P = 0.23, Egger’s P = 0.34). Similar estimates were found among Mongolians (OR 1.30, 95% CI: 1.08–1.55; I2 = 77.7%, P heterogeneity<0.001; Begg’s P = 0.54, Egger’s P = 0.26). Sensitivity analysis by sequentially omitting individual studies did not alter the significance of pooled OR estimates [3], [7]–[10], [28]–[32], [34], [36]–[37], which ranged from 1.24 (95% CI: 1.09–1.41) to 1.32 (95% CI: 1.17–1.48). We conducted meta-regression analyses to explore the influences of sample size, study design, study conducted race, publication year and cataract criteria on heterogeneity, but none of them was proved to be the main source of heterogeneity (P>0.05).


Hypertension and risk of cataract: a meta-analysis.

Yu X, Lyu D, Dong X, He J, Yao K - PLoS ONE (2014)

The association of hypertension with cataract risk in case-control/cross-sectional studies.
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4256215&req=5

pone-0114012-g002: The association of hypertension with cataract risk in case-control/cross-sectional studies.
Mentions: The pooled results of the 14 studies showed that risk of any type of cataract was significantly higher in patients with hypertension (OR 1.28, 95% CI: 1.12–1.45; I2 = 72.9%, P heterogeneity<0.001) than in subjects with normal blood pressure (Figure 2). No significant publication bias was found among the included studies (Begg’s P = 0.23, Egger’s P = 0.34). Similar estimates were found among Mongolians (OR 1.30, 95% CI: 1.08–1.55; I2 = 77.7%, P heterogeneity<0.001; Begg’s P = 0.54, Egger’s P = 0.26). Sensitivity analysis by sequentially omitting individual studies did not alter the significance of pooled OR estimates [3], [7]–[10], [28]–[32], [34], [36]–[37], which ranged from 1.24 (95% CI: 1.09–1.41) to 1.32 (95% CI: 1.17–1.48). We conducted meta-regression analyses to explore the influences of sample size, study design, study conducted race, publication year and cataract criteria on heterogeneity, but none of them was proved to be the main source of heterogeneity (P>0.05).

Bottom Line: This association was proved to be true among both Mongolians and Caucasians, and the significance was not altered by the adjustment of main components of MS.No association of hypertension with risk of nuclear cataract was found.Further efforts should be made to explore the potential biological mechanisms.

View Article: PubMed Central - PubMed

Affiliation: Eye Center, Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China.

ABSTRACT

Background: Cataract is the major cause of blindness across the world. Many epidemiologic studies indicated that hypertension might play an important role in the development of cataract, while others not. We therefore conducted this meta-analysis to determine the relationship between risk of cataract and hypertension.

Methods: Retrieved studies on the association of hypertension with cataract risk were collected from PubMed, Web of Science and the Cochrane Library during June 2014 and were included into the final analysis according to the definite inclusion criteria. Odds ratio (OR) or risk ratio (RR) were pooled with 95% confidence interval (CI) to evaluate the relationship between hypertension and cataract risk. Subgroup analyses were carried out on the basis of cataract type, race and whether studies were adjusted for main components of metabolic syndrome (MS).

Results: The final meta-analysis included 25 studies (9 cohort, 5 case-control and 11 cross-sectional) from 23 articles. The pooled results showed that cataract risk in populations with hypertension significantly increased among cohort studies (RR 1.08; 95% CI: 1.05-1.12) and case-control or cross-sectional studies (OR 1.28; 95% CI: 1.12-1.45). This association was proved to be true among both Mongolians and Caucasians, and the significance was not altered by the adjustment of main components of MS. Subgroup analysis on cataract types indicated that an increased incidence of posterior subcapsular cataract (PSC) resulted among cohort studies (RR 1.22; 95% CI: 1.03-1.46) and cross-sectional/case-control studies (OR 1.23; 95% CI: 1.09-1.39). No association of hypertension with risk of nuclear cataract was found.

Conclusions: The present meta-analysis suggests that hypertension increases the risk of cataract, especially PSC. Further efforts should be made to explore the potential biological mechanisms.

Show MeSH
Related in: MedlinePlus