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Risk factors for postural tachycardia syndrome in children and adolescents.

Lin J, Han Z, Li X, Ochs T, Zhao J, Zhang X, Yang J, Liu P, Xiong Z, Gai Y, Tang C, Du J, Jin H - PLoS ONE (2014)

Bottom Line: But its risk factors have not been fully understood.Heart rate (HR) and blood pressure (BP) were monitored during upright test.Furthermore, in validation group, predictive sensitivity and specificity were 73.3% and 72.5%.

View Article: PubMed Central - PubMed

Affiliation: Department of Pediatrics, Peking University First Hospital, Beijing, China.

ABSTRACT

Background: Postural tachycardia syndrome (POTS) is prevalent in children and adolescents and has a great impact on health. But its risk factors have not been fully understood. This study aimed to explore possible risk factors for children and adolescents with POTS.

Methods and findings: 600 children and adolescents (test group) aged 7-18 (11.9 ± 3.0) years old, 259 males and 341 females, were recruited for identifying its risk factors. Another 197 subjects aged from 7 to 18 (11.3 ± 2.3) years old were enrolled in the validation group. Heart rate (HR) and blood pressure (BP) were monitored during upright test. Risk factors were analyzed and sensitivity and specificity for predicting POTS were tested via receiver operating characteristic curve. Among 600 subjects, 41 were confirmed with POTS patients (6.8%) based on clinical manifestation and upright test. The results showed a significant difference in daily water intake, the daily sleeping hours, supine HR, HR increment and maximum HR during upright test between POTS and the unaffected children (P<0.05). Likelihood of POTS would increase by 1.583 times if supine HR was increased by 10 beats/min (95%CI 1.184 to 2.116, P<0.01), by 3.877 times if a child's water intake was less than 800 ml/day (95%CI 1.937 to 7.760, P<0.001), or by 5.905 times (95%CI 2.972 to 11.733, P<0.001) if sleeping hours were less than 8 hours/day. Supine HR, daily water intake and sleeping hours showed the capability of predicting POTS in children and adolescents with an AUC of 83.9% (95% CI: 78.6%-89.1%), sensitivity of 80.5% and specificity of 75%. Furthermore, in validation group, predictive sensitivity and specificity were 73.3% and 72.5%.

Conclusion: Faster supine HR, less water intake and shorter sleeping hours were identified as risk factors for POTS.

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Related in: MedlinePlus

The receiver-operating characteristic (ROC) curve of the Logistic multivariate regression equation for predicting the likelihood of POTS.The longitudinal axis represents sensitivity to predict the probability of POTS. The transversal axis represents the false positive rate (1-specificity) of the prediction. The 45° gray line of the graph stands for reference line, representing sensitivity being equal to false positive rate (e.g., does not have the predictive value completely). The red curve is farther from the reference line and nearer the upper left corner of the graph. Area under the curve was 0.839 (95% confidence interval: 0.786 to 0.891; p<0.001).
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pone-0113625-g001: The receiver-operating characteristic (ROC) curve of the Logistic multivariate regression equation for predicting the likelihood of POTS.The longitudinal axis represents sensitivity to predict the probability of POTS. The transversal axis represents the false positive rate (1-specificity) of the prediction. The 45° gray line of the graph stands for reference line, representing sensitivity being equal to false positive rate (e.g., does not have the predictive value completely). The red curve is farther from the reference line and nearer the upper left corner of the graph. Area under the curve was 0.839 (95% confidence interval: 0.786 to 0.891; p<0.001).

Mentions: To determine whether the three aforementioned factors could be regarded as true predictors for POTS in children, we applied ROC analysis. It showed that when the Youden Index was the highest, the cutoff point was −2.65, meaning that we could confidently predict POTS in a patient if the abovementioned result was equal to or greater than −2.65. Accordingly, the area under curve (AUC) was 83.9%, the sensitivity 80.5% and the specificity 75% (Figure 1).


Risk factors for postural tachycardia syndrome in children and adolescents.

Lin J, Han Z, Li X, Ochs T, Zhao J, Zhang X, Yang J, Liu P, Xiong Z, Gai Y, Tang C, Du J, Jin H - PLoS ONE (2014)

The receiver-operating characteristic (ROC) curve of the Logistic multivariate regression equation for predicting the likelihood of POTS.The longitudinal axis represents sensitivity to predict the probability of POTS. The transversal axis represents the false positive rate (1-specificity) of the prediction. The 45° gray line of the graph stands for reference line, representing sensitivity being equal to false positive rate (e.g., does not have the predictive value completely). The red curve is farther from the reference line and nearer the upper left corner of the graph. Area under the curve was 0.839 (95% confidence interval: 0.786 to 0.891; p<0.001).
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4256207&req=5

pone-0113625-g001: The receiver-operating characteristic (ROC) curve of the Logistic multivariate regression equation for predicting the likelihood of POTS.The longitudinal axis represents sensitivity to predict the probability of POTS. The transversal axis represents the false positive rate (1-specificity) of the prediction. The 45° gray line of the graph stands for reference line, representing sensitivity being equal to false positive rate (e.g., does not have the predictive value completely). The red curve is farther from the reference line and nearer the upper left corner of the graph. Area under the curve was 0.839 (95% confidence interval: 0.786 to 0.891; p<0.001).
Mentions: To determine whether the three aforementioned factors could be regarded as true predictors for POTS in children, we applied ROC analysis. It showed that when the Youden Index was the highest, the cutoff point was −2.65, meaning that we could confidently predict POTS in a patient if the abovementioned result was equal to or greater than −2.65. Accordingly, the area under curve (AUC) was 83.9%, the sensitivity 80.5% and the specificity 75% (Figure 1).

Bottom Line: But its risk factors have not been fully understood.Heart rate (HR) and blood pressure (BP) were monitored during upright test.Furthermore, in validation group, predictive sensitivity and specificity were 73.3% and 72.5%.

View Article: PubMed Central - PubMed

Affiliation: Department of Pediatrics, Peking University First Hospital, Beijing, China.

ABSTRACT

Background: Postural tachycardia syndrome (POTS) is prevalent in children and adolescents and has a great impact on health. But its risk factors have not been fully understood. This study aimed to explore possible risk factors for children and adolescents with POTS.

Methods and findings: 600 children and adolescents (test group) aged 7-18 (11.9 ± 3.0) years old, 259 males and 341 females, were recruited for identifying its risk factors. Another 197 subjects aged from 7 to 18 (11.3 ± 2.3) years old were enrolled in the validation group. Heart rate (HR) and blood pressure (BP) were monitored during upright test. Risk factors were analyzed and sensitivity and specificity for predicting POTS were tested via receiver operating characteristic curve. Among 600 subjects, 41 were confirmed with POTS patients (6.8%) based on clinical manifestation and upright test. The results showed a significant difference in daily water intake, the daily sleeping hours, supine HR, HR increment and maximum HR during upright test between POTS and the unaffected children (P<0.05). Likelihood of POTS would increase by 1.583 times if supine HR was increased by 10 beats/min (95%CI 1.184 to 2.116, P<0.01), by 3.877 times if a child's water intake was less than 800 ml/day (95%CI 1.937 to 7.760, P<0.001), or by 5.905 times (95%CI 2.972 to 11.733, P<0.001) if sleeping hours were less than 8 hours/day. Supine HR, daily water intake and sleeping hours showed the capability of predicting POTS in children and adolescents with an AUC of 83.9% (95% CI: 78.6%-89.1%), sensitivity of 80.5% and specificity of 75%. Furthermore, in validation group, predictive sensitivity and specificity were 73.3% and 72.5%.

Conclusion: Faster supine HR, less water intake and shorter sleeping hours were identified as risk factors for POTS.

Show MeSH
Related in: MedlinePlus