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Motor fMRI and cortical grey matter volume in adults born very preterm.

Lawrence EJ, Froudist-Walsh S, Neilan R, Nam KW, Giampietro V, McGuire P, Murray RM, Nosarti C - Dev Cogn Neurosci (2014)

Bottom Line: The primary aim of this study was to investigate the functional neuroanatomy of motor planning, initiation and execution in a cohort of young adults (mean age 20 years) who were born very preterm (VPT; <33 weeks of gestation), as these individuals are at increased risk of experiencing neuromotor difficulties compared to controls.The VPT group also displayed decreased grey matter volume in the right superior frontal/premotor cortex and left middle temporal gyri.Grey matter volume in the premotor and middle temporal clusters was significantly negatively correlated with BOLD activation in the cerebellum.

View Article: PubMed Central - PubMed

Affiliation: Department of Psychosis Studies, Institute of Psychiatry, King's Health Partners, King's College London, De Crespigny Park, London SE5 8AF, UK. Electronic address: emma.lawrence@kcl.ac.uk.

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Related in: MedlinePlus

Foci of between-group activation for VPT ≥ control for move ≥ rest (hot) (p ≤ 0.05, corrected for multiple comparisons). Areas of decreased grey matter volume in the VPT group compared to controls are shown in blue (p ≤ 0.001, uncorrected for multiple comparisons). Structural and functional clusters are overlaid on the study-specific average template created from all participants’ T1-weighted scans, linearly registered to MNI space to allow for reference to MNI Z-axis labels. Image left = anatomical left. (For interpretation of the references to colour in this figure legend, the reader is referred to the web version of this article.)
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fig0015: Foci of between-group activation for VPT ≥ control for move ≥ rest (hot) (p ≤ 0.05, corrected for multiple comparisons). Areas of decreased grey matter volume in the VPT group compared to controls are shown in blue (p ≤ 0.001, uncorrected for multiple comparisons). Structural and functional clusters are overlaid on the study-specific average template created from all participants’ T1-weighted scans, linearly registered to MNI space to allow for reference to MNI Z-axis labels. Image left = anatomical left. (For interpretation of the references to colour in this figure legend, the reader is referred to the web version of this article.)

Mentions: Compared to control participants, the VPT group displayed increased brain activation in a large cluster with a peak in the right cerebellum, that extended into right lingual, parahippocampal and middle temporal gyri (Fig. 1 and Table 2).


Motor fMRI and cortical grey matter volume in adults born very preterm.

Lawrence EJ, Froudist-Walsh S, Neilan R, Nam KW, Giampietro V, McGuire P, Murray RM, Nosarti C - Dev Cogn Neurosci (2014)

Foci of between-group activation for VPT ≥ control for move ≥ rest (hot) (p ≤ 0.05, corrected for multiple comparisons). Areas of decreased grey matter volume in the VPT group compared to controls are shown in blue (p ≤ 0.001, uncorrected for multiple comparisons). Structural and functional clusters are overlaid on the study-specific average template created from all participants’ T1-weighted scans, linearly registered to MNI space to allow for reference to MNI Z-axis labels. Image left = anatomical left. (For interpretation of the references to colour in this figure legend, the reader is referred to the web version of this article.)
© Copyright Policy
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC4256062&req=5

fig0015: Foci of between-group activation for VPT ≥ control for move ≥ rest (hot) (p ≤ 0.05, corrected for multiple comparisons). Areas of decreased grey matter volume in the VPT group compared to controls are shown in blue (p ≤ 0.001, uncorrected for multiple comparisons). Structural and functional clusters are overlaid on the study-specific average template created from all participants’ T1-weighted scans, linearly registered to MNI space to allow for reference to MNI Z-axis labels. Image left = anatomical left. (For interpretation of the references to colour in this figure legend, the reader is referred to the web version of this article.)
Mentions: Compared to control participants, the VPT group displayed increased brain activation in a large cluster with a peak in the right cerebellum, that extended into right lingual, parahippocampal and middle temporal gyri (Fig. 1 and Table 2).

Bottom Line: The primary aim of this study was to investigate the functional neuroanatomy of motor planning, initiation and execution in a cohort of young adults (mean age 20 years) who were born very preterm (VPT; <33 weeks of gestation), as these individuals are at increased risk of experiencing neuromotor difficulties compared to controls.The VPT group also displayed decreased grey matter volume in the right superior frontal/premotor cortex and left middle temporal gyri.Grey matter volume in the premotor and middle temporal clusters was significantly negatively correlated with BOLD activation in the cerebellum.

View Article: PubMed Central - PubMed

Affiliation: Department of Psychosis Studies, Institute of Psychiatry, King's Health Partners, King's College London, De Crespigny Park, London SE5 8AF, UK. Electronic address: emma.lawrence@kcl.ac.uk.

Show MeSH
Related in: MedlinePlus