Limits...
Methicillin-resistant Staphylococcus aureus in HIV patients: risk factors associated with colonization and/or infection and methods for characterization of isolates - a systematic review.

Ferreira Dde C, Silva GR, Cavalcante FS, Carmo FL, Fernandes LA, Moreira S, Passos MR, Colombo AP, Santos KR - Clinics (Sao Paulo) (2014)

Bottom Line: Genotypic profiles were accessed by pulsed-field gel electrophoresis (6/9 studies) and USA300 was the most prevalent lineage (5/9 studies).Most isolates were resistant to erythromycin (3/9 studies) and susceptible to vancomycin (4/9 studies).However, the numbers of evaluated patients, the exclusion and inclusion criteria and the characterization of the S. aureus isolates were not uniform, which made it difficult to establish the characteristics associated with HIV patients who are colonized/infected by S. aureus.

View Article: PubMed Central - PubMed

Affiliation: Bolsista da Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES), CAPES Foundation, Brasilia, DF, Brazil.

ABSTRACT
Staphylococcus aureus is an important cause of infections and HIV-infected individuals are frequently susceptible to this pathogen. The aim of this study was to perform a systematic review to identify both the risk factors associated with colonization/infection by methicillin-resistant S. aureus in HIV patients and the methods used for characterization of isolates. An electronic search of articles published between January 2001 and December 2013 was first conducted. Among 116 studies categorized as being at a quality level of A, B or C, only 9 studies were considered to have high methodological quality (level A). The majority of these studies were retrospective (4/9 studies). The risk factors associated with colonization/infection by S. aureus were use of antimicrobials (4/9 studies), previous hospitalization (4/9 studies) and low CD4+ T lymphocyte counts (<200 cells/μl) (3/9 studies). Culture in mannitol salt agar (3/9 studies) and the latex agglutination test (5/9 studies) were the main methods used for bacterial phenotypic identification. Genotypic profiles were accessed by pulsed-field gel electrophoresis (6/9 studies) and USA300 was the most prevalent lineage (5/9 studies). Most isolates were resistant to erythromycin (3/9 studies) and susceptible to vancomycin (4/9 studies). Ultimately, use of antimicrobials and previous hospitalization were the main risk factors for colonization/infection by methicillin-resistant S. aureus in HIV-infected individuals. However, the numbers of evaluated patients, the exclusion and inclusion criteria and the characterization of the S. aureus isolates were not uniform, which made it difficult to establish the characteristics associated with HIV patients who are colonized/infected by S. aureus.

Show MeSH

Related in: MedlinePlus

- Outline of the steps for the selection of the studies.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
getmorefigures.php?uid=PMC4256048&req=5

f1-cln_69p770: - Outline of the steps for the selection of the studies.

Mentions: Figure 1 outlines the steps for the selection of the studies. The number of articles found in and selected from the databases is listed in Table 2. An initial electronic search of the health sciences databases using the keywords uncovered a total of 911, 29, 841, 11 and 1,115 articles from PubMed, SciELO, LILACS, Ovid and Google Scholar, respectively. After applying the inclusion and exclusion criteria, 67 studies were selected and analyzed for quality. The quality assessment revealed 9 papers in category A, which were included in the present systematic review (Table 3). Of these papers, eight received 8 points and only one received 9 points. The data from the selected studies are listed in Table 3. Among the most relevant data, the size of the target population was considered to be very discrepant, ranging from 107 to 4,674 patients.


Methicillin-resistant Staphylococcus aureus in HIV patients: risk factors associated with colonization and/or infection and methods for characterization of isolates - a systematic review.

Ferreira Dde C, Silva GR, Cavalcante FS, Carmo FL, Fernandes LA, Moreira S, Passos MR, Colombo AP, Santos KR - Clinics (Sao Paulo) (2014)

- Outline of the steps for the selection of the studies.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4256048&req=5

f1-cln_69p770: - Outline of the steps for the selection of the studies.
Mentions: Figure 1 outlines the steps for the selection of the studies. The number of articles found in and selected from the databases is listed in Table 2. An initial electronic search of the health sciences databases using the keywords uncovered a total of 911, 29, 841, 11 and 1,115 articles from PubMed, SciELO, LILACS, Ovid and Google Scholar, respectively. After applying the inclusion and exclusion criteria, 67 studies were selected and analyzed for quality. The quality assessment revealed 9 papers in category A, which were included in the present systematic review (Table 3). Of these papers, eight received 8 points and only one received 9 points. The data from the selected studies are listed in Table 3. Among the most relevant data, the size of the target population was considered to be very discrepant, ranging from 107 to 4,674 patients.

Bottom Line: Genotypic profiles were accessed by pulsed-field gel electrophoresis (6/9 studies) and USA300 was the most prevalent lineage (5/9 studies).Most isolates were resistant to erythromycin (3/9 studies) and susceptible to vancomycin (4/9 studies).However, the numbers of evaluated patients, the exclusion and inclusion criteria and the characterization of the S. aureus isolates were not uniform, which made it difficult to establish the characteristics associated with HIV patients who are colonized/infected by S. aureus.

View Article: PubMed Central - PubMed

Affiliation: Bolsista da Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES), CAPES Foundation, Brasilia, DF, Brazil.

ABSTRACT
Staphylococcus aureus is an important cause of infections and HIV-infected individuals are frequently susceptible to this pathogen. The aim of this study was to perform a systematic review to identify both the risk factors associated with colonization/infection by methicillin-resistant S. aureus in HIV patients and the methods used for characterization of isolates. An electronic search of articles published between January 2001 and December 2013 was first conducted. Among 116 studies categorized as being at a quality level of A, B or C, only 9 studies were considered to have high methodological quality (level A). The majority of these studies were retrospective (4/9 studies). The risk factors associated with colonization/infection by S. aureus were use of antimicrobials (4/9 studies), previous hospitalization (4/9 studies) and low CD4+ T lymphocyte counts (<200 cells/μl) (3/9 studies). Culture in mannitol salt agar (3/9 studies) and the latex agglutination test (5/9 studies) were the main methods used for bacterial phenotypic identification. Genotypic profiles were accessed by pulsed-field gel electrophoresis (6/9 studies) and USA300 was the most prevalent lineage (5/9 studies). Most isolates were resistant to erythromycin (3/9 studies) and susceptible to vancomycin (4/9 studies). Ultimately, use of antimicrobials and previous hospitalization were the main risk factors for colonization/infection by methicillin-resistant S. aureus in HIV-infected individuals. However, the numbers of evaluated patients, the exclusion and inclusion criteria and the characterization of the S. aureus isolates were not uniform, which made it difficult to establish the characteristics associated with HIV patients who are colonized/infected by S. aureus.

Show MeSH
Related in: MedlinePlus