Limits...
Evaluation of Osseointegration around Tibial Implants in Rats by Ibandronate-Treated Nanotubular Ti-32Nb-5Zr Alloy.

Nepal M, Li L, Bae TS, Kim BI, Soh Y - Biomol Ther (Seoul) (2014)

Bottom Line: Similarly, higher bone contact and a larger percentage bone area were observed via histology compared to untreated alloy.Furthermore, well coating of ibandronate with alloy was observed by vitro releasing experiment.Our study provided evidences that the coating of bisphosphonate onto the anodized and heat-treated nanostructure of titanium alloy had a positive effect on implant fixation.

View Article: PubMed Central - PubMed

Affiliation: Department of Dental Pharmacology, School of Dentistry, and Institute of Oral Bioscience, Brain Korea 21 Project.

ABSTRACT
Materials with differing surfaces have been developed for clinical implant therapy in dentistry and orthopedics. This study was designed to evaluate bone response to titanium alloy containing Ti-32Nb-5Zr with nanostructure, anodic oxidation, heat treatment, and ibandronate coating. Rats were randomly assigned to two groups for implantation of titanium alloy (untreated) as the control group and titanium alloy group coated with ibandronate as the experimental group. Then, the implants were inserted in both tibiae of the rats for four weeks. After implantation, bone implant interface, trabecular microstructure, mechanical fixation was evaluated by histology, micro-computed tomography (μCT) and the push-out test, respectively. We found that the anodized, heat-treated and ibandronate-coated titanium alloy triggered pronounced bone implant integration and early bone formation. Ibandronate-coated implants showed elevated values for removal torque and a higher level of BV/TV, trabecular thickness and separation upon analysis with μCT and mechanical testing. Similarly, higher bone contact and a larger percentage bone area were observed via histology compared to untreated alloy. Furthermore, well coating of ibandronate with alloy was observed by vitro releasing experiment. Our study provided evidences that the coating of bisphosphonate onto the anodized and heat-treated nanostructure of titanium alloy had a positive effect on implant fixation.

No MeSH data available.


Related in: MedlinePlus

Interfacial shear strength between control and titanium alloy. Four weeks after implantation, the mechanical fixation of control and nanotubular titanium alloy coated with ibandronate was measured via the push-out test, respectively. Data are expressed as mean ± S.E.M. *p<0.05 vs. the control.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
getmorefigures.php?uid=PMC4256038&req=5

f4-bt-22-563: Interfacial shear strength between control and titanium alloy. Four weeks after implantation, the mechanical fixation of control and nanotubular titanium alloy coated with ibandronate was measured via the push-out test, respectively. Data are expressed as mean ± S.E.M. *p<0.05 vs. the control.

Mentions: To determine the integration between the implant and the bone, we evaluated mechanical force using a push-out assay. Implants placed in the bone exerted noticeable force between the bone and the implant. The ibandronate-coated and heat-treated alloys showed the maximal push-out force and ultimate shear strength. The maximum mean force for the control alloy was about 0.4 Mpa, while for heat and ibandronate-coated implant, the mean force was about 4 Mpa, 10-fold greater than the control implants (Fig. 4). This force indicates strong osseointegration between ibandronate-treated implants and bone. From this result, we concluded that heat treatment along with biphosphonate coating not only improved implant integration to the bone but also promoted early bone formation from one week to four weeks postoperatively, which can ultimately treat implant loosening.


Evaluation of Osseointegration around Tibial Implants in Rats by Ibandronate-Treated Nanotubular Ti-32Nb-5Zr Alloy.

Nepal M, Li L, Bae TS, Kim BI, Soh Y - Biomol Ther (Seoul) (2014)

Interfacial shear strength between control and titanium alloy. Four weeks after implantation, the mechanical fixation of control and nanotubular titanium alloy coated with ibandronate was measured via the push-out test, respectively. Data are expressed as mean ± S.E.M. *p<0.05 vs. the control.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4256038&req=5

f4-bt-22-563: Interfacial shear strength between control and titanium alloy. Four weeks after implantation, the mechanical fixation of control and nanotubular titanium alloy coated with ibandronate was measured via the push-out test, respectively. Data are expressed as mean ± S.E.M. *p<0.05 vs. the control.
Mentions: To determine the integration between the implant and the bone, we evaluated mechanical force using a push-out assay. Implants placed in the bone exerted noticeable force between the bone and the implant. The ibandronate-coated and heat-treated alloys showed the maximal push-out force and ultimate shear strength. The maximum mean force for the control alloy was about 0.4 Mpa, while for heat and ibandronate-coated implant, the mean force was about 4 Mpa, 10-fold greater than the control implants (Fig. 4). This force indicates strong osseointegration between ibandronate-treated implants and bone. From this result, we concluded that heat treatment along with biphosphonate coating not only improved implant integration to the bone but also promoted early bone formation from one week to four weeks postoperatively, which can ultimately treat implant loosening.

Bottom Line: Similarly, higher bone contact and a larger percentage bone area were observed via histology compared to untreated alloy.Furthermore, well coating of ibandronate with alloy was observed by vitro releasing experiment.Our study provided evidences that the coating of bisphosphonate onto the anodized and heat-treated nanostructure of titanium alloy had a positive effect on implant fixation.

View Article: PubMed Central - PubMed

Affiliation: Department of Dental Pharmacology, School of Dentistry, and Institute of Oral Bioscience, Brain Korea 21 Project.

ABSTRACT
Materials with differing surfaces have been developed for clinical implant therapy in dentistry and orthopedics. This study was designed to evaluate bone response to titanium alloy containing Ti-32Nb-5Zr with nanostructure, anodic oxidation, heat treatment, and ibandronate coating. Rats were randomly assigned to two groups for implantation of titanium alloy (untreated) as the control group and titanium alloy group coated with ibandronate as the experimental group. Then, the implants were inserted in both tibiae of the rats for four weeks. After implantation, bone implant interface, trabecular microstructure, mechanical fixation was evaluated by histology, micro-computed tomography (μCT) and the push-out test, respectively. We found that the anodized, heat-treated and ibandronate-coated titanium alloy triggered pronounced bone implant integration and early bone formation. Ibandronate-coated implants showed elevated values for removal torque and a higher level of BV/TV, trabecular thickness and separation upon analysis with μCT and mechanical testing. Similarly, higher bone contact and a larger percentage bone area were observed via histology compared to untreated alloy. Furthermore, well coating of ibandronate with alloy was observed by vitro releasing experiment. Our study provided evidences that the coating of bisphosphonate onto the anodized and heat-treated nanostructure of titanium alloy had a positive effect on implant fixation.

No MeSH data available.


Related in: MedlinePlus