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Dependence potential of tramadol: behavioral pharmacology in rodents.

Cha HJ, Song MJ, Lee KW, Kim EJ, Kim YH, Lee Y, Seong WK, Hong SI, Jang CG, Yoo HS, Jeong HS - Biomol Ther (Seoul) (2014)

Bottom Line: In this study, we examined the dependence potential and abuse liability of tramadol as well as its effect on the dopaminergic and serotonergic systems in rodents.In animal behavioral tests, tramadol did not show any positive effects on the experimental animals in climbing, jumping, and head twitch tests.However, in the conditioned place preference and self-administration tests, the experimental animals showed significant positive responses.

View Article: PubMed Central - PubMed

Affiliation: Pharmacological Research Division, Toxicological Evaluation and Research Department, National Institute of Food and Drug Safety Evaluation, Ministry of Food and Drug Safety, Chungju 361-709 ; Department of Infectious Diseases, College of Veterinary Medicine, Seoul National University, Seoul 151-742, Republic of Korea.

ABSTRACT
Tramadol is an opioid analgesic agent that has been the subject of a series of case reports suggesting potential for misuse or abuse. However, it is not a controlled substance and is not generally considered addictive in Korea. In this study, we examined the dependence potential and abuse liability of tramadol as well as its effect on the dopaminergic and serotonergic systems in rodents. In animal behavioral tests, tramadol did not show any positive effects on the experimental animals in climbing, jumping, and head twitch tests. However, in the conditioned place preference and self-administration tests, the experimental animals showed significant positive responses. Taken together, tramadol affected the neurological systems related to abuse liability and has the potential to lead psychological dependence.

No MeSH data available.


Related in: MedlinePlus

The animals were administered tramadol (at 0.3, 0.7 or 1.5 mg/kg/0.1 ml per infusion) for 6 sec followed by a 20 sec timeout period in the way of self-administration. Lever responses were performed everyday for more than 7 days. Data are expressed as mean ± standard error (n=6 or 8), and the t-test was used for statistical analysis (*p<0.05 as compared with the saline treated group).
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f5-bt-22-558: The animals were administered tramadol (at 0.3, 0.7 or 1.5 mg/kg/0.1 ml per infusion) for 6 sec followed by a 20 sec timeout period in the way of self-administration. Lever responses were performed everyday for more than 7 days. Data are expressed as mean ± standard error (n=6 or 8), and the t-test was used for statistical analysis (*p<0.05 as compared with the saline treated group).

Mentions: The self-administration test was maintained on a FR 1 schedule for >7 days, and the responses on the active lever were checked on a daily basis. The saline-treated group did not show active responses. Interestingly, the experimental rats in all three tramadol-treated groups showed increased self-administration and significant active responses compared with those of the saline-treated group (Fig. 5).


Dependence potential of tramadol: behavioral pharmacology in rodents.

Cha HJ, Song MJ, Lee KW, Kim EJ, Kim YH, Lee Y, Seong WK, Hong SI, Jang CG, Yoo HS, Jeong HS - Biomol Ther (Seoul) (2014)

The animals were administered tramadol (at 0.3, 0.7 or 1.5 mg/kg/0.1 ml per infusion) for 6 sec followed by a 20 sec timeout period in the way of self-administration. Lever responses were performed everyday for more than 7 days. Data are expressed as mean ± standard error (n=6 or 8), and the t-test was used for statistical analysis (*p<0.05 as compared with the saline treated group).
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4256037&req=5

f5-bt-22-558: The animals were administered tramadol (at 0.3, 0.7 or 1.5 mg/kg/0.1 ml per infusion) for 6 sec followed by a 20 sec timeout period in the way of self-administration. Lever responses were performed everyday for more than 7 days. Data are expressed as mean ± standard error (n=6 or 8), and the t-test was used for statistical analysis (*p<0.05 as compared with the saline treated group).
Mentions: The self-administration test was maintained on a FR 1 schedule for >7 days, and the responses on the active lever were checked on a daily basis. The saline-treated group did not show active responses. Interestingly, the experimental rats in all three tramadol-treated groups showed increased self-administration and significant active responses compared with those of the saline-treated group (Fig. 5).

Bottom Line: In this study, we examined the dependence potential and abuse liability of tramadol as well as its effect on the dopaminergic and serotonergic systems in rodents.In animal behavioral tests, tramadol did not show any positive effects on the experimental animals in climbing, jumping, and head twitch tests.However, in the conditioned place preference and self-administration tests, the experimental animals showed significant positive responses.

View Article: PubMed Central - PubMed

Affiliation: Pharmacological Research Division, Toxicological Evaluation and Research Department, National Institute of Food and Drug Safety Evaluation, Ministry of Food and Drug Safety, Chungju 361-709 ; Department of Infectious Diseases, College of Veterinary Medicine, Seoul National University, Seoul 151-742, Republic of Korea.

ABSTRACT
Tramadol is an opioid analgesic agent that has been the subject of a series of case reports suggesting potential for misuse or abuse. However, it is not a controlled substance and is not generally considered addictive in Korea. In this study, we examined the dependence potential and abuse liability of tramadol as well as its effect on the dopaminergic and serotonergic systems in rodents. In animal behavioral tests, tramadol did not show any positive effects on the experimental animals in climbing, jumping, and head twitch tests. However, in the conditioned place preference and self-administration tests, the experimental animals showed significant positive responses. Taken together, tramadol affected the neurological systems related to abuse liability and has the potential to lead psychological dependence.

No MeSH data available.


Related in: MedlinePlus