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Dependence potential of tramadol: behavioral pharmacology in rodents.

Cha HJ, Song MJ, Lee KW, Kim EJ, Kim YH, Lee Y, Seong WK, Hong SI, Jang CG, Yoo HS, Jeong HS - Biomol Ther (Seoul) (2014)

Bottom Line: In this study, we examined the dependence potential and abuse liability of tramadol as well as its effect on the dopaminergic and serotonergic systems in rodents.In animal behavioral tests, tramadol did not show any positive effects on the experimental animals in climbing, jumping, and head twitch tests.However, in the conditioned place preference and self-administration tests, the experimental animals showed significant positive responses.

View Article: PubMed Central - PubMed

Affiliation: Pharmacological Research Division, Toxicological Evaluation and Research Department, National Institute of Food and Drug Safety Evaluation, Ministry of Food and Drug Safety, Chungju 361-709 ; Department of Infectious Diseases, College of Veterinary Medicine, Seoul National University, Seoul 151-742, Republic of Korea.

ABSTRACT
Tramadol is an opioid analgesic agent that has been the subject of a series of case reports suggesting potential for misuse or abuse. However, it is not a controlled substance and is not generally considered addictive in Korea. In this study, we examined the dependence potential and abuse liability of tramadol as well as its effect on the dopaminergic and serotonergic systems in rodents. In animal behavioral tests, tramadol did not show any positive effects on the experimental animals in climbing, jumping, and head twitch tests. However, in the conditioned place preference and self-administration tests, the experimental animals showed significant positive responses. Taken together, tramadol affected the neurological systems related to abuse liability and has the potential to lead psychological dependence.

No MeSH data available.


Related in: MedlinePlus

Mice were preconditioned for 2 days without drug treatment. Then tramadol (A (0.5 mg/kg), B (1.47 mg/kg) or C (2.94 mg/ kg), intraperitoneally [i.p.]), saline ((−) control, 1 ml, i.p.) and meth-amphetamine ((+) control, 1 mg/kg, i.p.) were administered to the mice once every other day for 8 days. Place preference was measured the next day after the conditioning period. Data are mean ± standard error (n=10). *p<0.05, compared with saline treated group.
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f4-bt-22-558: Mice were preconditioned for 2 days without drug treatment. Then tramadol (A (0.5 mg/kg), B (1.47 mg/kg) or C (2.94 mg/ kg), intraperitoneally [i.p.]), saline ((−) control, 1 ml, i.p.) and meth-amphetamine ((+) control, 1 mg/kg, i.p.) were administered to the mice once every other day for 8 days. Place preference was measured the next day after the conditioning period. Data are mean ± standard error (n=10). *p<0.05, compared with saline treated group.

Mentions: The possibility for psychological dependency or abuse liability was evaluated through conditioned place preference and self-administration. Considering the overall results, the animal’s place preference clearly changed in every group during the 8 day-conditioning period. In contrast with the mice treated with saline, the entire group treated with drugs (tramadol and methamphetamine) spent more time in the undesirable room after the conditioning period. When the differences were compared between the saline-treated and drug-treated groups, the animals that received tramadol showed a dose-dependent pattern and significant place preference scores (Fig. 4).


Dependence potential of tramadol: behavioral pharmacology in rodents.

Cha HJ, Song MJ, Lee KW, Kim EJ, Kim YH, Lee Y, Seong WK, Hong SI, Jang CG, Yoo HS, Jeong HS - Biomol Ther (Seoul) (2014)

Mice were preconditioned for 2 days without drug treatment. Then tramadol (A (0.5 mg/kg), B (1.47 mg/kg) or C (2.94 mg/ kg), intraperitoneally [i.p.]), saline ((−) control, 1 ml, i.p.) and meth-amphetamine ((+) control, 1 mg/kg, i.p.) were administered to the mice once every other day for 8 days. Place preference was measured the next day after the conditioning period. Data are mean ± standard error (n=10). *p<0.05, compared with saline treated group.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4256037&req=5

f4-bt-22-558: Mice were preconditioned for 2 days without drug treatment. Then tramadol (A (0.5 mg/kg), B (1.47 mg/kg) or C (2.94 mg/ kg), intraperitoneally [i.p.]), saline ((−) control, 1 ml, i.p.) and meth-amphetamine ((+) control, 1 mg/kg, i.p.) were administered to the mice once every other day for 8 days. Place preference was measured the next day after the conditioning period. Data are mean ± standard error (n=10). *p<0.05, compared with saline treated group.
Mentions: The possibility for psychological dependency or abuse liability was evaluated through conditioned place preference and self-administration. Considering the overall results, the animal’s place preference clearly changed in every group during the 8 day-conditioning period. In contrast with the mice treated with saline, the entire group treated with drugs (tramadol and methamphetamine) spent more time in the undesirable room after the conditioning period. When the differences were compared between the saline-treated and drug-treated groups, the animals that received tramadol showed a dose-dependent pattern and significant place preference scores (Fig. 4).

Bottom Line: In this study, we examined the dependence potential and abuse liability of tramadol as well as its effect on the dopaminergic and serotonergic systems in rodents.In animal behavioral tests, tramadol did not show any positive effects on the experimental animals in climbing, jumping, and head twitch tests.However, in the conditioned place preference and self-administration tests, the experimental animals showed significant positive responses.

View Article: PubMed Central - PubMed

Affiliation: Pharmacological Research Division, Toxicological Evaluation and Research Department, National Institute of Food and Drug Safety Evaluation, Ministry of Food and Drug Safety, Chungju 361-709 ; Department of Infectious Diseases, College of Veterinary Medicine, Seoul National University, Seoul 151-742, Republic of Korea.

ABSTRACT
Tramadol is an opioid analgesic agent that has been the subject of a series of case reports suggesting potential for misuse or abuse. However, it is not a controlled substance and is not generally considered addictive in Korea. In this study, we examined the dependence potential and abuse liability of tramadol as well as its effect on the dopaminergic and serotonergic systems in rodents. In animal behavioral tests, tramadol did not show any positive effects on the experimental animals in climbing, jumping, and head twitch tests. However, in the conditioned place preference and self-administration tests, the experimental animals showed significant positive responses. Taken together, tramadol affected the neurological systems related to abuse liability and has the potential to lead psychological dependence.

No MeSH data available.


Related in: MedlinePlus