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Dependence potential of tramadol: behavioral pharmacology in rodents.

Cha HJ, Song MJ, Lee KW, Kim EJ, Kim YH, Lee Y, Seong WK, Hong SI, Jang CG, Yoo HS, Jeong HS - Biomol Ther (Seoul) (2014)

Bottom Line: In this study, we examined the dependence potential and abuse liability of tramadol as well as its effect on the dopaminergic and serotonergic systems in rodents.In animal behavioral tests, tramadol did not show any positive effects on the experimental animals in climbing, jumping, and head twitch tests.However, in the conditioned place preference and self-administration tests, the experimental animals showed significant positive responses.

View Article: PubMed Central - PubMed

Affiliation: Pharmacological Research Division, Toxicological Evaluation and Research Department, National Institute of Food and Drug Safety Evaluation, Ministry of Food and Drug Safety, Chungju 361-709 ; Department of Infectious Diseases, College of Veterinary Medicine, Seoul National University, Seoul 151-742, Republic of Korea.

ABSTRACT
Tramadol is an opioid analgesic agent that has been the subject of a series of case reports suggesting potential for misuse or abuse. However, it is not a controlled substance and is not generally considered addictive in Korea. In this study, we examined the dependence potential and abuse liability of tramadol as well as its effect on the dopaminergic and serotonergic systems in rodents. In animal behavioral tests, tramadol did not show any positive effects on the experimental animals in climbing, jumping, and head twitch tests. However, in the conditioned place preference and self-administration tests, the experimental animals showed significant positive responses. Taken together, tramadol affected the neurological systems related to abuse liability and has the potential to lead psychological dependence.

No MeSH data available.


Related in: MedlinePlus

Tramadol (A (0.01 mg/kg), B (0.03 mg/kg) or C (0.07 mg/ kg), i.p.) was injected prior to serotonin (5-HT, 3–4 mg/kg, intracerebroventricularly) administration (after serotonin treatment: control’, A′ (0.01 mg/kg), B′ (0.03 mg/kg), C′ (0.07 mg/kg), i.p.). The response scores in the groups (n=14) were measured for 2 min, three times at 10 min of intervals. Each value is mean ± standard error. *p<0.05 compared with saline treated group.
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f3-bt-22-558: Tramadol (A (0.01 mg/kg), B (0.03 mg/kg) or C (0.07 mg/ kg), i.p.) was injected prior to serotonin (5-HT, 3–4 mg/kg, intracerebroventricularly) administration (after serotonin treatment: control’, A′ (0.01 mg/kg), B′ (0.03 mg/kg), C′ (0.07 mg/kg), i.p.). The response scores in the groups (n=14) were measured for 2 min, three times at 10 min of intervals. Each value is mean ± standard error. *p<0.05 compared with saline treated group.

Mentions: The head twitch response was observed to evaluate the serotonergic effect of tramadol. One of the three doses of tramadol (0.01, 0.03, or 0.07 mg/kg, i.p.) was administered prior to administering serotonin (5-HT, 3-4 mg/kg, i.c.v.). We counted responses in each of the groups three times, for 2 min each, with 10 min intervals. As shown in Fig. 3, no mice in either the saline-treated group or the tramadol treated groups showed a head twitch response in the absence of serotonin. In contrast, the tramadol-treated groups showed a tendency for increasing responses compared with that in the saline-treated group. However, only one tramadol-treated group (0.07 mg/ kg) showed a significant increase (Fig. 3).


Dependence potential of tramadol: behavioral pharmacology in rodents.

Cha HJ, Song MJ, Lee KW, Kim EJ, Kim YH, Lee Y, Seong WK, Hong SI, Jang CG, Yoo HS, Jeong HS - Biomol Ther (Seoul) (2014)

Tramadol (A (0.01 mg/kg), B (0.03 mg/kg) or C (0.07 mg/ kg), i.p.) was injected prior to serotonin (5-HT, 3–4 mg/kg, intracerebroventricularly) administration (after serotonin treatment: control’, A′ (0.01 mg/kg), B′ (0.03 mg/kg), C′ (0.07 mg/kg), i.p.). The response scores in the groups (n=14) were measured for 2 min, three times at 10 min of intervals. Each value is mean ± standard error. *p<0.05 compared with saline treated group.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4256037&req=5

f3-bt-22-558: Tramadol (A (0.01 mg/kg), B (0.03 mg/kg) or C (0.07 mg/ kg), i.p.) was injected prior to serotonin (5-HT, 3–4 mg/kg, intracerebroventricularly) administration (after serotonin treatment: control’, A′ (0.01 mg/kg), B′ (0.03 mg/kg), C′ (0.07 mg/kg), i.p.). The response scores in the groups (n=14) were measured for 2 min, three times at 10 min of intervals. Each value is mean ± standard error. *p<0.05 compared with saline treated group.
Mentions: The head twitch response was observed to evaluate the serotonergic effect of tramadol. One of the three doses of tramadol (0.01, 0.03, or 0.07 mg/kg, i.p.) was administered prior to administering serotonin (5-HT, 3-4 mg/kg, i.c.v.). We counted responses in each of the groups three times, for 2 min each, with 10 min intervals. As shown in Fig. 3, no mice in either the saline-treated group or the tramadol treated groups showed a head twitch response in the absence of serotonin. In contrast, the tramadol-treated groups showed a tendency for increasing responses compared with that in the saline-treated group. However, only one tramadol-treated group (0.07 mg/ kg) showed a significant increase (Fig. 3).

Bottom Line: In this study, we examined the dependence potential and abuse liability of tramadol as well as its effect on the dopaminergic and serotonergic systems in rodents.In animal behavioral tests, tramadol did not show any positive effects on the experimental animals in climbing, jumping, and head twitch tests.However, in the conditioned place preference and self-administration tests, the experimental animals showed significant positive responses.

View Article: PubMed Central - PubMed

Affiliation: Pharmacological Research Division, Toxicological Evaluation and Research Department, National Institute of Food and Drug Safety Evaluation, Ministry of Food and Drug Safety, Chungju 361-709 ; Department of Infectious Diseases, College of Veterinary Medicine, Seoul National University, Seoul 151-742, Republic of Korea.

ABSTRACT
Tramadol is an opioid analgesic agent that has been the subject of a series of case reports suggesting potential for misuse or abuse. However, it is not a controlled substance and is not generally considered addictive in Korea. In this study, we examined the dependence potential and abuse liability of tramadol as well as its effect on the dopaminergic and serotonergic systems in rodents. In animal behavioral tests, tramadol did not show any positive effects on the experimental animals in climbing, jumping, and head twitch tests. However, in the conditioned place preference and self-administration tests, the experimental animals showed significant positive responses. Taken together, tramadol affected the neurological systems related to abuse liability and has the potential to lead psychological dependence.

No MeSH data available.


Related in: MedlinePlus