Limits...
Dependence potential of tramadol: behavioral pharmacology in rodents.

Cha HJ, Song MJ, Lee KW, Kim EJ, Kim YH, Lee Y, Seong WK, Hong SI, Jang CG, Yoo HS, Jeong HS - Biomol Ther (Seoul) (2014)

Bottom Line: In this study, we examined the dependence potential and abuse liability of tramadol as well as its effect on the dopaminergic and serotonergic systems in rodents.In animal behavioral tests, tramadol did not show any positive effects on the experimental animals in climbing, jumping, and head twitch tests.However, in the conditioned place preference and self-administration tests, the experimental animals showed significant positive responses.

View Article: PubMed Central - PubMed

Affiliation: Pharmacological Research Division, Toxicological Evaluation and Research Department, National Institute of Food and Drug Safety Evaluation, Ministry of Food and Drug Safety, Chungju 361-709 ; Department of Infectious Diseases, College of Veterinary Medicine, Seoul National University, Seoul 151-742, Republic of Korea.

ABSTRACT
Tramadol is an opioid analgesic agent that has been the subject of a series of case reports suggesting potential for misuse or abuse. However, it is not a controlled substance and is not generally considered addictive in Korea. In this study, we examined the dependence potential and abuse liability of tramadol as well as its effect on the dopaminergic and serotonergic systems in rodents. In animal behavioral tests, tramadol did not show any positive effects on the experimental animals in climbing, jumping, and head twitch tests. However, in the conditioned place preference and self-administration tests, the experimental animals showed significant positive responses. Taken together, tramadol affected the neurological systems related to abuse liability and has the potential to lead psychological dependence.

No MeSH data available.


Related in: MedlinePlus

Tramadol (A (0.03 mg/kg), B (0.07 mg/kg) or C (0.1 mg/kg), intraperitoneally [i.p.]) was administered prior to morphine administration. Morphine (150 mg/kg, subcutaneously) was administered 4 hr prior to naloxone administration (after morphine treatment: control’, A′ (0.03 mg/kg), B′ (0.07 mg/kg), C′ (0.1 mg/kg), i.p.). The jumping score in groups (n=15) was measured for 15 min immediately after injection of naloxone (10 mg/kg, i.p.). Each value is mean ± standard error. *<0.05 compared with saline treated group.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
getmorefigures.php?uid=PMC4256037&req=5

f2-bt-22-558: Tramadol (A (0.03 mg/kg), B (0.07 mg/kg) or C (0.1 mg/kg), intraperitoneally [i.p.]) was administered prior to morphine administration. Morphine (150 mg/kg, subcutaneously) was administered 4 hr prior to naloxone administration (after morphine treatment: control’, A′ (0.03 mg/kg), B′ (0.07 mg/kg), C′ (0.1 mg/kg), i.p.). The jumping score in groups (n=15) was measured for 15 min immediately after injection of naloxone (10 mg/kg, i.p.). Each value is mean ± standard error. *<0.05 compared with saline treated group.

Mentions: The jumping test was performed to determine if tramadol showed withdrawal syndrome. We administered the saline (1 mg/kg, i.p.) or one of three doses of tramadol (0.03, 0.07, or 0.1 mg/kg, i.p.) prior to administering morphine. The mice received morphine (150 mg/kg, subcutaneously) 4 hr before naloxone (10 mg/kg, i.p.). As shown in Fig. 2, two groups of tramadol-treated mice (0.03 and 0.07 mg/kg) showed the jumping behavior, but the difference between the saline-treated group and tramadol-treated group was not significant. In the morphine-pretreated groups, two of tramadol-treated groups jumped more than saline-treated group; one tramadol-treated group showed a statistically significant increase (0.03 mg/kg). The results are depicted in Fig. 2.


Dependence potential of tramadol: behavioral pharmacology in rodents.

Cha HJ, Song MJ, Lee KW, Kim EJ, Kim YH, Lee Y, Seong WK, Hong SI, Jang CG, Yoo HS, Jeong HS - Biomol Ther (Seoul) (2014)

Tramadol (A (0.03 mg/kg), B (0.07 mg/kg) or C (0.1 mg/kg), intraperitoneally [i.p.]) was administered prior to morphine administration. Morphine (150 mg/kg, subcutaneously) was administered 4 hr prior to naloxone administration (after morphine treatment: control’, A′ (0.03 mg/kg), B′ (0.07 mg/kg), C′ (0.1 mg/kg), i.p.). The jumping score in groups (n=15) was measured for 15 min immediately after injection of naloxone (10 mg/kg, i.p.). Each value is mean ± standard error. *<0.05 compared with saline treated group.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4256037&req=5

f2-bt-22-558: Tramadol (A (0.03 mg/kg), B (0.07 mg/kg) or C (0.1 mg/kg), intraperitoneally [i.p.]) was administered prior to morphine administration. Morphine (150 mg/kg, subcutaneously) was administered 4 hr prior to naloxone administration (after morphine treatment: control’, A′ (0.03 mg/kg), B′ (0.07 mg/kg), C′ (0.1 mg/kg), i.p.). The jumping score in groups (n=15) was measured for 15 min immediately after injection of naloxone (10 mg/kg, i.p.). Each value is mean ± standard error. *<0.05 compared with saline treated group.
Mentions: The jumping test was performed to determine if tramadol showed withdrawal syndrome. We administered the saline (1 mg/kg, i.p.) or one of three doses of tramadol (0.03, 0.07, or 0.1 mg/kg, i.p.) prior to administering morphine. The mice received morphine (150 mg/kg, subcutaneously) 4 hr before naloxone (10 mg/kg, i.p.). As shown in Fig. 2, two groups of tramadol-treated mice (0.03 and 0.07 mg/kg) showed the jumping behavior, but the difference between the saline-treated group and tramadol-treated group was not significant. In the morphine-pretreated groups, two of tramadol-treated groups jumped more than saline-treated group; one tramadol-treated group showed a statistically significant increase (0.03 mg/kg). The results are depicted in Fig. 2.

Bottom Line: In this study, we examined the dependence potential and abuse liability of tramadol as well as its effect on the dopaminergic and serotonergic systems in rodents.In animal behavioral tests, tramadol did not show any positive effects on the experimental animals in climbing, jumping, and head twitch tests.However, in the conditioned place preference and self-administration tests, the experimental animals showed significant positive responses.

View Article: PubMed Central - PubMed

Affiliation: Pharmacological Research Division, Toxicological Evaluation and Research Department, National Institute of Food and Drug Safety Evaluation, Ministry of Food and Drug Safety, Chungju 361-709 ; Department of Infectious Diseases, College of Veterinary Medicine, Seoul National University, Seoul 151-742, Republic of Korea.

ABSTRACT
Tramadol is an opioid analgesic agent that has been the subject of a series of case reports suggesting potential for misuse or abuse. However, it is not a controlled substance and is not generally considered addictive in Korea. In this study, we examined the dependence potential and abuse liability of tramadol as well as its effect on the dopaminergic and serotonergic systems in rodents. In animal behavioral tests, tramadol did not show any positive effects on the experimental animals in climbing, jumping, and head twitch tests. However, in the conditioned place preference and self-administration tests, the experimental animals showed significant positive responses. Taken together, tramadol affected the neurological systems related to abuse liability and has the potential to lead psychological dependence.

No MeSH data available.


Related in: MedlinePlus