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Dependence potential of tramadol: behavioral pharmacology in rodents.

Cha HJ, Song MJ, Lee KW, Kim EJ, Kim YH, Lee Y, Seong WK, Hong SI, Jang CG, Yoo HS, Jeong HS - Biomol Ther (Seoul) (2014)

Bottom Line: In this study, we examined the dependence potential and abuse liability of tramadol as well as its effect on the dopaminergic and serotonergic systems in rodents.In animal behavioral tests, tramadol did not show any positive effects on the experimental animals in climbing, jumping, and head twitch tests.However, in the conditioned place preference and self-administration tests, the experimental animals showed significant positive responses.

View Article: PubMed Central - PubMed

Affiliation: Pharmacological Research Division, Toxicological Evaluation and Research Department, National Institute of Food and Drug Safety Evaluation, Ministry of Food and Drug Safety, Chungju 361-709 ; Department of Infectious Diseases, College of Veterinary Medicine, Seoul National University, Seoul 151-742, Republic of Korea.

ABSTRACT
Tramadol is an opioid analgesic agent that has been the subject of a series of case reports suggesting potential for misuse or abuse. However, it is not a controlled substance and is not generally considered addictive in Korea. In this study, we examined the dependence potential and abuse liability of tramadol as well as its effect on the dopaminergic and serotonergic systems in rodents. In animal behavioral tests, tramadol did not show any positive effects on the experimental animals in climbing, jumping, and head twitch tests. However, in the conditioned place preference and self-administration tests, the experimental animals showed significant positive responses. Taken together, tramadol affected the neurological systems related to abuse liability and has the potential to lead psychological dependence.

No MeSH data available.


Related in: MedlinePlus

Climbing behaviors were measured after injection of apomorphine to each subject (2 mg/kg, subcutaneously). The pre-treatments were tramadol (A (0.03 mg/kg), B (0.07 mg/kg) or C (0.1 mg/kg), intraperitoneally), administered before the apomorphine treatment (after apomorphine treatment: control’, A′ (0.03 mg/kg), B′ (0.07 mg/kg), C′ (0.1 mg/kg), i.p.). Data are mean ± standard error (n=15).
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f1-bt-22-558: Climbing behaviors were measured after injection of apomorphine to each subject (2 mg/kg, subcutaneously). The pre-treatments were tramadol (A (0.03 mg/kg), B (0.07 mg/kg) or C (0.1 mg/kg), intraperitoneally), administered before the apomorphine treatment (after apomorphine treatment: control’, A′ (0.03 mg/kg), B′ (0.07 mg/kg), C′ (0.1 mg/kg), i.p.). Data are mean ± standard error (n=15).

Mentions: We measured climbing behavior in the experimental mice with or without pre-treatment of the saline (1 mg/kg, i.p.) or tramadol (0.03, 0.07, or 0.1 mg/kg, i.p.) to determine whether tramadol affects the dopaminergic system. No differences were observed between the saline treated group and the tramadol treated groups, regardless of drug concentration with or without apomorphine treatment (Fig. 1).


Dependence potential of tramadol: behavioral pharmacology in rodents.

Cha HJ, Song MJ, Lee KW, Kim EJ, Kim YH, Lee Y, Seong WK, Hong SI, Jang CG, Yoo HS, Jeong HS - Biomol Ther (Seoul) (2014)

Climbing behaviors were measured after injection of apomorphine to each subject (2 mg/kg, subcutaneously). The pre-treatments were tramadol (A (0.03 mg/kg), B (0.07 mg/kg) or C (0.1 mg/kg), intraperitoneally), administered before the apomorphine treatment (after apomorphine treatment: control’, A′ (0.03 mg/kg), B′ (0.07 mg/kg), C′ (0.1 mg/kg), i.p.). Data are mean ± standard error (n=15).
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4256037&req=5

f1-bt-22-558: Climbing behaviors were measured after injection of apomorphine to each subject (2 mg/kg, subcutaneously). The pre-treatments were tramadol (A (0.03 mg/kg), B (0.07 mg/kg) or C (0.1 mg/kg), intraperitoneally), administered before the apomorphine treatment (after apomorphine treatment: control’, A′ (0.03 mg/kg), B′ (0.07 mg/kg), C′ (0.1 mg/kg), i.p.). Data are mean ± standard error (n=15).
Mentions: We measured climbing behavior in the experimental mice with or without pre-treatment of the saline (1 mg/kg, i.p.) or tramadol (0.03, 0.07, or 0.1 mg/kg, i.p.) to determine whether tramadol affects the dopaminergic system. No differences were observed between the saline treated group and the tramadol treated groups, regardless of drug concentration with or without apomorphine treatment (Fig. 1).

Bottom Line: In this study, we examined the dependence potential and abuse liability of tramadol as well as its effect on the dopaminergic and serotonergic systems in rodents.In animal behavioral tests, tramadol did not show any positive effects on the experimental animals in climbing, jumping, and head twitch tests.However, in the conditioned place preference and self-administration tests, the experimental animals showed significant positive responses.

View Article: PubMed Central - PubMed

Affiliation: Pharmacological Research Division, Toxicological Evaluation and Research Department, National Institute of Food and Drug Safety Evaluation, Ministry of Food and Drug Safety, Chungju 361-709 ; Department of Infectious Diseases, College of Veterinary Medicine, Seoul National University, Seoul 151-742, Republic of Korea.

ABSTRACT
Tramadol is an opioid analgesic agent that has been the subject of a series of case reports suggesting potential for misuse or abuse. However, it is not a controlled substance and is not generally considered addictive in Korea. In this study, we examined the dependence potential and abuse liability of tramadol as well as its effect on the dopaminergic and serotonergic systems in rodents. In animal behavioral tests, tramadol did not show any positive effects on the experimental animals in climbing, jumping, and head twitch tests. However, in the conditioned place preference and self-administration tests, the experimental animals showed significant positive responses. Taken together, tramadol affected the neurological systems related to abuse liability and has the potential to lead psychological dependence.

No MeSH data available.


Related in: MedlinePlus