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Lightening up Light Therapy: Activation of Retrograde Signaling Pathway by Photobiomodulation.

Kim HP - Biomol Ther (Seoul) (2014)

Bottom Line: Photobiomodulation utilizes monochromatic (or quasimonochromatic) light in the electromagnetic region of 600∼1000 nm for the treatment of soft tissues in a nondestructive and nonthermal mode.It is conceivable that photobiomodulation is based upon the ability of the light to alter cell metabolism as it is absorbed by general hemoproteins and cytochrome c oxidase (COX) in particular.Further a possible role of water as a photoreceptor will be suggested.

View Article: PubMed Central - PubMed

Affiliation: Ajou University, School of Pharmacy, Suwon 443-749, Republic of Korea.

ABSTRACT
Photobiomodulation utilizes monochromatic (or quasimonochromatic) light in the electromagnetic region of 600∼1000 nm for the treatment of soft tissues in a nondestructive and nonthermal mode. It is conceivable that photobiomodulation is based upon the ability of the light to alter cell metabolism as it is absorbed by general hemoproteins and cytochrome c oxidase (COX) in particular. Recently it has been suggested radiation of visible and infrared (IR) activates retrograde signaling pathway from mitochondria to nucleus. In this review, the role of COX in the photobiomodulation will be discussed. Further a possible role of water as a photoreceptor will be suggested.

No MeSH data available.


Heme-iron axial ligands. Histidine in COX protein and CO or oxygen can be axial ligands. Lights can displace gas molecules with oxygen, which functions as an electron acceptor to make water. Electron transport chain (ETC) located to inner membrane of mitochondria.
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f1-bt-22-491: Heme-iron axial ligands. Histidine in COX protein and CO or oxygen can be axial ligands. Lights can displace gas molecules with oxygen, which functions as an electron acceptor to make water. Electron transport chain (ETC) located to inner membrane of mitochondria.

Mentions: The method that Warburg used to discover is rather intriguing since he has exploited two seemingly unrelated things; carbon monoxide (CO) and light (Lane, 2006). While CO can block cellular respiration by binding and inhibiting COX in place of oxygen, a flash of light can displace the gas molecule. Thus oxygen can bind to the enzyme again and utilize it to produce ATP (Fig. 1). Cells frequently use CO and nitric oxide (NO) to block cellular respiration (Moncada and Bolaños, 2006; Zuckerbraun et al., 2007).


Lightening up Light Therapy: Activation of Retrograde Signaling Pathway by Photobiomodulation.

Kim HP - Biomol Ther (Seoul) (2014)

Heme-iron axial ligands. Histidine in COX protein and CO or oxygen can be axial ligands. Lights can displace gas molecules with oxygen, which functions as an electron acceptor to make water. Electron transport chain (ETC) located to inner membrane of mitochondria.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4256027&req=5

f1-bt-22-491: Heme-iron axial ligands. Histidine in COX protein and CO or oxygen can be axial ligands. Lights can displace gas molecules with oxygen, which functions as an electron acceptor to make water. Electron transport chain (ETC) located to inner membrane of mitochondria.
Mentions: The method that Warburg used to discover is rather intriguing since he has exploited two seemingly unrelated things; carbon monoxide (CO) and light (Lane, 2006). While CO can block cellular respiration by binding and inhibiting COX in place of oxygen, a flash of light can displace the gas molecule. Thus oxygen can bind to the enzyme again and utilize it to produce ATP (Fig. 1). Cells frequently use CO and nitric oxide (NO) to block cellular respiration (Moncada and Bolaños, 2006; Zuckerbraun et al., 2007).

Bottom Line: Photobiomodulation utilizes monochromatic (or quasimonochromatic) light in the electromagnetic region of 600∼1000 nm for the treatment of soft tissues in a nondestructive and nonthermal mode.It is conceivable that photobiomodulation is based upon the ability of the light to alter cell metabolism as it is absorbed by general hemoproteins and cytochrome c oxidase (COX) in particular.Further a possible role of water as a photoreceptor will be suggested.

View Article: PubMed Central - PubMed

Affiliation: Ajou University, School of Pharmacy, Suwon 443-749, Republic of Korea.

ABSTRACT
Photobiomodulation utilizes monochromatic (or quasimonochromatic) light in the electromagnetic region of 600∼1000 nm for the treatment of soft tissues in a nondestructive and nonthermal mode. It is conceivable that photobiomodulation is based upon the ability of the light to alter cell metabolism as it is absorbed by general hemoproteins and cytochrome c oxidase (COX) in particular. Recently it has been suggested radiation of visible and infrared (IR) activates retrograde signaling pathway from mitochondria to nucleus. In this review, the role of COX in the photobiomodulation will be discussed. Further a possible role of water as a photoreceptor will be suggested.

No MeSH data available.