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Non-thermal atmospheric-pressure plasma possible application in wound healing.

Haertel B, von Woedtke T, Weltmann KD, Lindequist U - Biomol Ther (Seoul) (2014)

Bottom Line: Therefore, it cannot be equated with plasma from blood; it is not biological in nature.This review emphasizes plasma effects on wound healing.We summarize the effects of plasma on eukaryotic cells, especially on keratinocytes in terms of viability, proliferation, DNA, adhesion molecules and angiogenesis together with the role of reactive oxygen species and other components of plasma.

View Article: PubMed Central - PubMed

Affiliation: Department of Pharmaceutical Biology, Institute of Pharmacy, Ernst-Moritz-Arndt University of Greifswald, D17489 Greifswald, Germany.

ABSTRACT
Non-thermal atmospheric-pressure plasma, also named cold plasma, is defined as a partly ionized gas. Therefore, it cannot be equated with plasma from blood; it is not biological in nature. Non-thermal atmospheric-pressure plasma is a new innovative approach in medicine not only for the treatment of wounds, but with a wide-range of other applications, as e.g. topical treatment of other skin diseases with microbial involvement or treatment of cancer diseases. This review emphasizes plasma effects on wound healing. Non-thermal atmospheric-pressure plasma can support wound healing by its antiseptic effects, by stimulation of proliferation and migration of wound relating skin cells, by activation or inhibition of integrin receptors on the cell surface or by its pro-angiogenic effect. We summarize the effects of plasma on eukaryotic cells, especially on keratinocytes in terms of viability, proliferation, DNA, adhesion molecules and angiogenesis together with the role of reactive oxygen species and other components of plasma. The outcome of first clinical trials regarding wound healing is pointed out.

No MeSH data available.


Related in: MedlinePlus

Scheme of plasma sources used and the burning plasmas. (A) Plasma jet kINPen 09; (B) Surface DBD and (C) Volume DBD. All plasma sources were developed and built in the Leibniz Institute for Plasma Science and Technology (INP) in Greifswald, Germany.
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f2-bt-22-477: Scheme of plasma sources used and the burning plasmas. (A) Plasma jet kINPen 09; (B) Surface DBD and (C) Volume DBD. All plasma sources were developed and built in the Leibniz Institute for Plasma Science and Technology (INP) in Greifswald, Germany.

Mentions: Our group has been working with experimental plasma sources belonging to two of these principles, the plasma jet kINPen 09 (principle 1; Fig. 2A), surface and volume barrier discharge (DBD) plasma sources (principle 3; Fig. 2B, C). All these plasma sources were developed at the Leibniz Institute for Plasma Science and Technology Greifswald e.V. (INP). Argon (kINPen 09, surface DBD, volume DBD), argon-oxygen mixtures (kINPen 09) or ambient air (surface DBD) were used as operating gas. Technical data of these plasma sources are listed in Table 1. Energy output as sign for the power of a plasma source is lowest for the surface DBD with argon as process gas and highest for the volume DBD. Energy output is directly associated with inducing lethal or non-lethal effects on cells or microorganisms.


Non-thermal atmospheric-pressure plasma possible application in wound healing.

Haertel B, von Woedtke T, Weltmann KD, Lindequist U - Biomol Ther (Seoul) (2014)

Scheme of plasma sources used and the burning plasmas. (A) Plasma jet kINPen 09; (B) Surface DBD and (C) Volume DBD. All plasma sources were developed and built in the Leibniz Institute for Plasma Science and Technology (INP) in Greifswald, Germany.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4256026&req=5

f2-bt-22-477: Scheme of plasma sources used and the burning plasmas. (A) Plasma jet kINPen 09; (B) Surface DBD and (C) Volume DBD. All plasma sources were developed and built in the Leibniz Institute for Plasma Science and Technology (INP) in Greifswald, Germany.
Mentions: Our group has been working with experimental plasma sources belonging to two of these principles, the plasma jet kINPen 09 (principle 1; Fig. 2A), surface and volume barrier discharge (DBD) plasma sources (principle 3; Fig. 2B, C). All these plasma sources were developed at the Leibniz Institute for Plasma Science and Technology Greifswald e.V. (INP). Argon (kINPen 09, surface DBD, volume DBD), argon-oxygen mixtures (kINPen 09) or ambient air (surface DBD) were used as operating gas. Technical data of these plasma sources are listed in Table 1. Energy output as sign for the power of a plasma source is lowest for the surface DBD with argon as process gas and highest for the volume DBD. Energy output is directly associated with inducing lethal or non-lethal effects on cells or microorganisms.

Bottom Line: Therefore, it cannot be equated with plasma from blood; it is not biological in nature.This review emphasizes plasma effects on wound healing.We summarize the effects of plasma on eukaryotic cells, especially on keratinocytes in terms of viability, proliferation, DNA, adhesion molecules and angiogenesis together with the role of reactive oxygen species and other components of plasma.

View Article: PubMed Central - PubMed

Affiliation: Department of Pharmaceutical Biology, Institute of Pharmacy, Ernst-Moritz-Arndt University of Greifswald, D17489 Greifswald, Germany.

ABSTRACT
Non-thermal atmospheric-pressure plasma, also named cold plasma, is defined as a partly ionized gas. Therefore, it cannot be equated with plasma from blood; it is not biological in nature. Non-thermal atmospheric-pressure plasma is a new innovative approach in medicine not only for the treatment of wounds, but with a wide-range of other applications, as e.g. topical treatment of other skin diseases with microbial involvement or treatment of cancer diseases. This review emphasizes plasma effects on wound healing. Non-thermal atmospheric-pressure plasma can support wound healing by its antiseptic effects, by stimulation of proliferation and migration of wound relating skin cells, by activation or inhibition of integrin receptors on the cell surface or by its pro-angiogenic effect. We summarize the effects of plasma on eukaryotic cells, especially on keratinocytes in terms of viability, proliferation, DNA, adhesion molecules and angiogenesis together with the role of reactive oxygen species and other components of plasma. The outcome of first clinical trials regarding wound healing is pointed out.

No MeSH data available.


Related in: MedlinePlus