Limits...
Non-thermal atmospheric-pressure plasma possible application in wound healing.

Haertel B, von Woedtke T, Weltmann KD, Lindequist U - Biomol Ther (Seoul) (2014)

Bottom Line: Therefore, it cannot be equated with plasma from blood; it is not biological in nature.This review emphasizes plasma effects on wound healing.We summarize the effects of plasma on eukaryotic cells, especially on keratinocytes in terms of viability, proliferation, DNA, adhesion molecules and angiogenesis together with the role of reactive oxygen species and other components of plasma.

View Article: PubMed Central - PubMed

Affiliation: Department of Pharmaceutical Biology, Institute of Pharmacy, Ernst-Moritz-Arndt University of Greifswald, D17489 Greifswald, Germany.

ABSTRACT
Non-thermal atmospheric-pressure plasma, also named cold plasma, is defined as a partly ionized gas. Therefore, it cannot be equated with plasma from blood; it is not biological in nature. Non-thermal atmospheric-pressure plasma is a new innovative approach in medicine not only for the treatment of wounds, but with a wide-range of other applications, as e.g. topical treatment of other skin diseases with microbial involvement or treatment of cancer diseases. This review emphasizes plasma effects on wound healing. Non-thermal atmospheric-pressure plasma can support wound healing by its antiseptic effects, by stimulation of proliferation and migration of wound relating skin cells, by activation or inhibition of integrin receptors on the cell surface or by its pro-angiogenic effect. We summarize the effects of plasma on eukaryotic cells, especially on keratinocytes in terms of viability, proliferation, DNA, adhesion molecules and angiogenesis together with the role of reactive oxygen species and other components of plasma. The outcome of first clinical trials regarding wound healing is pointed out.

No MeSH data available.


Related in: MedlinePlus

Composition of non-thermal atmospheric-pressure plasmas.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
getmorefigures.php?uid=PMC4256026&req=5

f1-bt-22-477: Composition of non-thermal atmospheric-pressure plasmas.

Mentions: Physical plasma has been considered as the fourth state of matter and is defined as a completely or partly ionized gas. Irvine Langmuir (1928) was the first who named ionized gas “plasma”. In plasmas electrons, positive and negative ions, neutral atoms, and neutral or charged molecules can be identified. It is further characterized by its temperature, different types of radiation (e.g. UVB), and by electric fields (Fig. 1). Plasmas can be seen in daily life, e.g. as lightning in thunderstorms, northern lights, neon lights or plasma displays.


Non-thermal atmospheric-pressure plasma possible application in wound healing.

Haertel B, von Woedtke T, Weltmann KD, Lindequist U - Biomol Ther (Seoul) (2014)

Composition of non-thermal atmospheric-pressure plasmas.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4256026&req=5

f1-bt-22-477: Composition of non-thermal atmospheric-pressure plasmas.
Mentions: Physical plasma has been considered as the fourth state of matter and is defined as a completely or partly ionized gas. Irvine Langmuir (1928) was the first who named ionized gas “plasma”. In plasmas electrons, positive and negative ions, neutral atoms, and neutral or charged molecules can be identified. It is further characterized by its temperature, different types of radiation (e.g. UVB), and by electric fields (Fig. 1). Plasmas can be seen in daily life, e.g. as lightning in thunderstorms, northern lights, neon lights or plasma displays.

Bottom Line: Therefore, it cannot be equated with plasma from blood; it is not biological in nature.This review emphasizes plasma effects on wound healing.We summarize the effects of plasma on eukaryotic cells, especially on keratinocytes in terms of viability, proliferation, DNA, adhesion molecules and angiogenesis together with the role of reactive oxygen species and other components of plasma.

View Article: PubMed Central - PubMed

Affiliation: Department of Pharmaceutical Biology, Institute of Pharmacy, Ernst-Moritz-Arndt University of Greifswald, D17489 Greifswald, Germany.

ABSTRACT
Non-thermal atmospheric-pressure plasma, also named cold plasma, is defined as a partly ionized gas. Therefore, it cannot be equated with plasma from blood; it is not biological in nature. Non-thermal atmospheric-pressure plasma is a new innovative approach in medicine not only for the treatment of wounds, but with a wide-range of other applications, as e.g. topical treatment of other skin diseases with microbial involvement or treatment of cancer diseases. This review emphasizes plasma effects on wound healing. Non-thermal atmospheric-pressure plasma can support wound healing by its antiseptic effects, by stimulation of proliferation and migration of wound relating skin cells, by activation or inhibition of integrin receptors on the cell surface or by its pro-angiogenic effect. We summarize the effects of plasma on eukaryotic cells, especially on keratinocytes in terms of viability, proliferation, DNA, adhesion molecules and angiogenesis together with the role of reactive oxygen species and other components of plasma. The outcome of first clinical trials regarding wound healing is pointed out.

No MeSH data available.


Related in: MedlinePlus