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Effects of a Rivastigmine Patch on Self-Care Activities in Patients with Alzheimer's Disease plus Cerebrovascular Disease.

Kim YK, Lim KB, Lee SC, Park JW, Lee HJ, Kwon BS, Lee HJ - Dement Geriatr Cogn Dis Extra (2014)

Bottom Line: Patients showed a mean improvement of 21.9 points, as compared with the baseline K-MBI score of 30.3 (p < 0.05).Significantly better outcomes were seen in secondary outcome variables, for example the K-MMSE and backward digit span.The most frequent adverse events were skin problems, such as itching sensation (10%).

View Article: PubMed Central - PubMed

Affiliation: Department of Physical Medicine and Rehabilitation, Myongji Hospital, Kwandong University College of Medicine, Goyang, South Korea.

ABSTRACT

Background/aims: In dementia patients, a deficit in activities of daily living (ADL) is one of the main problems. Our objective was to assess ADL using the Korean Modified Barthel Index (K-MBI) in patients with Alzheimer's disease (AD) plus cerebrovascular disease (CVD) treated with a rivastigmine patch for 24 weeks in an open-label, observational study.

Methods: 29 patients were enrolled who met the National Institute of Neurological and Communicative Disorders and Stroke/Alzheimer's Disease and Related Disorders Association (NINCDS/ ANDRA) criteria and had a score of 10-26 on the Korean version of the Mini-Mental State Examination (K-MMSE). After the rivastigmine patch had been applied for 24 weeks, changes in self-care activities were assessed using the K-MBI.

Results: The average age of the patients was 62.8 years, and they had an average K-MMSE score of 16.2. Patients showed a mean improvement of 21.9 points, as compared with the baseline K-MBI score of 30.3 (p < 0.05). Significantly better outcomes were seen in secondary outcome variables, for example the K-MMSE and backward digit span. The most frequent adverse events were skin problems, such as itching sensation (10%).

Conclusion: In this multicenter, open-label, observational study, the rivastigmine patch was associated with improvements in ADL in patients with AD plus CVD.

No MeSH data available.


Related in: MedlinePlus

K-MMSE. The baseline average K-MMSE score was 16.2. A mean improvement of 3.7 was observed as compared with the baseline MMSE score (* p < 0.05).
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Figure 2: K-MMSE. The baseline average K-MMSE score was 16.2. A mean improvement of 3.7 was observed as compared with the baseline MMSE score (* p < 0.05).

Mentions: Significantly better outcomes were seen in secondary efficacy variables, for example, the K-MMSE and the backward digit span in the Seoul Neuropsychological Screening Battery. The mean K-MMSE score increased by 3.7 points (p < 0.05) (fig. 2). In the backward digit span test, the mean improvement was 0.9 points (p < 0.05) (fig. 3).


Effects of a Rivastigmine Patch on Self-Care Activities in Patients with Alzheimer's Disease plus Cerebrovascular Disease.

Kim YK, Lim KB, Lee SC, Park JW, Lee HJ, Kwon BS, Lee HJ - Dement Geriatr Cogn Dis Extra (2014)

K-MMSE. The baseline average K-MMSE score was 16.2. A mean improvement of 3.7 was observed as compared with the baseline MMSE score (* p < 0.05).
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4255993&req=5

Figure 2: K-MMSE. The baseline average K-MMSE score was 16.2. A mean improvement of 3.7 was observed as compared with the baseline MMSE score (* p < 0.05).
Mentions: Significantly better outcomes were seen in secondary efficacy variables, for example, the K-MMSE and the backward digit span in the Seoul Neuropsychological Screening Battery. The mean K-MMSE score increased by 3.7 points (p < 0.05) (fig. 2). In the backward digit span test, the mean improvement was 0.9 points (p < 0.05) (fig. 3).

Bottom Line: Patients showed a mean improvement of 21.9 points, as compared with the baseline K-MBI score of 30.3 (p < 0.05).Significantly better outcomes were seen in secondary outcome variables, for example the K-MMSE and backward digit span.The most frequent adverse events were skin problems, such as itching sensation (10%).

View Article: PubMed Central - PubMed

Affiliation: Department of Physical Medicine and Rehabilitation, Myongji Hospital, Kwandong University College of Medicine, Goyang, South Korea.

ABSTRACT

Background/aims: In dementia patients, a deficit in activities of daily living (ADL) is one of the main problems. Our objective was to assess ADL using the Korean Modified Barthel Index (K-MBI) in patients with Alzheimer's disease (AD) plus cerebrovascular disease (CVD) treated with a rivastigmine patch for 24 weeks in an open-label, observational study.

Methods: 29 patients were enrolled who met the National Institute of Neurological and Communicative Disorders and Stroke/Alzheimer's Disease and Related Disorders Association (NINCDS/ ANDRA) criteria and had a score of 10-26 on the Korean version of the Mini-Mental State Examination (K-MMSE). After the rivastigmine patch had been applied for 24 weeks, changes in self-care activities were assessed using the K-MBI.

Results: The average age of the patients was 62.8 years, and they had an average K-MMSE score of 16.2. Patients showed a mean improvement of 21.9 points, as compared with the baseline K-MBI score of 30.3 (p < 0.05). Significantly better outcomes were seen in secondary outcome variables, for example the K-MMSE and backward digit span. The most frequent adverse events were skin problems, such as itching sensation (10%).

Conclusion: In this multicenter, open-label, observational study, the rivastigmine patch was associated with improvements in ADL in patients with AD plus CVD.

No MeSH data available.


Related in: MedlinePlus