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Effects of a Rivastigmine Patch on Self-Care Activities in Patients with Alzheimer's Disease plus Cerebrovascular Disease.

Kim YK, Lim KB, Lee SC, Park JW, Lee HJ, Kwon BS, Lee HJ - Dement Geriatr Cogn Dis Extra (2014)

Bottom Line: Patients showed a mean improvement of 21.9 points, as compared with the baseline K-MBI score of 30.3 (p < 0.05).Significantly better outcomes were seen in secondary outcome variables, for example the K-MMSE and backward digit span.The most frequent adverse events were skin problems, such as itching sensation (10%).

View Article: PubMed Central - PubMed

Affiliation: Department of Physical Medicine and Rehabilitation, Myongji Hospital, Kwandong University College of Medicine, Goyang, South Korea.

ABSTRACT

Background/aims: In dementia patients, a deficit in activities of daily living (ADL) is one of the main problems. Our objective was to assess ADL using the Korean Modified Barthel Index (K-MBI) in patients with Alzheimer's disease (AD) plus cerebrovascular disease (CVD) treated with a rivastigmine patch for 24 weeks in an open-label, observational study.

Methods: 29 patients were enrolled who met the National Institute of Neurological and Communicative Disorders and Stroke/Alzheimer's Disease and Related Disorders Association (NINCDS/ ANDRA) criteria and had a score of 10-26 on the Korean version of the Mini-Mental State Examination (K-MMSE). After the rivastigmine patch had been applied for 24 weeks, changes in self-care activities were assessed using the K-MBI.

Results: The average age of the patients was 62.8 years, and they had an average K-MMSE score of 16.2. Patients showed a mean improvement of 21.9 points, as compared with the baseline K-MBI score of 30.3 (p < 0.05). Significantly better outcomes were seen in secondary outcome variables, for example the K-MMSE and backward digit span. The most frequent adverse events were skin problems, such as itching sensation (10%).

Conclusion: In this multicenter, open-label, observational study, the rivastigmine patch was associated with improvements in ADL in patients with AD plus CVD.

No MeSH data available.


Related in: MedlinePlus

a K-MBI. The baseline average K-MBI score was 30.3. A mean improvement of 21.9 was observed as compared with the baseline K-MBI score (* p < 0.05). b Subscales of the K-MBI. There was a moderate improvement in several subscale scores of the K-MBI, such as feeding, dressing, toileting, transfer, gait, bladder control and bowel control.
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Figure 1: a K-MBI. The baseline average K-MBI score was 30.3. A mean improvement of 21.9 was observed as compared with the baseline K-MBI score (* p < 0.05). b Subscales of the K-MBI. There was a moderate improvement in several subscale scores of the K-MBI, such as feeding, dressing, toileting, transfer, gait, bladder control and bowel control.

Mentions: A primary efficacy variable was the mean change in the K-MBI score at 24 weeks, compared with the baseline score, in patients with AD plus CVD. Patients treated with a rivastigmine patch showed a mean improvement of 21.9 points (p < 0.05) (fig. 1a). On the subscale analysis of self-care activities, improvements were observed especially in eating, toileting, dressing, transfer, gait, bladder control, and bowel control (fig. 1b).


Effects of a Rivastigmine Patch on Self-Care Activities in Patients with Alzheimer's Disease plus Cerebrovascular Disease.

Kim YK, Lim KB, Lee SC, Park JW, Lee HJ, Kwon BS, Lee HJ - Dement Geriatr Cogn Dis Extra (2014)

a K-MBI. The baseline average K-MBI score was 30.3. A mean improvement of 21.9 was observed as compared with the baseline K-MBI score (* p < 0.05). b Subscales of the K-MBI. There was a moderate improvement in several subscale scores of the K-MBI, such as feeding, dressing, toileting, transfer, gait, bladder control and bowel control.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4255993&req=5

Figure 1: a K-MBI. The baseline average K-MBI score was 30.3. A mean improvement of 21.9 was observed as compared with the baseline K-MBI score (* p < 0.05). b Subscales of the K-MBI. There was a moderate improvement in several subscale scores of the K-MBI, such as feeding, dressing, toileting, transfer, gait, bladder control and bowel control.
Mentions: A primary efficacy variable was the mean change in the K-MBI score at 24 weeks, compared with the baseline score, in patients with AD plus CVD. Patients treated with a rivastigmine patch showed a mean improvement of 21.9 points (p < 0.05) (fig. 1a). On the subscale analysis of self-care activities, improvements were observed especially in eating, toileting, dressing, transfer, gait, bladder control, and bowel control (fig. 1b).

Bottom Line: Patients showed a mean improvement of 21.9 points, as compared with the baseline K-MBI score of 30.3 (p < 0.05).Significantly better outcomes were seen in secondary outcome variables, for example the K-MMSE and backward digit span.The most frequent adverse events were skin problems, such as itching sensation (10%).

View Article: PubMed Central - PubMed

Affiliation: Department of Physical Medicine and Rehabilitation, Myongji Hospital, Kwandong University College of Medicine, Goyang, South Korea.

ABSTRACT

Background/aims: In dementia patients, a deficit in activities of daily living (ADL) is one of the main problems. Our objective was to assess ADL using the Korean Modified Barthel Index (K-MBI) in patients with Alzheimer's disease (AD) plus cerebrovascular disease (CVD) treated with a rivastigmine patch for 24 weeks in an open-label, observational study.

Methods: 29 patients were enrolled who met the National Institute of Neurological and Communicative Disorders and Stroke/Alzheimer's Disease and Related Disorders Association (NINCDS/ ANDRA) criteria and had a score of 10-26 on the Korean version of the Mini-Mental State Examination (K-MMSE). After the rivastigmine patch had been applied for 24 weeks, changes in self-care activities were assessed using the K-MBI.

Results: The average age of the patients was 62.8 years, and they had an average K-MMSE score of 16.2. Patients showed a mean improvement of 21.9 points, as compared with the baseline K-MBI score of 30.3 (p < 0.05). Significantly better outcomes were seen in secondary outcome variables, for example the K-MMSE and backward digit span. The most frequent adverse events were skin problems, such as itching sensation (10%).

Conclusion: In this multicenter, open-label, observational study, the rivastigmine patch was associated with improvements in ADL in patients with AD plus CVD.

No MeSH data available.


Related in: MedlinePlus