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Glutathione S-transferase gene GSTM1, gene-gene interaction, and gastric cancer susceptibility: evidence from an updated meta-analysis.

Lao X, Peng Q, Lu Y, Li S, Qin X, Chen Z, Chen J - Cancer Cell Int. (2014)

Bottom Line: Thus, a meta-analysis was performed.We identified 54 individual studies involving 9,322 cases and 15,118 controls through computer-based searches of PubMed, Embase, and Cochrane Library.From stratification analyses for ethnicity, alcohol drinking, Helicobacter pylori infection, an effect modification of gastric cancer risk was found in the subgroups of ethnicity, smoking status, Helicobacter pylori infection, whereas result was found in the subgroups of alcohol drinking.

View Article: PubMed Central - PubMed

Affiliation: Department of Clinical Laboratory, First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi Zhuang Autonomous Region China.

ABSTRACT

Background: The genotype of GSTM1 have been implicated in gastric cancer risk, but numerous individual studies showed mixed, or even conflicting results. Thus, a meta-analysis was performed.

Results: We identified 54 individual studies involving 9,322 cases and 15,118 controls through computer-based searches of PubMed, Embase, and Cochrane Library. It was found that the genotype of GSTM1 was associated with an increased gastric cancer risk (OR = 1.207, 95% CI: 1.106-1.317, P < 0.001), under the random-effects model (I(2) : 49.9%, PQ <0.001). From stratification analyses for ethnicity, alcohol drinking, Helicobacter pylori infection, an effect modification of gastric cancer risk was found in the subgroups of ethnicity, smoking status, Helicobacter pylori infection, whereas result was found in the subgroups of alcohol drinking. We also undertook gene-gene interaction analysis between GSTM1 and GSTT1 genes for gastric cancer risk, and the results indicated that the dual genotypes of GSTM1 and GSTT1 might elevate the risk of gastric cancer (OR = 1.505, 95% CI: 1.165-1.944, P = 002).

Conclusions: This meta-analysis suggests that the genotype of GSTM1 may be a important genetic risk factor for gastric cancer development.

No MeSH data available.


Related in: MedlinePlus

Begg’s funnel plots for publication bias of the  genotype of GSTM1 and gastric cancer risk in the overall populations ( genotype vs. present genotype). Each point represents a separate study for the indicated association.
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Fig3: Begg’s funnel plots for publication bias of the genotype of GSTM1 and gastric cancer risk in the overall populations ( genotype vs. present genotype). Each point represents a separate study for the indicated association.

Mentions: Begg’s funnel plot and Egger’s test were performed to access the publication bias of literatures. As shown in Figure 3, the shape of the funnel plots seemed asymmetrical suggesting the presence of publication bias. Then, the Egger’s test was adopted to provide statistical evidence of funnel plot asymmetry. As expected, the results have shown that publication bias was evident in this meta-analysis (P = 0.004). Hence, the non-parametric “trim and fill” method [71], suggested by the Duval and Tweedie, was used to adjust for it. Meta-analysis with and without “trim and fill” method did not draw different conclusion (data not shown), indicating that our results were statistically robust.Figure 3


Glutathione S-transferase gene GSTM1, gene-gene interaction, and gastric cancer susceptibility: evidence from an updated meta-analysis.

Lao X, Peng Q, Lu Y, Li S, Qin X, Chen Z, Chen J - Cancer Cell Int. (2014)

Begg’s funnel plots for publication bias of the  genotype of GSTM1 and gastric cancer risk in the overall populations ( genotype vs. present genotype). Each point represents a separate study for the indicated association.
© Copyright Policy - open-access
Related In: Results  -  Collection

License 1 - License 2
Show All Figures
getmorefigures.php?uid=PMC4255933&req=5

Fig3: Begg’s funnel plots for publication bias of the genotype of GSTM1 and gastric cancer risk in the overall populations ( genotype vs. present genotype). Each point represents a separate study for the indicated association.
Mentions: Begg’s funnel plot and Egger’s test were performed to access the publication bias of literatures. As shown in Figure 3, the shape of the funnel plots seemed asymmetrical suggesting the presence of publication bias. Then, the Egger’s test was adopted to provide statistical evidence of funnel plot asymmetry. As expected, the results have shown that publication bias was evident in this meta-analysis (P = 0.004). Hence, the non-parametric “trim and fill” method [71], suggested by the Duval and Tweedie, was used to adjust for it. Meta-analysis with and without “trim and fill” method did not draw different conclusion (data not shown), indicating that our results were statistically robust.Figure 3

Bottom Line: Thus, a meta-analysis was performed.We identified 54 individual studies involving 9,322 cases and 15,118 controls through computer-based searches of PubMed, Embase, and Cochrane Library.From stratification analyses for ethnicity, alcohol drinking, Helicobacter pylori infection, an effect modification of gastric cancer risk was found in the subgroups of ethnicity, smoking status, Helicobacter pylori infection, whereas result was found in the subgroups of alcohol drinking.

View Article: PubMed Central - PubMed

Affiliation: Department of Clinical Laboratory, First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi Zhuang Autonomous Region China.

ABSTRACT

Background: The genotype of GSTM1 have been implicated in gastric cancer risk, but numerous individual studies showed mixed, or even conflicting results. Thus, a meta-analysis was performed.

Results: We identified 54 individual studies involving 9,322 cases and 15,118 controls through computer-based searches of PubMed, Embase, and Cochrane Library. It was found that the genotype of GSTM1 was associated with an increased gastric cancer risk (OR = 1.207, 95% CI: 1.106-1.317, P < 0.001), under the random-effects model (I(2) : 49.9%, PQ <0.001). From stratification analyses for ethnicity, alcohol drinking, Helicobacter pylori infection, an effect modification of gastric cancer risk was found in the subgroups of ethnicity, smoking status, Helicobacter pylori infection, whereas result was found in the subgroups of alcohol drinking. We also undertook gene-gene interaction analysis between GSTM1 and GSTT1 genes for gastric cancer risk, and the results indicated that the dual genotypes of GSTM1 and GSTT1 might elevate the risk of gastric cancer (OR = 1.505, 95% CI: 1.165-1.944, P = 002).

Conclusions: This meta-analysis suggests that the genotype of GSTM1 may be a important genetic risk factor for gastric cancer development.

No MeSH data available.


Related in: MedlinePlus