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Glutathione S-transferase gene GSTM1, gene-gene interaction, and gastric cancer susceptibility: evidence from an updated meta-analysis.

Lao X, Peng Q, Lu Y, Li S, Qin X, Chen Z, Chen J - Cancer Cell Int. (2014)

Bottom Line: Thus, a meta-analysis was performed.We identified 54 individual studies involving 9,322 cases and 15,118 controls through computer-based searches of PubMed, Embase, and Cochrane Library.From stratification analyses for ethnicity, alcohol drinking, Helicobacter pylori infection, an effect modification of gastric cancer risk was found in the subgroups of ethnicity, smoking status, Helicobacter pylori infection, whereas result was found in the subgroups of alcohol drinking.

View Article: PubMed Central - PubMed

Affiliation: Department of Clinical Laboratory, First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi Zhuang Autonomous Region China.

ABSTRACT

Background: The genotype of GSTM1 have been implicated in gastric cancer risk, but numerous individual studies showed mixed, or even conflicting results. Thus, a meta-analysis was performed.

Results: We identified 54 individual studies involving 9,322 cases and 15,118 controls through computer-based searches of PubMed, Embase, and Cochrane Library. It was found that the genotype of GSTM1 was associated with an increased gastric cancer risk (OR = 1.207, 95% CI: 1.106-1.317, P < 0.001), under the random-effects model (I(2) : 49.9%, PQ <0.001). From stratification analyses for ethnicity, alcohol drinking, Helicobacter pylori infection, an effect modification of gastric cancer risk was found in the subgroups of ethnicity, smoking status, Helicobacter pylori infection, whereas result was found in the subgroups of alcohol drinking. We also undertook gene-gene interaction analysis between GSTM1 and GSTT1 genes for gastric cancer risk, and the results indicated that the dual genotypes of GSTM1 and GSTT1 might elevate the risk of gastric cancer (OR = 1.505, 95% CI: 1.165-1.944, P = 002).

Conclusions: This meta-analysis suggests that the genotype of GSTM1 may be a important genetic risk factor for gastric cancer development.

No MeSH data available.


Related in: MedlinePlus

Forest plots for the  genotype of GSTM1 and gastric cancer risk of overall populations using a random-effects model ( genotype vs. present genotype).
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Fig2: Forest plots for the genotype of GSTM1 and gastric cancer risk of overall populations using a random-effects model ( genotype vs. present genotype).

Mentions: The results of pooling all studies showed that the genotype of GSTM1 was associated with an increased gastric cancer risk (OR = 1.207, 95% CI: 1.106-1.317, P < 0.001), using the random-effects model (I2 : 49.9%, PQ < 0.001) (Figure 2). As shown in Tables 2, specific data were stratified, on the basis of ethnicity, into three subgroups: Aians, Caucasians and Negroids. Statistically significant findings were found in Asians and Caucasians but not in Negroids. The pooled OR were 1.264 (95% CI: 1.164-1.422, P < 0.001, P for heterogeneity = 0.002) in Aians, 1.154 (95% CI: 1.008-1.321, P < 0.037, P for heterogeneity = 0.001) in Caucasians, and 1.182 (95% CI: 0.142-9.827, P < 0.887) in Negroids, respectively.Figure 2


Glutathione S-transferase gene GSTM1, gene-gene interaction, and gastric cancer susceptibility: evidence from an updated meta-analysis.

Lao X, Peng Q, Lu Y, Li S, Qin X, Chen Z, Chen J - Cancer Cell Int. (2014)

Forest plots for the  genotype of GSTM1 and gastric cancer risk of overall populations using a random-effects model ( genotype vs. present genotype).
© Copyright Policy - open-access
Related In: Results  -  Collection

License 1 - License 2
Show All Figures
getmorefigures.php?uid=PMC4255933&req=5

Fig2: Forest plots for the genotype of GSTM1 and gastric cancer risk of overall populations using a random-effects model ( genotype vs. present genotype).
Mentions: The results of pooling all studies showed that the genotype of GSTM1 was associated with an increased gastric cancer risk (OR = 1.207, 95% CI: 1.106-1.317, P < 0.001), using the random-effects model (I2 : 49.9%, PQ < 0.001) (Figure 2). As shown in Tables 2, specific data were stratified, on the basis of ethnicity, into three subgroups: Aians, Caucasians and Negroids. Statistically significant findings were found in Asians and Caucasians but not in Negroids. The pooled OR were 1.264 (95% CI: 1.164-1.422, P < 0.001, P for heterogeneity = 0.002) in Aians, 1.154 (95% CI: 1.008-1.321, P < 0.037, P for heterogeneity = 0.001) in Caucasians, and 1.182 (95% CI: 0.142-9.827, P < 0.887) in Negroids, respectively.Figure 2

Bottom Line: Thus, a meta-analysis was performed.We identified 54 individual studies involving 9,322 cases and 15,118 controls through computer-based searches of PubMed, Embase, and Cochrane Library.From stratification analyses for ethnicity, alcohol drinking, Helicobacter pylori infection, an effect modification of gastric cancer risk was found in the subgroups of ethnicity, smoking status, Helicobacter pylori infection, whereas result was found in the subgroups of alcohol drinking.

View Article: PubMed Central - PubMed

Affiliation: Department of Clinical Laboratory, First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi Zhuang Autonomous Region China.

ABSTRACT

Background: The genotype of GSTM1 have been implicated in gastric cancer risk, but numerous individual studies showed mixed, or even conflicting results. Thus, a meta-analysis was performed.

Results: We identified 54 individual studies involving 9,322 cases and 15,118 controls through computer-based searches of PubMed, Embase, and Cochrane Library. It was found that the genotype of GSTM1 was associated with an increased gastric cancer risk (OR = 1.207, 95% CI: 1.106-1.317, P < 0.001), under the random-effects model (I(2) : 49.9%, PQ <0.001). From stratification analyses for ethnicity, alcohol drinking, Helicobacter pylori infection, an effect modification of gastric cancer risk was found in the subgroups of ethnicity, smoking status, Helicobacter pylori infection, whereas result was found in the subgroups of alcohol drinking. We also undertook gene-gene interaction analysis between GSTM1 and GSTT1 genes for gastric cancer risk, and the results indicated that the dual genotypes of GSTM1 and GSTT1 might elevate the risk of gastric cancer (OR = 1.505, 95% CI: 1.165-1.944, P = 002).

Conclusions: This meta-analysis suggests that the genotype of GSTM1 may be a important genetic risk factor for gastric cancer development.

No MeSH data available.


Related in: MedlinePlus