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Glutathione S-transferase gene GSTM1, gene-gene interaction, and gastric cancer susceptibility: evidence from an updated meta-analysis.

Lao X, Peng Q, Lu Y, Li S, Qin X, Chen Z, Chen J - Cancer Cell Int. (2014)

Bottom Line: Thus, a meta-analysis was performed.We identified 54 individual studies involving 9,322 cases and 15,118 controls through computer-based searches of PubMed, Embase, and Cochrane Library.From stratification analyses for ethnicity, alcohol drinking, Helicobacter pylori infection, an effect modification of gastric cancer risk was found in the subgroups of ethnicity, smoking status, Helicobacter pylori infection, whereas result was found in the subgroups of alcohol drinking.

View Article: PubMed Central - PubMed

Affiliation: Department of Clinical Laboratory, First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi Zhuang Autonomous Region China.

ABSTRACT

Background: The genotype of GSTM1 have been implicated in gastric cancer risk, but numerous individual studies showed mixed, or even conflicting results. Thus, a meta-analysis was performed.

Results: We identified 54 individual studies involving 9,322 cases and 15,118 controls through computer-based searches of PubMed, Embase, and Cochrane Library. It was found that the genotype of GSTM1 was associated with an increased gastric cancer risk (OR = 1.207, 95% CI: 1.106-1.317, P < 0.001), under the random-effects model (I(2) : 49.9%, PQ <0.001). From stratification analyses for ethnicity, alcohol drinking, Helicobacter pylori infection, an effect modification of gastric cancer risk was found in the subgroups of ethnicity, smoking status, Helicobacter pylori infection, whereas result was found in the subgroups of alcohol drinking. We also undertook gene-gene interaction analysis between GSTM1 and GSTT1 genes for gastric cancer risk, and the results indicated that the dual genotypes of GSTM1 and GSTT1 might elevate the risk of gastric cancer (OR = 1.505, 95% CI: 1.165-1.944, P = 002).

Conclusions: This meta-analysis suggests that the genotype of GSTM1 may be a important genetic risk factor for gastric cancer development.

No MeSH data available.


Related in: MedlinePlus

Flowchart of the selection of studies for inclusion in the meta-analysis.
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Fig1: Flowchart of the selection of studies for inclusion in the meta-analysis.

Mentions: After comprehensive searching, a total of 202 articles were retrieved, but only 49 full-text publications [15-21,23-27,29-65] which catered to the inclusion criteria were finally included in our meta-analysis. Additonal four studies [13,14,22,28] were identified by reviewing the bibliographies of the retrieved articles (Figure 1). Besides, because there was a study [29] containing two different ethnic populations (Caucasians and Negroids), we treat it as two individual case–control studies. Thus, in our meta-analysis we initially included a total of 54 studies which assessed the associations between GSTM1 polymorphism and gastric cancer. The 54 studies were published from 1991 to 2013 with 35 were carried out in Asian countries, 11 in Europe countries, and eight in America. Of these 54 studies, 51 were case–control design, while the other three were nested case–control design from cohort. The number of cases in the included studies for GSTM1 deletion varied from 5 to 1225 patients. There were 14 studies focused on the joint effect of GSTM1 genotype and smoking status on gastric cancer risk, four investigated the joint effect of GSTM1 genotype and alcohol drinking, and seven eveluated the joint effect of GSTM1 genotype and Helicobacter pylori infection. 15 studies investigated the gene-gene interaction between GSTM1 and GSTT1 polymorphisms in the association with gastric cancer risk. Table 1 presents a brief description of these 54 studies.Figure 1


Glutathione S-transferase gene GSTM1, gene-gene interaction, and gastric cancer susceptibility: evidence from an updated meta-analysis.

Lao X, Peng Q, Lu Y, Li S, Qin X, Chen Z, Chen J - Cancer Cell Int. (2014)

Flowchart of the selection of studies for inclusion in the meta-analysis.
© Copyright Policy - open-access
Related In: Results  -  Collection

License 1 - License 2
Show All Figures
getmorefigures.php?uid=PMC4255933&req=5

Fig1: Flowchart of the selection of studies for inclusion in the meta-analysis.
Mentions: After comprehensive searching, a total of 202 articles were retrieved, but only 49 full-text publications [15-21,23-27,29-65] which catered to the inclusion criteria were finally included in our meta-analysis. Additonal four studies [13,14,22,28] were identified by reviewing the bibliographies of the retrieved articles (Figure 1). Besides, because there was a study [29] containing two different ethnic populations (Caucasians and Negroids), we treat it as two individual case–control studies. Thus, in our meta-analysis we initially included a total of 54 studies which assessed the associations between GSTM1 polymorphism and gastric cancer. The 54 studies were published from 1991 to 2013 with 35 were carried out in Asian countries, 11 in Europe countries, and eight in America. Of these 54 studies, 51 were case–control design, while the other three were nested case–control design from cohort. The number of cases in the included studies for GSTM1 deletion varied from 5 to 1225 patients. There were 14 studies focused on the joint effect of GSTM1 genotype and smoking status on gastric cancer risk, four investigated the joint effect of GSTM1 genotype and alcohol drinking, and seven eveluated the joint effect of GSTM1 genotype and Helicobacter pylori infection. 15 studies investigated the gene-gene interaction between GSTM1 and GSTT1 polymorphisms in the association with gastric cancer risk. Table 1 presents a brief description of these 54 studies.Figure 1

Bottom Line: Thus, a meta-analysis was performed.We identified 54 individual studies involving 9,322 cases and 15,118 controls through computer-based searches of PubMed, Embase, and Cochrane Library.From stratification analyses for ethnicity, alcohol drinking, Helicobacter pylori infection, an effect modification of gastric cancer risk was found in the subgroups of ethnicity, smoking status, Helicobacter pylori infection, whereas result was found in the subgroups of alcohol drinking.

View Article: PubMed Central - PubMed

Affiliation: Department of Clinical Laboratory, First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi Zhuang Autonomous Region China.

ABSTRACT

Background: The genotype of GSTM1 have been implicated in gastric cancer risk, but numerous individual studies showed mixed, or even conflicting results. Thus, a meta-analysis was performed.

Results: We identified 54 individual studies involving 9,322 cases and 15,118 controls through computer-based searches of PubMed, Embase, and Cochrane Library. It was found that the genotype of GSTM1 was associated with an increased gastric cancer risk (OR = 1.207, 95% CI: 1.106-1.317, P < 0.001), under the random-effects model (I(2) : 49.9%, PQ <0.001). From stratification analyses for ethnicity, alcohol drinking, Helicobacter pylori infection, an effect modification of gastric cancer risk was found in the subgroups of ethnicity, smoking status, Helicobacter pylori infection, whereas result was found in the subgroups of alcohol drinking. We also undertook gene-gene interaction analysis between GSTM1 and GSTT1 genes for gastric cancer risk, and the results indicated that the dual genotypes of GSTM1 and GSTT1 might elevate the risk of gastric cancer (OR = 1.505, 95% CI: 1.165-1.944, P = 002).

Conclusions: This meta-analysis suggests that the genotype of GSTM1 may be a important genetic risk factor for gastric cancer development.

No MeSH data available.


Related in: MedlinePlus