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Simulation environment and graphical visualization environment: a COPD use-case.

Huertas-Migueláñez M, Mora D, Cano I, Maier D, Gomez-Cabrero D, Lluch-Ariet M, Miralles F - J Transl Med (2014)

Bottom Line: The data warehouse manager is responsible for managing the stored information and supporting its flow among the different modules.It has been proved that the simulation environment presented here allows the user to research and study the internal mechanisms of the human physiology by the use of models via a graphical visualization environment.A new tool for bio-researchers is ready for deployment in various use cases scenarios.

View Article: PubMed Central - HTML - PubMed

ABSTRACT

Background: Today, many different tools are developed to execute and visualize physiological models that represent the human physiology. Most of these tools run models written in very specific programming languages which in turn simplify the communication among models. Nevertheless, not all of these tools are able to run models written in different programming languages. In addition, interoperability between such models remains an unresolved issue.

Results: In this paper we present a simulation environment that allows, first, the execution of models developed in different programming languages and second the communication of parameters to interconnect these models. This simulation environment, developed within the Synergy-COPD project, aims at helping and supporting bio-researchers and medical students understand the internal mechanisms of the human body through the use of physiological models. This tool is composed of a graphical visualization environment, which is a web interface through which the user can interact with the models, and a simulation workflow management system composed of a control module and a data warehouse manager. The control module monitors the correct functioning of the whole system. The data warehouse manager is responsible for managing the stored information and supporting its flow among the different modules.

Conclusion: It has been proved that the simulation environment presented here allows the user to research and study the internal mechanisms of the human physiology by the use of models via a graphical visualization environment. A new tool for bio-researchers is ready for deployment in various use cases scenarios.

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On the left hand side of this image we can see that the user can choose up to three output variables of the model to be plotted. Our user has selected VO2 and PvO2. On the right hand side, we can see the graphical representation of these two output variables.
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Figure 8: On the left hand side of this image we can see that the user can choose up to three output variables of the model to be plotted. Our user has selected VO2 and PvO2. On the right hand side, we can see the graphical representation of these two output variables.

Mentions: A visual alert is presented when a simulation has finished. The results after model execution may be presented in tabular format (see Figure 7) or as a graphical plot (see Figure 8). The results may be downloaded in various formats including csv, spreadsheet and plain text format. The GVE also supports case storage and case management.


Simulation environment and graphical visualization environment: a COPD use-case.

Huertas-Migueláñez M, Mora D, Cano I, Maier D, Gomez-Cabrero D, Lluch-Ariet M, Miralles F - J Transl Med (2014)

On the left hand side of this image we can see that the user can choose up to three output variables of the model to be plotted. Our user has selected VO2 and PvO2. On the right hand side, we can see the graphical representation of these two output variables.
© Copyright Policy - open-access
Related In: Results  -  Collection

License 1 - License 2
Show All Figures
getmorefigures.php?uid=PMC4255913&req=5

Figure 8: On the left hand side of this image we can see that the user can choose up to three output variables of the model to be plotted. Our user has selected VO2 and PvO2. On the right hand side, we can see the graphical representation of these two output variables.
Mentions: A visual alert is presented when a simulation has finished. The results after model execution may be presented in tabular format (see Figure 7) or as a graphical plot (see Figure 8). The results may be downloaded in various formats including csv, spreadsheet and plain text format. The GVE also supports case storage and case management.

Bottom Line: The data warehouse manager is responsible for managing the stored information and supporting its flow among the different modules.It has been proved that the simulation environment presented here allows the user to research and study the internal mechanisms of the human physiology by the use of models via a graphical visualization environment.A new tool for bio-researchers is ready for deployment in various use cases scenarios.

View Article: PubMed Central - HTML - PubMed

ABSTRACT

Background: Today, many different tools are developed to execute and visualize physiological models that represent the human physiology. Most of these tools run models written in very specific programming languages which in turn simplify the communication among models. Nevertheless, not all of these tools are able to run models written in different programming languages. In addition, interoperability between such models remains an unresolved issue.

Results: In this paper we present a simulation environment that allows, first, the execution of models developed in different programming languages and second the communication of parameters to interconnect these models. This simulation environment, developed within the Synergy-COPD project, aims at helping and supporting bio-researchers and medical students understand the internal mechanisms of the human body through the use of physiological models. This tool is composed of a graphical visualization environment, which is a web interface through which the user can interact with the models, and a simulation workflow management system composed of a control module and a data warehouse manager. The control module monitors the correct functioning of the whole system. The data warehouse manager is responsible for managing the stored information and supporting its flow among the different modules.

Conclusion: It has been proved that the simulation environment presented here allows the user to research and study the internal mechanisms of the human physiology by the use of models via a graphical visualization environment. A new tool for bio-researchers is ready for deployment in various use cases scenarios.

Show MeSH