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Synergy-COPD: a systems approach for understanding and managing chronic diseases.

Gomez-Cabrero D, Lluch-Ariet M, Tegnér J, Cascante M, Miralles F, Roca J, Synergy-COPD consorti - J Transl Med (2014)

Bottom Line: The challenges posed by the epidemics of CD have triggered a novel health paradigm with major consequences on the traditional concept of disease and with a profound impact on key aspects of healthcare systems.The current manuscript describes main features of the project design and the strategies put in place for its development, as well the expected outcomes during the project life-span.Moreover, the manuscript serves as introductory and unifying chapter of the different papers associated to the Supplement describing the characteristics, tools and the objectives of Synergy-COPD.

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ABSTRACT
Chronic diseases (CD) are generating a dramatic societal burden worldwide that is expected to persist over the next decades. The challenges posed by the epidemics of CD have triggered a novel health paradigm with major consequences on the traditional concept of disease and with a profound impact on key aspects of healthcare systems. We hypothesized that the development of a systems approach to understand CD together with the generation of an ecosystem to transfer the acquired knowledge into the novel healthcare scenario may contribute to a cost-effective enhancement of health outcomes. To this end, we designed the Synergy-COPD project wherein the heterogeneity of chronic obstructive pulmonary disease (COPD) was addressed as a use case representative of CD. The current manuscript describes main features of the project design and the strategies put in place for its development, as well the expected outcomes during the project life-span. Moreover, the manuscript serves as introductory and unifying chapter of the different papers associated to the Supplement describing the characteristics, tools and the objectives of Synergy-COPD.

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The Synergy-COPD translational research design.
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Figure 1: The Synergy-COPD translational research design.

Mentions: This first chapter of the Supplement describes the aims, the overall design (Figure 1) and the different dimensions tackled in Synergy-COPD emphasizing its multidisciplinary nature. The entire Supplement has been conceived to reflect in detail the process of generation of the project and the complexities of its development. We hope that the different chapters will serve as a guide for other researchers aiming at generating novel biomedical knowledge using the potential of a systems approach, but also willing to transfer knowledge into innovative practices generating an iterative process between systems-oriented biomedical research and healthcare ultimately leading to enhanced cost-effective health outcomes. It is our purpose to drive the interested reader through the different papers associated to the Supplement aiming at providing insight into the different (but highly linked) aspects of the project and its outcomes. For these purposes, the Supplement is structured in four well-defined sections:


Synergy-COPD: a systems approach for understanding and managing chronic diseases.

Gomez-Cabrero D, Lluch-Ariet M, Tegnér J, Cascante M, Miralles F, Roca J, Synergy-COPD consorti - J Transl Med (2014)

The Synergy-COPD translational research design.
© Copyright Policy - open-access
Related In: Results  -  Collection

License 1 - License 2
Show All Figures
getmorefigures.php?uid=PMC4255903&req=5

Figure 1: The Synergy-COPD translational research design.
Mentions: This first chapter of the Supplement describes the aims, the overall design (Figure 1) and the different dimensions tackled in Synergy-COPD emphasizing its multidisciplinary nature. The entire Supplement has been conceived to reflect in detail the process of generation of the project and the complexities of its development. We hope that the different chapters will serve as a guide for other researchers aiming at generating novel biomedical knowledge using the potential of a systems approach, but also willing to transfer knowledge into innovative practices generating an iterative process between systems-oriented biomedical research and healthcare ultimately leading to enhanced cost-effective health outcomes. It is our purpose to drive the interested reader through the different papers associated to the Supplement aiming at providing insight into the different (but highly linked) aspects of the project and its outcomes. For these purposes, the Supplement is structured in four well-defined sections:

Bottom Line: The challenges posed by the epidemics of CD have triggered a novel health paradigm with major consequences on the traditional concept of disease and with a profound impact on key aspects of healthcare systems.The current manuscript describes main features of the project design and the strategies put in place for its development, as well the expected outcomes during the project life-span.Moreover, the manuscript serves as introductory and unifying chapter of the different papers associated to the Supplement describing the characteristics, tools and the objectives of Synergy-COPD.

View Article: PubMed Central - HTML - PubMed

ABSTRACT
Chronic diseases (CD) are generating a dramatic societal burden worldwide that is expected to persist over the next decades. The challenges posed by the epidemics of CD have triggered a novel health paradigm with major consequences on the traditional concept of disease and with a profound impact on key aspects of healthcare systems. We hypothesized that the development of a systems approach to understand CD together with the generation of an ecosystem to transfer the acquired knowledge into the novel healthcare scenario may contribute to a cost-effective enhancement of health outcomes. To this end, we designed the Synergy-COPD project wherein the heterogeneity of chronic obstructive pulmonary disease (COPD) was addressed as a use case representative of CD. The current manuscript describes main features of the project design and the strategies put in place for its development, as well the expected outcomes during the project life-span. Moreover, the manuscript serves as introductory and unifying chapter of the different papers associated to the Supplement describing the characteristics, tools and the objectives of Synergy-COPD.

Show MeSH
Related in: MedlinePlus