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Intracranial volume in 15 children with bilateral coronal craniosynostosis.

Tovetjärn RC, Maltese G, Wikberg E, Bernhardt P, Kölby L, Tarnow PE - Plast Reconstr Surg Glob Open (2014)

Bottom Line: Patients were compared with an age- and gender-matched control group of healthy children.The differences were not statistically significant (P > 0.05).Patients with BCS were operated on with spring-assisted cranioplasty seem to maintain their age-related ICV at 3 years of age when compared to normal children.

View Article: PubMed Central - PubMed

Affiliation: Craniofacial Unit, Department of Plastic Surgery, Institute of Clinical Sciences, Sahlgrenska Academy at the University of Gothenburg, Sahlgrenska University Hospital, Gothenburg, Sweden; and Department of Radiation Physics, Institute of Clinical Sciences, Sahlgrenska Academy at the University of Gothenburg, Sahlgrenska University Hospital, Gothenburg, Sweden.

ABSTRACT

Background: Intracranial volume (ICV) growth in patients with bilateral coronal craniosynostosis (BCS) is not well described. It is therefore important to evaluate the consequences of cranial surgery in children with this condition. The aim of the present study was to evaluate ICVs in patients operated on for BCS.

Methods: A consecutive series of patients with BCS were operated on using spring-assisted cranioplasty, with computed tomography scans in 0.6-mm slices, were included. A MATLAB-based computer program capable of measuring ICV was used. Patients were compared with an age- and gender-matched control group of healthy children. Student's t test was used for statistical analysis.

Results: Fifteen patients (7 girls and 8 boys) with 43 computed tomography scans were identified. The diagnoses were 13 syndromic BCS (3 Apert, 1 Crouzon, 6 Muenke, and 3 Saethre-Chotzen) and 2 nonsyndromic BCS. The mean preoperative volume at the age of 5 months (n = 15) was 887 mL (range, 687-1082). Mean volume at follow-up at the age of 3 years (n = 13) was 1369 mL (range, 1196-1616). In comparison, the mean ICVs for controls at the ages of 5 months (n = 30) and 3 years (n = 26) were 854 mL and 1358 mL, respectively. The differences were not statistically significant (P > 0.05).

Conclusions: Patients with BCS were operated on with spring-assisted cranioplasty seem to maintain their age-related ICV at 3 years of age when compared to normal children.

No MeSH data available.


Related in: MedlinePlus

Mean intracranial volume in patients preoperatively, postoperatively, and at 3-year follow-up compared with age- and gender-matched controls.
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Figure 3: Mean intracranial volume in patients preoperatively, postoperatively, and at 3-year follow-up compared with age- and gender-matched controls.

Mentions: In comparison, the mean ICV values for controls at the mean ages of 5 months (n = 30), 11 months (n = 30), and 3 years (n = 26) were 854 mL (SD, 137 mL), 1118 mL (SD, 117 mL), and 1358 mL (SD, 113 mL), respectively (Fig. 3). The current controls differed somewhat when compared to other published normative data12,13 (Table 2).


Intracranial volume in 15 children with bilateral coronal craniosynostosis.

Tovetjärn RC, Maltese G, Wikberg E, Bernhardt P, Kölby L, Tarnow PE - Plast Reconstr Surg Glob Open (2014)

Mean intracranial volume in patients preoperatively, postoperatively, and at 3-year follow-up compared with age- and gender-matched controls.
© Copyright Policy
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC4255886&req=5

Figure 3: Mean intracranial volume in patients preoperatively, postoperatively, and at 3-year follow-up compared with age- and gender-matched controls.
Mentions: In comparison, the mean ICV values for controls at the mean ages of 5 months (n = 30), 11 months (n = 30), and 3 years (n = 26) were 854 mL (SD, 137 mL), 1118 mL (SD, 117 mL), and 1358 mL (SD, 113 mL), respectively (Fig. 3). The current controls differed somewhat when compared to other published normative data12,13 (Table 2).

Bottom Line: Patients were compared with an age- and gender-matched control group of healthy children.The differences were not statistically significant (P > 0.05).Patients with BCS were operated on with spring-assisted cranioplasty seem to maintain their age-related ICV at 3 years of age when compared to normal children.

View Article: PubMed Central - PubMed

Affiliation: Craniofacial Unit, Department of Plastic Surgery, Institute of Clinical Sciences, Sahlgrenska Academy at the University of Gothenburg, Sahlgrenska University Hospital, Gothenburg, Sweden; and Department of Radiation Physics, Institute of Clinical Sciences, Sahlgrenska Academy at the University of Gothenburg, Sahlgrenska University Hospital, Gothenburg, Sweden.

ABSTRACT

Background: Intracranial volume (ICV) growth in patients with bilateral coronal craniosynostosis (BCS) is not well described. It is therefore important to evaluate the consequences of cranial surgery in children with this condition. The aim of the present study was to evaluate ICVs in patients operated on for BCS.

Methods: A consecutive series of patients with BCS were operated on using spring-assisted cranioplasty, with computed tomography scans in 0.6-mm slices, were included. A MATLAB-based computer program capable of measuring ICV was used. Patients were compared with an age- and gender-matched control group of healthy children. Student's t test was used for statistical analysis.

Results: Fifteen patients (7 girls and 8 boys) with 43 computed tomography scans were identified. The diagnoses were 13 syndromic BCS (3 Apert, 1 Crouzon, 6 Muenke, and 3 Saethre-Chotzen) and 2 nonsyndromic BCS. The mean preoperative volume at the age of 5 months (n = 15) was 887 mL (range, 687-1082). Mean volume at follow-up at the age of 3 years (n = 13) was 1369 mL (range, 1196-1616). In comparison, the mean ICVs for controls at the ages of 5 months (n = 30) and 3 years (n = 26) were 854 mL and 1358 mL, respectively. The differences were not statistically significant (P > 0.05).

Conclusions: Patients with BCS were operated on with spring-assisted cranioplasty seem to maintain their age-related ICV at 3 years of age when compared to normal children.

No MeSH data available.


Related in: MedlinePlus