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Biomedical research in a Digital Health Framework.

Cano I, Lluch-Ariet M, Gomez-Cabrero D, Maier D, Kalko S, Cascante M, Tegnér J, Miralles F, Herrera D, Roca J, Synergy-COPD consorti - J Transl Med (2014)

Bottom Line: This article describes a Digital Health Framework (DHF), benefitting from the lessons learnt during the three-year life span of the FP7 Synergy-COPD project.Finally, the specifics of the building blocks strategy for deployment of the DHF, as well as the steps toward adoption are analyzed.The proposed architectural solutions and implementation steps constitute a pivotal strategy to foster and enable 4P medicine (Predictive, Preventive, Personalized and Participatory) in practice and should provide a head start to any community and institution currently considering to implement a biomedical research platform.

View Article: PubMed Central - HTML - PubMed

ABSTRACT
This article describes a Digital Health Framework (DHF), benefitting from the lessons learnt during the three-year life span of the FP7 Synergy-COPD project. The DHF aims to embrace the emerging requirements--data and tools--of applying systems medicine into healthcare with a three-tier strategy articulating formal healthcare, informal care and biomedical research. Accordingly, it has been constructed based on three key building blocks, namely, novel integrated care services with the support of information and communication technologies, a personal health folder (PHF) and a biomedical research environment (DHF-research). Details on the functional requirements and necessary components of the DHF-research are extensively presented. Finally, the specifics of the building blocks strategy for deployment of the DHF, as well as the steps toward adoption are analyzed. The proposed architectural solutions and implementation steps constitute a pivotal strategy to foster and enable 4P medicine (Predictive, Preventive, Personalized and Participatory) in practice and should provide a head start to any community and institution currently considering to implement a biomedical research platform.

Show MeSH
The holistic approach intrinsic to system medicine of non-communicable diseases (NCDs) prompts the need for multilevel integration of heterogeneous patient information generated by different data sources, namely: environmental, clinical and biological data.
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Figure 1: The holistic approach intrinsic to system medicine of non-communicable diseases (NCDs) prompts the need for multilevel integration of heterogeneous patient information generated by different data sources, namely: environmental, clinical and biological data.

Mentions: It is well accepted that predictive medicine is opening entirely new and fascinating scenarios for the interplay between clinical practice and biomedical research. However, at the same time, it is generating novel requirements with impact on adoption. Firstly, the need for multilevel integration of heterogeneous patient information (Figure 1), namely: socio-economical, life-style, behavioural, clinical, physiological, cellular and "omics" data [3] and their use for the design of a personalised digital patient from virtual physiological models. Secondly, the need to extend current trends on open data from the biomedical community [4] to the clinical practice and the whole society, by engaging citizens and solving privacy and regulatory constraints, Finally, the need for highly applicable user-profiled functionalities for data management and knowledge generation. Accordingly, innovative and robust Information and Communication Technologies (ICT) will be needed as supporting tools to overcome well identified current functional limitations [5].


Biomedical research in a Digital Health Framework.

Cano I, Lluch-Ariet M, Gomez-Cabrero D, Maier D, Kalko S, Cascante M, Tegnér J, Miralles F, Herrera D, Roca J, Synergy-COPD consorti - J Transl Med (2014)

The holistic approach intrinsic to system medicine of non-communicable diseases (NCDs) prompts the need for multilevel integration of heterogeneous patient information generated by different data sources, namely: environmental, clinical and biological data.
© Copyright Policy - open-access
Related In: Results  -  Collection

License 1 - License 2
Show All Figures
getmorefigures.php?uid=PMC4255881&req=5

Figure 1: The holistic approach intrinsic to system medicine of non-communicable diseases (NCDs) prompts the need for multilevel integration of heterogeneous patient information generated by different data sources, namely: environmental, clinical and biological data.
Mentions: It is well accepted that predictive medicine is opening entirely new and fascinating scenarios for the interplay between clinical practice and biomedical research. However, at the same time, it is generating novel requirements with impact on adoption. Firstly, the need for multilevel integration of heterogeneous patient information (Figure 1), namely: socio-economical, life-style, behavioural, clinical, physiological, cellular and "omics" data [3] and their use for the design of a personalised digital patient from virtual physiological models. Secondly, the need to extend current trends on open data from the biomedical community [4] to the clinical practice and the whole society, by engaging citizens and solving privacy and regulatory constraints, Finally, the need for highly applicable user-profiled functionalities for data management and knowledge generation. Accordingly, innovative and robust Information and Communication Technologies (ICT) will be needed as supporting tools to overcome well identified current functional limitations [5].

Bottom Line: This article describes a Digital Health Framework (DHF), benefitting from the lessons learnt during the three-year life span of the FP7 Synergy-COPD project.Finally, the specifics of the building blocks strategy for deployment of the DHF, as well as the steps toward adoption are analyzed.The proposed architectural solutions and implementation steps constitute a pivotal strategy to foster and enable 4P medicine (Predictive, Preventive, Personalized and Participatory) in practice and should provide a head start to any community and institution currently considering to implement a biomedical research platform.

View Article: PubMed Central - HTML - PubMed

ABSTRACT
This article describes a Digital Health Framework (DHF), benefitting from the lessons learnt during the three-year life span of the FP7 Synergy-COPD project. The DHF aims to embrace the emerging requirements--data and tools--of applying systems medicine into healthcare with a three-tier strategy articulating formal healthcare, informal care and biomedical research. Accordingly, it has been constructed based on three key building blocks, namely, novel integrated care services with the support of information and communication technologies, a personal health folder (PHF) and a biomedical research environment (DHF-research). Details on the functional requirements and necessary components of the DHF-research are extensively presented. Finally, the specifics of the building blocks strategy for deployment of the DHF, as well as the steps toward adoption are analyzed. The proposed architectural solutions and implementation steps constitute a pivotal strategy to foster and enable 4P medicine (Predictive, Preventive, Personalized and Participatory) in practice and should provide a head start to any community and institution currently considering to implement a biomedical research platform.

Show MeSH