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The 24 h pattern of arterial pressure in mice is determined mainly by heart rate-driven variation in cardiac output.

Kurtz TW, Lujan HL, DiCarlo SE - Physiol Rep (2014)

Bottom Line: Understanding the hemodynamic mechanisms that determine the 24 h patterns of blood pressure may lead to a better understanding of how such patterns become disturbed in hypertension and influence risk for cardiovascular events.The higher arterial pressure during the nighttime period was mediated by higher cardiac output (+2.6 ± 0.3 mL/min, [26%], P < 0.05) in association with lower peripheral resistance (-1.5 ± 0.3 mmHg/mL/min, [-13%] P < 0.05).These findings suggest that the differences in blood pressure between nighttime and daytime are mainly driven by differences in heart rate which are strongly correlated with differences in locomotor activity.

View Article: PubMed Central - PubMed

Affiliation: Department of Laboratory Medicine, University of California, San Francisco, San Francisco, California.

No MeSH data available.


Related in: MedlinePlus

High‐fidelity 5‐sec original recordings of arterial pressure (panel A) and ascending aortic blood flow (cardiac output, panel B) during the daytime resting period from a chronically instrumented mouse are shown. Units for cardiac output (panel B) are expressed in kHz (left y‐axis) and mL/min (right y‐axis).
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fig01: High‐fidelity 5‐sec original recordings of arterial pressure (panel A) and ascending aortic blood flow (cardiac output, panel B) during the daytime resting period from a chronically instrumented mouse are shown. Units for cardiac output (panel B) are expressed in kHz (left y‐axis) and mL/min (right y‐axis).

Mentions: Cardiac output was recorded by securing the flow probe leads to multi‐stranded stainless steel wires from a miniature electric swivel (catalog # FL‐2‐C‐Micro; Dragonfly Research and Development, INC., Ridgeley, WV) and the mouse cage was placed on radio‐telemetry receivers. This permitted 24‐h recording of arterial pressure, heart rate, cardiac output, and locomotor activity (Fig. 1). Total peripheral resistance and stroke volume were calculated as described below.


The 24 h pattern of arterial pressure in mice is determined mainly by heart rate-driven variation in cardiac output.

Kurtz TW, Lujan HL, DiCarlo SE - Physiol Rep (2014)

High‐fidelity 5‐sec original recordings of arterial pressure (panel A) and ascending aortic blood flow (cardiac output, panel B) during the daytime resting period from a chronically instrumented mouse are shown. Units for cardiac output (panel B) are expressed in kHz (left y‐axis) and mL/min (right y‐axis).
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4255824&req=5

fig01: High‐fidelity 5‐sec original recordings of arterial pressure (panel A) and ascending aortic blood flow (cardiac output, panel B) during the daytime resting period from a chronically instrumented mouse are shown. Units for cardiac output (panel B) are expressed in kHz (left y‐axis) and mL/min (right y‐axis).
Mentions: Cardiac output was recorded by securing the flow probe leads to multi‐stranded stainless steel wires from a miniature electric swivel (catalog # FL‐2‐C‐Micro; Dragonfly Research and Development, INC., Ridgeley, WV) and the mouse cage was placed on radio‐telemetry receivers. This permitted 24‐h recording of arterial pressure, heart rate, cardiac output, and locomotor activity (Fig. 1). Total peripheral resistance and stroke volume were calculated as described below.

Bottom Line: Understanding the hemodynamic mechanisms that determine the 24 h patterns of blood pressure may lead to a better understanding of how such patterns become disturbed in hypertension and influence risk for cardiovascular events.The higher arterial pressure during the nighttime period was mediated by higher cardiac output (+2.6 ± 0.3 mL/min, [26%], P < 0.05) in association with lower peripheral resistance (-1.5 ± 0.3 mmHg/mL/min, [-13%] P < 0.05).These findings suggest that the differences in blood pressure between nighttime and daytime are mainly driven by differences in heart rate which are strongly correlated with differences in locomotor activity.

View Article: PubMed Central - PubMed

Affiliation: Department of Laboratory Medicine, University of California, San Francisco, San Francisco, California.

No MeSH data available.


Related in: MedlinePlus