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Increased microvascular vasodilation and cardiovascular risk following a pre-eclamptic pregnancy.

Murphy MS, Vignarajah M, Smith GN - Physiol Rep (2014)

Bottom Line: Acetylcholine-mediated vasodilation was enhanced by normotensive pregnancy, and declined to nonpregnant levels by 6 months postpartum.Acetylcholine-mediated vasodilation remained high in pre-eclamptic subjects from 2 to 6 months postpartum compared to normotensive and never-pregnant controls.Pre-eclamptic subjects exhibited elevated 30-year and lifetime risk at 6 months postpartum.

View Article: PubMed Central - PubMed

Affiliation: Department of Biomedical and Molecular Science, Queen's University, Kingston, Ontario, Canada.

No MeSH data available.


Related in: MedlinePlus

Comparison of microvascular responses at 6 weeks postpartum and 6 months postpartum to ACh and SNP. Data are presented as mean ± SEM. NP, never‐pregnant (n = 15); CTRL, normotensive control, (n = 23); PE at 6 weeks postpartum (n = 15), PE at 6 months postpartum (n = 25); posthoc comparisons*P < 0.05; **P < 0.01.
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fig03: Comparison of microvascular responses at 6 weeks postpartum and 6 months postpartum to ACh and SNP. Data are presented as mean ± SEM. NP, never‐pregnant (n = 15); CTRL, normotensive control, (n = 23); PE at 6 weeks postpartum (n = 15), PE at 6 months postpartum (n = 25); posthoc comparisons*P < 0.05; **P < 0.01.

Mentions: Microvascular reactivity to ACh and SNP was unchanged from 6 weeks to 6 months postpartum in 12 (n = 12) PE subjects. Maximal perfusion responses to ACh were not different at 6 weeks postpartum, but were significantly elevated in PE subjects compared to controls at 6 months postpartum. Postpartum vascular responses to SNP did not differ. To better assess the effect of PE on microvascular function at 6 months postpartum, data from an additional 10 PE subjects was included (Fig. 3). Baseline characteristics and microvascular measurements for these additional subjects did not differ from the initial PE group. For this reason, the additional data is included in Table 1 and Figure 3.


Increased microvascular vasodilation and cardiovascular risk following a pre-eclamptic pregnancy.

Murphy MS, Vignarajah M, Smith GN - Physiol Rep (2014)

Comparison of microvascular responses at 6 weeks postpartum and 6 months postpartum to ACh and SNP. Data are presented as mean ± SEM. NP, never‐pregnant (n = 15); CTRL, normotensive control, (n = 23); PE at 6 weeks postpartum (n = 15), PE at 6 months postpartum (n = 25); posthoc comparisons*P < 0.05; **P < 0.01.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4255821&req=5

fig03: Comparison of microvascular responses at 6 weeks postpartum and 6 months postpartum to ACh and SNP. Data are presented as mean ± SEM. NP, never‐pregnant (n = 15); CTRL, normotensive control, (n = 23); PE at 6 weeks postpartum (n = 15), PE at 6 months postpartum (n = 25); posthoc comparisons*P < 0.05; **P < 0.01.
Mentions: Microvascular reactivity to ACh and SNP was unchanged from 6 weeks to 6 months postpartum in 12 (n = 12) PE subjects. Maximal perfusion responses to ACh were not different at 6 weeks postpartum, but were significantly elevated in PE subjects compared to controls at 6 months postpartum. Postpartum vascular responses to SNP did not differ. To better assess the effect of PE on microvascular function at 6 months postpartum, data from an additional 10 PE subjects was included (Fig. 3). Baseline characteristics and microvascular measurements for these additional subjects did not differ from the initial PE group. For this reason, the additional data is included in Table 1 and Figure 3.

Bottom Line: Acetylcholine-mediated vasodilation was enhanced by normotensive pregnancy, and declined to nonpregnant levels by 6 months postpartum.Acetylcholine-mediated vasodilation remained high in pre-eclamptic subjects from 2 to 6 months postpartum compared to normotensive and never-pregnant controls.Pre-eclamptic subjects exhibited elevated 30-year and lifetime risk at 6 months postpartum.

View Article: PubMed Central - PubMed

Affiliation: Department of Biomedical and Molecular Science, Queen's University, Kingston, Ontario, Canada.

No MeSH data available.


Related in: MedlinePlus