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Resistance exercise increases active MMP and β1-integrin protein expression in skeletal muscle.

Ogasawara R, Nakazato K, Sato K, Boppart MD, Fujita S - Physiol Rep (2014)

Bottom Line: Recent studies indicate that matrix metalloproteinases (MMPs) and critical linkage proteins in the extracellular matrix (ECM) regulate skeletal muscle mass, although the effects of resistance training (RT) on protein expression and activity are unclear.However, β1-integrin protein expression was significantly increased (P < 0.05) with 18B.Our results suggest that resistance exercise activates MMPs during the initial phase of RT but this response is attenuated with continuation of RT.

View Article: PubMed Central - PubMed

Affiliation: Department of Life Sciences, The University of Tokyo, Tokyo, Japan Faculty of Sport and Health Science, Ritsumeikan University, Shiga, Japan.

No MeSH data available.


Related in: MedlinePlus

Effect of acute and chronic resistance exercise on matrix metalloproteinase (MMP) activity. Values are the mean ± SEM. 1B, 1 bout group; 18B, 18 bouts group; C, control muscle; E, exercised muscle. n = 2 for each condition. *P <0.05 versus control muscle; +, P <0.05 main effect of exercise (no interaction).
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fig01: Effect of acute and chronic resistance exercise on matrix metalloproteinase (MMP) activity. Values are the mean ± SEM. 1B, 1 bout group; 18B, 18 bouts group; C, control muscle; E, exercised muscle. n = 2 for each condition. *P <0.05 versus control muscle; +, P <0.05 main effect of exercise (no interaction).

Mentions: A single bout of electrical stimulation elevated the level of active MMP‐2, pro‐MMP‐9, and active MMP‐9; a similar increase in pro‐MMP‐9 was observed with 18B (Fig. 1). However, repeated bouts of muscle contraction blunted the level of active MMP‐2 and MMP‐9 with 18B.


Resistance exercise increases active MMP and β1-integrin protein expression in skeletal muscle.

Ogasawara R, Nakazato K, Sato K, Boppart MD, Fujita S - Physiol Rep (2014)

Effect of acute and chronic resistance exercise on matrix metalloproteinase (MMP) activity. Values are the mean ± SEM. 1B, 1 bout group; 18B, 18 bouts group; C, control muscle; E, exercised muscle. n = 2 for each condition. *P <0.05 versus control muscle; +, P <0.05 main effect of exercise (no interaction).
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4255818&req=5

fig01: Effect of acute and chronic resistance exercise on matrix metalloproteinase (MMP) activity. Values are the mean ± SEM. 1B, 1 bout group; 18B, 18 bouts group; C, control muscle; E, exercised muscle. n = 2 for each condition. *P <0.05 versus control muscle; +, P <0.05 main effect of exercise (no interaction).
Mentions: A single bout of electrical stimulation elevated the level of active MMP‐2, pro‐MMP‐9, and active MMP‐9; a similar increase in pro‐MMP‐9 was observed with 18B (Fig. 1). However, repeated bouts of muscle contraction blunted the level of active MMP‐2 and MMP‐9 with 18B.

Bottom Line: Recent studies indicate that matrix metalloproteinases (MMPs) and critical linkage proteins in the extracellular matrix (ECM) regulate skeletal muscle mass, although the effects of resistance training (RT) on protein expression and activity are unclear.However, β1-integrin protein expression was significantly increased (P < 0.05) with 18B.Our results suggest that resistance exercise activates MMPs during the initial phase of RT but this response is attenuated with continuation of RT.

View Article: PubMed Central - PubMed

Affiliation: Department of Life Sciences, The University of Tokyo, Tokyo, Japan Faculty of Sport and Health Science, Ritsumeikan University, Shiga, Japan.

No MeSH data available.


Related in: MedlinePlus