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Preserved functional autonomic phenotype in adult mice overexpressing moderate levels of human alpha-synuclein in oligodendrocytes.

Tank J, da Costa-Goncalves AC, Kamer I, Qadri F, Ubhi K, Rockenstein E, Diedrich A, Masliah E, Gross V, Jordan J - Physiol Rep (2014)

Bottom Line: HR responses to atropine (+159 ± 24 vs. +146 ± 22 beats/min), and to clonidine (-188 ± 21 vs. -163 ± 33 beats/min) did not differ between strains.Baroreflex sensitivity (4 ± 1 vs. 4 ± 1 msec/mmHg) and HR variability (total power, 84 ± 17 vs. 65 ± 21 msec²) were similar under resting conditions and during pharmacological testing.Repeated measurements at 12 months of age provided similar results.

View Article: PubMed Central - PubMed

Affiliation: Institute of Clinical Pharmacology, Hannover Medical School, Hannover, Germany.

No MeSH data available.


Related in: MedlinePlus

Responses (Δ) of heart rate (HR), heart rate variability in the time domain (rmssd = root mean square of successive differences), heart rate variability in the frequency domain (TP = total power, LF = power in the low‐frequency range, HF = power in the high‐frequency range), systolic blood pressure variability in the low‐frequency range (LFsys) and baroreflex sensitivity calculated by cross‐spectral analysis (BRS‐LF) or by the sequence technique (BRS‐up, BRS‐down) to atropine (2 mg/kg) in MBP1‐α‐syn (tg) and in wild‐type (wt) mice at 9 months of age.
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fig05: Responses (Δ) of heart rate (HR), heart rate variability in the time domain (rmssd = root mean square of successive differences), heart rate variability in the frequency domain (TP = total power, LF = power in the low‐frequency range, HF = power in the high‐frequency range), systolic blood pressure variability in the low‐frequency range (LFsys) and baroreflex sensitivity calculated by cross‐spectral analysis (BRS‐LF) or by the sequence technique (BRS‐up, BRS‐down) to atropine (2 mg/kg) in MBP1‐α‐syn (tg) and in wild‐type (wt) mice at 9 months of age.

Mentions: Baroreflex sensitivity (BRS‐LF, tg: 4 ± 1 vs. wt: 4 ± 1 msec/mmHg) and HR variability (total power, tg: 84 ± 17 vs. wt: 65 ± 21 msec²) were similar under resting conditions and during pharmacological testing. Figure 5 illustrates changes in HR, HR variability, and baroreflex sensitivity in response to atropine. A similar increase in HR after atropine (tg: +159 ± 24 vs. wt: +146 ± 22 beats/min) was accompanied by similar decreases in HR variability in the time and frequency domains. Moreover, BP variability in the low‐frequency band increased by the same amount in both strains. Baroreflex sensitivity measured with the cross‐spectral method in the low‐frequency range as well as with the sequence technique was reduced by the same amount in both strains. Pharmacological testing at 12 months of age provided similar results.


Preserved functional autonomic phenotype in adult mice overexpressing moderate levels of human alpha-synuclein in oligodendrocytes.

Tank J, da Costa-Goncalves AC, Kamer I, Qadri F, Ubhi K, Rockenstein E, Diedrich A, Masliah E, Gross V, Jordan J - Physiol Rep (2014)

Responses (Δ) of heart rate (HR), heart rate variability in the time domain (rmssd = root mean square of successive differences), heart rate variability in the frequency domain (TP = total power, LF = power in the low‐frequency range, HF = power in the high‐frequency range), systolic blood pressure variability in the low‐frequency range (LFsys) and baroreflex sensitivity calculated by cross‐spectral analysis (BRS‐LF) or by the sequence technique (BRS‐up, BRS‐down) to atropine (2 mg/kg) in MBP1‐α‐syn (tg) and in wild‐type (wt) mice at 9 months of age.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4255815&req=5

fig05: Responses (Δ) of heart rate (HR), heart rate variability in the time domain (rmssd = root mean square of successive differences), heart rate variability in the frequency domain (TP = total power, LF = power in the low‐frequency range, HF = power in the high‐frequency range), systolic blood pressure variability in the low‐frequency range (LFsys) and baroreflex sensitivity calculated by cross‐spectral analysis (BRS‐LF) or by the sequence technique (BRS‐up, BRS‐down) to atropine (2 mg/kg) in MBP1‐α‐syn (tg) and in wild‐type (wt) mice at 9 months of age.
Mentions: Baroreflex sensitivity (BRS‐LF, tg: 4 ± 1 vs. wt: 4 ± 1 msec/mmHg) and HR variability (total power, tg: 84 ± 17 vs. wt: 65 ± 21 msec²) were similar under resting conditions and during pharmacological testing. Figure 5 illustrates changes in HR, HR variability, and baroreflex sensitivity in response to atropine. A similar increase in HR after atropine (tg: +159 ± 24 vs. wt: +146 ± 22 beats/min) was accompanied by similar decreases in HR variability in the time and frequency domains. Moreover, BP variability in the low‐frequency band increased by the same amount in both strains. Baroreflex sensitivity measured with the cross‐spectral method in the low‐frequency range as well as with the sequence technique was reduced by the same amount in both strains. Pharmacological testing at 12 months of age provided similar results.

Bottom Line: HR responses to atropine (+159 ± 24 vs. +146 ± 22 beats/min), and to clonidine (-188 ± 21 vs. -163 ± 33 beats/min) did not differ between strains.Baroreflex sensitivity (4 ± 1 vs. 4 ± 1 msec/mmHg) and HR variability (total power, 84 ± 17 vs. 65 ± 21 msec²) were similar under resting conditions and during pharmacological testing.Repeated measurements at 12 months of age provided similar results.

View Article: PubMed Central - PubMed

Affiliation: Institute of Clinical Pharmacology, Hannover Medical School, Hannover, Germany.

No MeSH data available.


Related in: MedlinePlus