Limits...
Preserved functional autonomic phenotype in adult mice overexpressing moderate levels of human alpha-synuclein in oligodendrocytes.

Tank J, da Costa-Goncalves AC, Kamer I, Qadri F, Ubhi K, Rockenstein E, Diedrich A, Masliah E, Gross V, Jordan J - Physiol Rep (2014)

Bottom Line: HR responses to atropine (+159 ± 24 vs. +146 ± 22 beats/min), and to clonidine (-188 ± 21 vs. -163 ± 33 beats/min) did not differ between strains.Baroreflex sensitivity (4 ± 1 vs. 4 ± 1 msec/mmHg) and HR variability (total power, 84 ± 17 vs. 65 ± 21 msec²) were similar under resting conditions and during pharmacological testing.Repeated measurements at 12 months of age provided similar results.

View Article: PubMed Central - PubMed

Affiliation: Institute of Clinical Pharmacology, Hannover Medical School, Hannover, Germany.

No MeSH data available.


Related in: MedlinePlus

Individual BP changes in wild‐type (wt) and in MBP1‐α‐syn (tg) mice in response to trimethaphan (left) and clonidine (right). Changes in BP and HR are expressed as change relative to 1‐h baseline prior to drug administration.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
getmorefigures.php?uid=PMC4255815&req=5

fig04: Individual BP changes in wild‐type (wt) and in MBP1‐α‐syn (tg) mice in response to trimethaphan (left) and clonidine (right). Changes in BP and HR are expressed as change relative to 1‐h baseline prior to drug administration.

Mentions: Figure 4 illustrates individual BP responses to trimethaphan and clonidine compared to baseline in transgenic and in wild‐type mice. These responses did not significantly differ between strains. Numerically, transgenic animals tended to have a more pronounced depressor response. However, the difference between groups was rather small and much less than in human MSA.


Preserved functional autonomic phenotype in adult mice overexpressing moderate levels of human alpha-synuclein in oligodendrocytes.

Tank J, da Costa-Goncalves AC, Kamer I, Qadri F, Ubhi K, Rockenstein E, Diedrich A, Masliah E, Gross V, Jordan J - Physiol Rep (2014)

Individual BP changes in wild‐type (wt) and in MBP1‐α‐syn (tg) mice in response to trimethaphan (left) and clonidine (right). Changes in BP and HR are expressed as change relative to 1‐h baseline prior to drug administration.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4255815&req=5

fig04: Individual BP changes in wild‐type (wt) and in MBP1‐α‐syn (tg) mice in response to trimethaphan (left) and clonidine (right). Changes in BP and HR are expressed as change relative to 1‐h baseline prior to drug administration.
Mentions: Figure 4 illustrates individual BP responses to trimethaphan and clonidine compared to baseline in transgenic and in wild‐type mice. These responses did not significantly differ between strains. Numerically, transgenic animals tended to have a more pronounced depressor response. However, the difference between groups was rather small and much less than in human MSA.

Bottom Line: HR responses to atropine (+159 ± 24 vs. +146 ± 22 beats/min), and to clonidine (-188 ± 21 vs. -163 ± 33 beats/min) did not differ between strains.Baroreflex sensitivity (4 ± 1 vs. 4 ± 1 msec/mmHg) and HR variability (total power, 84 ± 17 vs. 65 ± 21 msec²) were similar under resting conditions and during pharmacological testing.Repeated measurements at 12 months of age provided similar results.

View Article: PubMed Central - PubMed

Affiliation: Institute of Clinical Pharmacology, Hannover Medical School, Hannover, Germany.

No MeSH data available.


Related in: MedlinePlus