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Preserved functional autonomic phenotype in adult mice overexpressing moderate levels of human alpha-synuclein in oligodendrocytes.

Tank J, da Costa-Goncalves AC, Kamer I, Qadri F, Ubhi K, Rockenstein E, Diedrich A, Masliah E, Gross V, Jordan J - Physiol Rep (2014)

Bottom Line: HR responses to atropine (+159 ± 24 vs. +146 ± 22 beats/min), and to clonidine (-188 ± 21 vs. -163 ± 33 beats/min) did not differ between strains.Baroreflex sensitivity (4 ± 1 vs. 4 ± 1 msec/mmHg) and HR variability (total power, 84 ± 17 vs. 65 ± 21 msec²) were similar under resting conditions and during pharmacological testing.Repeated measurements at 12 months of age provided similar results.

View Article: PubMed Central - PubMed

Affiliation: Institute of Clinical Pharmacology, Hannover Medical School, Hannover, Germany.

No MeSH data available.


Related in: MedlinePlus

Heart rate (HR, bottom) and mean arterial pressure (MAP, top) after i.p. injection of 1 mg/kg clonidine (left) and after i.p. injection of 40 mg/kg trimethaphan (right) in MBP1‐α‐syn and in wild‐type mice at 9 months of age. The initial high absolute values after returning the mice to the cage are caused by stress and were not used for analysis.
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fig03: Heart rate (HR, bottom) and mean arterial pressure (MAP, top) after i.p. injection of 1 mg/kg clonidine (left) and after i.p. injection of 40 mg/kg trimethaphan (right) in MBP1‐α‐syn and in wild‐type mice at 9 months of age. The initial high absolute values after returning the mice to the cage are caused by stress and were not used for analysis.

Mentions: Transgenic MBP1‐α‐syn showed a trend of reduced ChAT‐positive cells in the nucleus ambiguous compared to wild‐type mice (Fig. 2, P = 0.1028). Mean arterial blood pressure responses to trimethaphan (tg: −21 ± 8 vs. wt: −10 ± 5 mmHg, P = 0.240) and to clonidine (tg: −8 ± 3 vs. wt: −5 ± 2 mmHg, P = 0.314) were similar in both strains. HR responses to trimethaphan (tg: −90 ± 25 vs. wt: −98 ± 22 beats/min), and to clonidine (tg: −188 ± 21 vs. wt: −163 ± 33 beats/min) did not differ between strains. Figure 3 shows the BP and HR values measured for 1 h immediately after the drug injection during pharmacological testing at 9 months of age. We obtained similar results during pharmacological testing at 9 and 12 months of age. The time courses of BP and HR responses were almost identical in both strains.


Preserved functional autonomic phenotype in adult mice overexpressing moderate levels of human alpha-synuclein in oligodendrocytes.

Tank J, da Costa-Goncalves AC, Kamer I, Qadri F, Ubhi K, Rockenstein E, Diedrich A, Masliah E, Gross V, Jordan J - Physiol Rep (2014)

Heart rate (HR, bottom) and mean arterial pressure (MAP, top) after i.p. injection of 1 mg/kg clonidine (left) and after i.p. injection of 40 mg/kg trimethaphan (right) in MBP1‐α‐syn and in wild‐type mice at 9 months of age. The initial high absolute values after returning the mice to the cage are caused by stress and were not used for analysis.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4255815&req=5

fig03: Heart rate (HR, bottom) and mean arterial pressure (MAP, top) after i.p. injection of 1 mg/kg clonidine (left) and after i.p. injection of 40 mg/kg trimethaphan (right) in MBP1‐α‐syn and in wild‐type mice at 9 months of age. The initial high absolute values after returning the mice to the cage are caused by stress and were not used for analysis.
Mentions: Transgenic MBP1‐α‐syn showed a trend of reduced ChAT‐positive cells in the nucleus ambiguous compared to wild‐type mice (Fig. 2, P = 0.1028). Mean arterial blood pressure responses to trimethaphan (tg: −21 ± 8 vs. wt: −10 ± 5 mmHg, P = 0.240) and to clonidine (tg: −8 ± 3 vs. wt: −5 ± 2 mmHg, P = 0.314) were similar in both strains. HR responses to trimethaphan (tg: −90 ± 25 vs. wt: −98 ± 22 beats/min), and to clonidine (tg: −188 ± 21 vs. wt: −163 ± 33 beats/min) did not differ between strains. Figure 3 shows the BP and HR values measured for 1 h immediately after the drug injection during pharmacological testing at 9 months of age. We obtained similar results during pharmacological testing at 9 and 12 months of age. The time courses of BP and HR responses were almost identical in both strains.

Bottom Line: HR responses to atropine (+159 ± 24 vs. +146 ± 22 beats/min), and to clonidine (-188 ± 21 vs. -163 ± 33 beats/min) did not differ between strains.Baroreflex sensitivity (4 ± 1 vs. 4 ± 1 msec/mmHg) and HR variability (total power, 84 ± 17 vs. 65 ± 21 msec²) were similar under resting conditions and during pharmacological testing.Repeated measurements at 12 months of age provided similar results.

View Article: PubMed Central - PubMed

Affiliation: Institute of Clinical Pharmacology, Hannover Medical School, Hannover, Germany.

No MeSH data available.


Related in: MedlinePlus