Limits...
Preserved functional autonomic phenotype in adult mice overexpressing moderate levels of human alpha-synuclein in oligodendrocytes.

Tank J, da Costa-Goncalves AC, Kamer I, Qadri F, Ubhi K, Rockenstein E, Diedrich A, Masliah E, Gross V, Jordan J - Physiol Rep (2014)

Bottom Line: HR responses to atropine (+159 ± 24 vs. +146 ± 22 beats/min), and to clonidine (-188 ± 21 vs. -163 ± 33 beats/min) did not differ between strains.Baroreflex sensitivity (4 ± 1 vs. 4 ± 1 msec/mmHg) and HR variability (total power, 84 ± 17 vs. 65 ± 21 msec²) were similar under resting conditions and during pharmacological testing.Repeated measurements at 12 months of age provided similar results.

View Article: PubMed Central - PubMed

Affiliation: Institute of Clinical Pharmacology, Hannover Medical School, Hannover, Germany.

No MeSH data available.


Related in: MedlinePlus

Circadian variations in heart rate (HR, top‐left) and mean arterial blood pressure (MAP, top‐right) measured over 3 days in MBP1‐α‐syn (tg) mice (transgenic) and in wild‐type mice (wild type) at 9 and 12 months of age. Distribution of alpha‐synuclein in MBP1‐α‐syn tg mice (bottom). The sagittal vibratome section is immunolabeled with an antibody against alpha‐synuclein (rabbit polyclonal from Millipore) illustrating the distribution of the alpha‐synuclein aggregates in oligodendroglial cells in various cortical and subcortical brain regions. Of the subcortical regions affected included those involved in hemodynamical regulation such as rostral ventrolateral medulla (RVLM), nucleus tractus solitarius (NTS), and dorsal vagus nucleus (DVN). The inset displays the alpha‐synuclein aggregates in oligodendroglial cells in the MBP1‐α‐syn mice as compared to a wild‐type control. Bar = 250 µm for the low power image and 10 µm for the inset.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
getmorefigures.php?uid=PMC4255815&req=5

fig01: Circadian variations in heart rate (HR, top‐left) and mean arterial blood pressure (MAP, top‐right) measured over 3 days in MBP1‐α‐syn (tg) mice (transgenic) and in wild‐type mice (wild type) at 9 and 12 months of age. Distribution of alpha‐synuclein in MBP1‐α‐syn tg mice (bottom). The sagittal vibratome section is immunolabeled with an antibody against alpha‐synuclein (rabbit polyclonal from Millipore) illustrating the distribution of the alpha‐synuclein aggregates in oligodendroglial cells in various cortical and subcortical brain regions. Of the subcortical regions affected included those involved in hemodynamical regulation such as rostral ventrolateral medulla (RVLM), nucleus tractus solitarius (NTS), and dorsal vagus nucleus (DVN). The inset displays the alpha‐synuclein aggregates in oligodendroglial cells in the MBP1‐α‐syn mice as compared to a wild‐type control. Bar = 250 µm for the low power image and 10 µm for the inset.

Mentions: At 9 months of age daytime blood pressure (tg: 101 ± 2 vs. wt: 99 ± 2 mmHg) and heart rate (tg: 497 ± 11 vs. wt: 505 ± 16 beats/min) were similar in MBP1‐α‐syn mice and in wild‐type mice. Circadian blood pressure and heart rate rhythms were maintained in MBP1‐α‐syn mice. Nighttime BP (tg: 109 ± 2 vs. wt: 108 ± 2 mmHg) and HR (tg: 575 ± 15 vs. wt: 569 ± 14 beats/min) were similar in both strains. Similar results were obtained at 12 months of age. Circadian variations in blood pressure and heart rate measured over 3 days for transgenic MBP1‐α‐syn and wild‐type mice at 9 and 12 months of age are illustrated in Figure 1 together with immunohistochemical staining of alpha‐synuclein in the brain of wild‐type and transgenic mice (bottom).


Preserved functional autonomic phenotype in adult mice overexpressing moderate levels of human alpha-synuclein in oligodendrocytes.

Tank J, da Costa-Goncalves AC, Kamer I, Qadri F, Ubhi K, Rockenstein E, Diedrich A, Masliah E, Gross V, Jordan J - Physiol Rep (2014)

Circadian variations in heart rate (HR, top‐left) and mean arterial blood pressure (MAP, top‐right) measured over 3 days in MBP1‐α‐syn (tg) mice (transgenic) and in wild‐type mice (wild type) at 9 and 12 months of age. Distribution of alpha‐synuclein in MBP1‐α‐syn tg mice (bottom). The sagittal vibratome section is immunolabeled with an antibody against alpha‐synuclein (rabbit polyclonal from Millipore) illustrating the distribution of the alpha‐synuclein aggregates in oligodendroglial cells in various cortical and subcortical brain regions. Of the subcortical regions affected included those involved in hemodynamical regulation such as rostral ventrolateral medulla (RVLM), nucleus tractus solitarius (NTS), and dorsal vagus nucleus (DVN). The inset displays the alpha‐synuclein aggregates in oligodendroglial cells in the MBP1‐α‐syn mice as compared to a wild‐type control. Bar = 250 µm for the low power image and 10 µm for the inset.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4255815&req=5

fig01: Circadian variations in heart rate (HR, top‐left) and mean arterial blood pressure (MAP, top‐right) measured over 3 days in MBP1‐α‐syn (tg) mice (transgenic) and in wild‐type mice (wild type) at 9 and 12 months of age. Distribution of alpha‐synuclein in MBP1‐α‐syn tg mice (bottom). The sagittal vibratome section is immunolabeled with an antibody against alpha‐synuclein (rabbit polyclonal from Millipore) illustrating the distribution of the alpha‐synuclein aggregates in oligodendroglial cells in various cortical and subcortical brain regions. Of the subcortical regions affected included those involved in hemodynamical regulation such as rostral ventrolateral medulla (RVLM), nucleus tractus solitarius (NTS), and dorsal vagus nucleus (DVN). The inset displays the alpha‐synuclein aggregates in oligodendroglial cells in the MBP1‐α‐syn mice as compared to a wild‐type control. Bar = 250 µm for the low power image and 10 µm for the inset.
Mentions: At 9 months of age daytime blood pressure (tg: 101 ± 2 vs. wt: 99 ± 2 mmHg) and heart rate (tg: 497 ± 11 vs. wt: 505 ± 16 beats/min) were similar in MBP1‐α‐syn mice and in wild‐type mice. Circadian blood pressure and heart rate rhythms were maintained in MBP1‐α‐syn mice. Nighttime BP (tg: 109 ± 2 vs. wt: 108 ± 2 mmHg) and HR (tg: 575 ± 15 vs. wt: 569 ± 14 beats/min) were similar in both strains. Similar results were obtained at 12 months of age. Circadian variations in blood pressure and heart rate measured over 3 days for transgenic MBP1‐α‐syn and wild‐type mice at 9 and 12 months of age are illustrated in Figure 1 together with immunohistochemical staining of alpha‐synuclein in the brain of wild‐type and transgenic mice (bottom).

Bottom Line: HR responses to atropine (+159 ± 24 vs. +146 ± 22 beats/min), and to clonidine (-188 ± 21 vs. -163 ± 33 beats/min) did not differ between strains.Baroreflex sensitivity (4 ± 1 vs. 4 ± 1 msec/mmHg) and HR variability (total power, 84 ± 17 vs. 65 ± 21 msec²) were similar under resting conditions and during pharmacological testing.Repeated measurements at 12 months of age provided similar results.

View Article: PubMed Central - PubMed

Affiliation: Institute of Clinical Pharmacology, Hannover Medical School, Hannover, Germany.

No MeSH data available.


Related in: MedlinePlus