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Genetic modulation of diabetic nephropathy among mouse strains with Ins2 Akita mutation.

Wu X, Davis RC, McMillen TS, Schaeffer V, Zhou Z, Qi H, Mazandarani PN, Alialy R, Hudkins KL, Lusis AJ, LeBoeuf RC - Physiol Rep (2014)

Bottom Line: Urine albumin-to-creatinine ratios (ACRs), volume and cystatin C as well as blood urea nitrogen and lipoprotein levels varied significantly among the diabetic strains.ACRs correlated with cystatin C (P = 0.0286), a measure of hyperfiltration and an interstitial tubular marker associated with DN onset in humans suggesting that tubule damage as well as podocyte-stress contributed to reduced kidney function assessed by ACR.However, glomerular hypertrophy and collagen IV content were found to vary significantly among strains suggesting a genetic basis for early onset features of DN.

View Article: PubMed Central - PubMed

Affiliation: Division of Cardiology, Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, California, USA.

No MeSH data available.


Related in: MedlinePlus

Correlation of nephropathy‐related phenotypes among diabetic mice across a panel of 28 F1 mouse strains using BiWeight Midcorrelation (Langfelder and Horvath 2012). Color indicates positive (blue) or negative (red) correlation (Vlasakova et al. 2014). Intensity of color indicates strength of correlation as shown on the scale. For statistically significant correlations, P‐value is given within the color square.
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fig02: Correlation of nephropathy‐related phenotypes among diabetic mice across a panel of 28 F1 mouse strains using BiWeight Midcorrelation (Langfelder and Horvath 2012). Color indicates positive (blue) or negative (red) correlation (Vlasakova et al. 2014). Intensity of color indicates strength of correlation as shown on the scale. For statistically significant correlations, P‐value is given within the color square.

Mentions: Of note were the marked differences in the extent of polyuria across the Akita strains (Fig. 1B). For nondiabetic mice, values ranged 20‐fold (0.10 mL/day for BALB/c and CE to 2.20 mL/day for C3H/He) and increased robustly and significantly with diabetes for each strain. Daily urine volumes ranged 8‐fold (3.1 mL/day for RIIIS to 24 mL/day for NZB/BIN). ACR and polyuria traits did not correlate significantly across the strains (Fig. 2). For instance, BUB/Bn showed severe polyuria but reduced ACR levels as compared to NOD/ShiLt that had both polyuria and elevated ACR.


Genetic modulation of diabetic nephropathy among mouse strains with Ins2 Akita mutation.

Wu X, Davis RC, McMillen TS, Schaeffer V, Zhou Z, Qi H, Mazandarani PN, Alialy R, Hudkins KL, Lusis AJ, LeBoeuf RC - Physiol Rep (2014)

Correlation of nephropathy‐related phenotypes among diabetic mice across a panel of 28 F1 mouse strains using BiWeight Midcorrelation (Langfelder and Horvath 2012). Color indicates positive (blue) or negative (red) correlation (Vlasakova et al. 2014). Intensity of color indicates strength of correlation as shown on the scale. For statistically significant correlations, P‐value is given within the color square.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4255814&req=5

fig02: Correlation of nephropathy‐related phenotypes among diabetic mice across a panel of 28 F1 mouse strains using BiWeight Midcorrelation (Langfelder and Horvath 2012). Color indicates positive (blue) or negative (red) correlation (Vlasakova et al. 2014). Intensity of color indicates strength of correlation as shown on the scale. For statistically significant correlations, P‐value is given within the color square.
Mentions: Of note were the marked differences in the extent of polyuria across the Akita strains (Fig. 1B). For nondiabetic mice, values ranged 20‐fold (0.10 mL/day for BALB/c and CE to 2.20 mL/day for C3H/He) and increased robustly and significantly with diabetes for each strain. Daily urine volumes ranged 8‐fold (3.1 mL/day for RIIIS to 24 mL/day for NZB/BIN). ACR and polyuria traits did not correlate significantly across the strains (Fig. 2). For instance, BUB/Bn showed severe polyuria but reduced ACR levels as compared to NOD/ShiLt that had both polyuria and elevated ACR.

Bottom Line: Urine albumin-to-creatinine ratios (ACRs), volume and cystatin C as well as blood urea nitrogen and lipoprotein levels varied significantly among the diabetic strains.ACRs correlated with cystatin C (P = 0.0286), a measure of hyperfiltration and an interstitial tubular marker associated with DN onset in humans suggesting that tubule damage as well as podocyte-stress contributed to reduced kidney function assessed by ACR.However, glomerular hypertrophy and collagen IV content were found to vary significantly among strains suggesting a genetic basis for early onset features of DN.

View Article: PubMed Central - PubMed

Affiliation: Division of Cardiology, Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, California, USA.

No MeSH data available.


Related in: MedlinePlus