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DNA microarray-based analysis of voluntary resistance wheel running reveals novel transcriptome leading robust hippocampal plasticity.

Lee MC, Rakwal R, Shibato J, Inoue K, Chang H, Soya H - Physiol Rep (2014)

Bottom Line: RWR rats showed a significant decrease in average running distances although average work levels increased immensely, by about 11-fold compared to WR, resulting in muscular adaptation for the fast-twitch plantaris muscle.Interestingly, RWR down-regulated multiple inflammatory cytokines (IL1B, IL2RA, and TNF) and chemokines (CXCL1, CXCL10, CCL2, and CCR4) with the SYCP3, PRL genes, which are potentially involved in regulating hippocampal neuroplastic changes.These results provide understanding of the voluntary-RWR-related hippocampal transcriptome, which will open a window to the underlying mechanisms of the positive effects of exercise, with therapeutic value for enhancing hippocampal functions.

View Article: PubMed Central - PubMed

Affiliation: Laboratory of Exercise Biochemistry and Neuroendocrinology, Faculty of Health and Sport Sciences, University of Tsukuba, TsukubaIbaraki, Japan International Research Fellow of the Japan Society for the Promotion of Science, Tokyo, Japan.

No MeSH data available.


Related in: MedlinePlus

Differentially expressed genes in the WR and RWR. The numbers above each bar indicate the selection of genes from the total microarray datasets within a defined fold range of greater than 1.5‐fold and less than 0.75‐fold.
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fig02: Differentially expressed genes in the WR and RWR. The numbers above each bar indicate the selection of genes from the total microarray datasets within a defined fold range of greater than 1.5‐fold and less than 0.75‐fold.

Mentions: Genome‐wide global gene expression profiles were obtained for WR and RWR‐related genes. 128 (Sed × WR) and 169 (Sed × RWR) were up‐regulated (>1.5‐fold change) as compared with 97 (Sed × WR) and 468 (Sed × RWR) down‐regulated genes (<0.75‐fold change) after 4 weeks exercise, respectively (Fig. 2).


DNA microarray-based analysis of voluntary resistance wheel running reveals novel transcriptome leading robust hippocampal plasticity.

Lee MC, Rakwal R, Shibato J, Inoue K, Chang H, Soya H - Physiol Rep (2014)

Differentially expressed genes in the WR and RWR. The numbers above each bar indicate the selection of genes from the total microarray datasets within a defined fold range of greater than 1.5‐fold and less than 0.75‐fold.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4255813&req=5

fig02: Differentially expressed genes in the WR and RWR. The numbers above each bar indicate the selection of genes from the total microarray datasets within a defined fold range of greater than 1.5‐fold and less than 0.75‐fold.
Mentions: Genome‐wide global gene expression profiles were obtained for WR and RWR‐related genes. 128 (Sed × WR) and 169 (Sed × RWR) were up‐regulated (>1.5‐fold change) as compared with 97 (Sed × WR) and 468 (Sed × RWR) down‐regulated genes (<0.75‐fold change) after 4 weeks exercise, respectively (Fig. 2).

Bottom Line: RWR rats showed a significant decrease in average running distances although average work levels increased immensely, by about 11-fold compared to WR, resulting in muscular adaptation for the fast-twitch plantaris muscle.Interestingly, RWR down-regulated multiple inflammatory cytokines (IL1B, IL2RA, and TNF) and chemokines (CXCL1, CXCL10, CCL2, and CCR4) with the SYCP3, PRL genes, which are potentially involved in regulating hippocampal neuroplastic changes.These results provide understanding of the voluntary-RWR-related hippocampal transcriptome, which will open a window to the underlying mechanisms of the positive effects of exercise, with therapeutic value for enhancing hippocampal functions.

View Article: PubMed Central - PubMed

Affiliation: Laboratory of Exercise Biochemistry and Neuroendocrinology, Faculty of Health and Sport Sciences, University of Tsukuba, TsukubaIbaraki, Japan International Research Fellow of the Japan Society for the Promotion of Science, Tokyo, Japan.

No MeSH data available.


Related in: MedlinePlus