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Sympathetic overactivity prevails over the vascular amplifier phenomena in a chronic kidney disease rat model of hypertension.

Ameer OZ, Hildreth CM, Phillips JK - Physiol Rep (2014)

Bottom Line: In LPK, the ratio of the hexamethonium/vasodilator MAP responses was greater when compared with Lewis (hexamethonium/SNP 1.34 ± 0.1 vs. 0.9 ± 0.09 and hexamethonium/adenosine: 2.28 ± 0.3 vs. 1.16 ± 0.1, both P < 0.05) but not SHR.The slope of the relationship between the fall in SBP induced by hexamethonium and normalized low frequency (LFnu) power was also greater in the LPK (17.93 ± 3.26 mmHg/LFnu) compared with Lewis (2.78 ± 0.59 mmHg/LFnu, P = 0.001) and SHR (3.36 ±0.72 mmHg/LFnu, P = 0.003).These results indicate that in the LPK, sympathetic activity predominates over any vascular amplifier effect, supporting increased sympathetic vasomotor tone as a major contributor to hypertension in this model of CKD.

View Article: PubMed Central - PubMed

Affiliation: The Australian School of Advanced Medicine, Macquarie University, Sydney, New South Wales, Australia.

No MeSH data available.


Related in: MedlinePlus

Systolic blood pressure (SBP) plotted against the normalized unit of the low frequency SBP power LFnu during administration of graded i.v. boluses of the ganglionic blocker hexamethonium in Lewis, Lewis polycystic kidney (LPK) and spontaneously hypertensive rats (SHR). The relationship between SBP and LFnu power of SBP variability was analyzed using linear regression. The regression r2 values are as detailed in the Figure.
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fig05: Systolic blood pressure (SBP) plotted against the normalized unit of the low frequency SBP power LFnu during administration of graded i.v. boluses of the ganglionic blocker hexamethonium in Lewis, Lewis polycystic kidney (LPK) and spontaneously hypertensive rats (SHR). The relationship between SBP and LFnu power of SBP variability was analyzed using linear regression. The regression r2 values are as detailed in the Figure.

Mentions: The relationship between the LFnu power and SBP in the presence of ganglionic blockade is shown in Fig. 5. The slope was greater in the LPK compared with both Lewis (17.93 ± 3.26 vs. 2.78 ± 0.59 mmHg/LFnu, respectively, P =0.001) and SHR (3.36 ± 0.72 mmHg/LFnu, P =0.003).


Sympathetic overactivity prevails over the vascular amplifier phenomena in a chronic kidney disease rat model of hypertension.

Ameer OZ, Hildreth CM, Phillips JK - Physiol Rep (2014)

Systolic blood pressure (SBP) plotted against the normalized unit of the low frequency SBP power LFnu during administration of graded i.v. boluses of the ganglionic blocker hexamethonium in Lewis, Lewis polycystic kidney (LPK) and spontaneously hypertensive rats (SHR). The relationship between SBP and LFnu power of SBP variability was analyzed using linear regression. The regression r2 values are as detailed in the Figure.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4255812&req=5

fig05: Systolic blood pressure (SBP) plotted against the normalized unit of the low frequency SBP power LFnu during administration of graded i.v. boluses of the ganglionic blocker hexamethonium in Lewis, Lewis polycystic kidney (LPK) and spontaneously hypertensive rats (SHR). The relationship between SBP and LFnu power of SBP variability was analyzed using linear regression. The regression r2 values are as detailed in the Figure.
Mentions: The relationship between the LFnu power and SBP in the presence of ganglionic blockade is shown in Fig. 5. The slope was greater in the LPK compared with both Lewis (17.93 ± 3.26 vs. 2.78 ± 0.59 mmHg/LFnu, respectively, P =0.001) and SHR (3.36 ± 0.72 mmHg/LFnu, P =0.003).

Bottom Line: In LPK, the ratio of the hexamethonium/vasodilator MAP responses was greater when compared with Lewis (hexamethonium/SNP 1.34 ± 0.1 vs. 0.9 ± 0.09 and hexamethonium/adenosine: 2.28 ± 0.3 vs. 1.16 ± 0.1, both P < 0.05) but not SHR.The slope of the relationship between the fall in SBP induced by hexamethonium and normalized low frequency (LFnu) power was also greater in the LPK (17.93 ± 3.26 mmHg/LFnu) compared with Lewis (2.78 ± 0.59 mmHg/LFnu, P = 0.001) and SHR (3.36 ±0.72 mmHg/LFnu, P = 0.003).These results indicate that in the LPK, sympathetic activity predominates over any vascular amplifier effect, supporting increased sympathetic vasomotor tone as a major contributor to hypertension in this model of CKD.

View Article: PubMed Central - PubMed

Affiliation: The Australian School of Advanced Medicine, Macquarie University, Sydney, New South Wales, Australia.

No MeSH data available.


Related in: MedlinePlus