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Impact of gastric emptying to the glycemic and insulinemic responses to a 75-g oral glucose load in older subjects with normal and impaired glucose tolerance.

Trahair LG, Horowitz M, Marathe CS, Lange K, Standfield S, Rayner CK, Jones KL - Physiol Rep (2014)

Bottom Line: Exhaled breath was obtained for analysis of (13)CO2 and calculation of the 50% GE time (T50).Blood glucose, serum insulin and plasma glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic peptide (GIP) were measured, and the insulin sensitivity index (ISI), and the disposition index (DI), were calculated.We conclude that in NGT and IGT, the effect of GE on both the 'early' and 'late' glycemic responses to a 75-g oral glucose load is complementary to that of insulin sensitivity.

View Article: PubMed Central - PubMed

Affiliation: Discipline of Medicine, The University of Adelaide, Adelaide, South Australia, Australia NHMRC Centre of Research Excellence in Translating Nutritional Science to Good Health, The University of Adelaide, Adelaide, South Australia, Australia.

No MeSH data available.


Related in: MedlinePlus

Relationships between the change from baseline for blood glucose between t = 0–180 min and the T50 in (A) all subjects (n = 74, R = 0.55, P < 0.001), (B) NGT group (n = 30, R = 0.73, P < 0.001), and (C) the IGT group (n = 44, R = 0.50, P < 0.001).
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fig04: Relationships between the change from baseline for blood glucose between t = 0–180 min and the T50 in (A) all subjects (n = 74, R = 0.55, P < 0.001), (B) NGT group (n = 30, R = 0.73, P < 0.001), and (C) the IGT group (n = 44, R = 0.50, P < 0.001).

Mentions: In contrast to the rise, in the whole group there was a relationship between the change in blood glucose at t = 180 min (R = 0.55, P < 0.001, Fig. 4A) and the T50. The absolute blood glucose at t = 180 min was also related to the T50 (R = 0.56, P < 0.001). Similarly, in the whole group both the change in (R = 0.54, P < 0.001), and absolute (R = 0.43, P < 0.001) serum insulin at t = 180 min were related to the T50.


Impact of gastric emptying to the glycemic and insulinemic responses to a 75-g oral glucose load in older subjects with normal and impaired glucose tolerance.

Trahair LG, Horowitz M, Marathe CS, Lange K, Standfield S, Rayner CK, Jones KL - Physiol Rep (2014)

Relationships between the change from baseline for blood glucose between t = 0–180 min and the T50 in (A) all subjects (n = 74, R = 0.55, P < 0.001), (B) NGT group (n = 30, R = 0.73, P < 0.001), and (C) the IGT group (n = 44, R = 0.50, P < 0.001).
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4255811&req=5

fig04: Relationships between the change from baseline for blood glucose between t = 0–180 min and the T50 in (A) all subjects (n = 74, R = 0.55, P < 0.001), (B) NGT group (n = 30, R = 0.73, P < 0.001), and (C) the IGT group (n = 44, R = 0.50, P < 0.001).
Mentions: In contrast to the rise, in the whole group there was a relationship between the change in blood glucose at t = 180 min (R = 0.55, P < 0.001, Fig. 4A) and the T50. The absolute blood glucose at t = 180 min was also related to the T50 (R = 0.56, P < 0.001). Similarly, in the whole group both the change in (R = 0.54, P < 0.001), and absolute (R = 0.43, P < 0.001) serum insulin at t = 180 min were related to the T50.

Bottom Line: Exhaled breath was obtained for analysis of (13)CO2 and calculation of the 50% GE time (T50).Blood glucose, serum insulin and plasma glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic peptide (GIP) were measured, and the insulin sensitivity index (ISI), and the disposition index (DI), were calculated.We conclude that in NGT and IGT, the effect of GE on both the 'early' and 'late' glycemic responses to a 75-g oral glucose load is complementary to that of insulin sensitivity.

View Article: PubMed Central - PubMed

Affiliation: Discipline of Medicine, The University of Adelaide, Adelaide, South Australia, Australia NHMRC Centre of Research Excellence in Translating Nutritional Science to Good Health, The University of Adelaide, Adelaide, South Australia, Australia.

No MeSH data available.


Related in: MedlinePlus