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Impact of gastric emptying to the glycemic and insulinemic responses to a 75-g oral glucose load in older subjects with normal and impaired glucose tolerance.

Trahair LG, Horowitz M, Marathe CS, Lange K, Standfield S, Rayner CK, Jones KL - Physiol Rep (2014)

Bottom Line: Exhaled breath was obtained for analysis of (13)CO2 and calculation of the 50% GE time (T50).Blood glucose, serum insulin and plasma glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic peptide (GIP) were measured, and the insulin sensitivity index (ISI), and the disposition index (DI), were calculated.We conclude that in NGT and IGT, the effect of GE on both the 'early' and 'late' glycemic responses to a 75-g oral glucose load is complementary to that of insulin sensitivity.

View Article: PubMed Central - PubMed

Affiliation: Discipline of Medicine, The University of Adelaide, Adelaide, South Australia, Australia NHMRC Centre of Research Excellence in Translating Nutritional Science to Good Health, The University of Adelaide, Adelaide, South Australia, Australia.

No MeSH data available.


Related in: MedlinePlus

Relationships between absolute blood glucose at t = 120 min and the T50 in (A) all subjects (n = 74, R = 0.01, P = NS) and (B) NGT (n = 30, R = 0.34, P = 0.06) and between blood glucose AUC 0–120 min and the T50 in (C) IGT (n = 44, R = −0.34, P < 0.05).
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fig03: Relationships between absolute blood glucose at t = 120 min and the T50 in (A) all subjects (n = 74, R = 0.01, P = NS) and (B) NGT (n = 30, R = 0.34, P = 0.06) and between blood glucose AUC 0–120 min and the T50 in (C) IGT (n = 44, R = −0.34, P < 0.05).

Mentions: In the whole group, there was no relationship between the absolute, change in, or AUC for, blood glucose or serum insulin at t = 120 min and the T50 (Fig. 3A), however, in subjects with NGT there was a trend for a relationship between both the change in blood glucose between t = 0–120 min (R = 0.34, P = 0.06) and the absolute blood glucose at t = 120 min (R = 0.34, P = 0.06, Fig. 3B), but not the AUC for blood glucose at t = 120 min (R = 0.03, P = 0.87) and the T50. In the group with IGT, the AUC for blood glucose (but not the absolute or change in blood glucose) at t = 120 min was related inversely to the T50 (R = −0.34, P < 0.05, Fig. 3C).


Impact of gastric emptying to the glycemic and insulinemic responses to a 75-g oral glucose load in older subjects with normal and impaired glucose tolerance.

Trahair LG, Horowitz M, Marathe CS, Lange K, Standfield S, Rayner CK, Jones KL - Physiol Rep (2014)

Relationships between absolute blood glucose at t = 120 min and the T50 in (A) all subjects (n = 74, R = 0.01, P = NS) and (B) NGT (n = 30, R = 0.34, P = 0.06) and between blood glucose AUC 0–120 min and the T50 in (C) IGT (n = 44, R = −0.34, P < 0.05).
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4255811&req=5

fig03: Relationships between absolute blood glucose at t = 120 min and the T50 in (A) all subjects (n = 74, R = 0.01, P = NS) and (B) NGT (n = 30, R = 0.34, P = 0.06) and between blood glucose AUC 0–120 min and the T50 in (C) IGT (n = 44, R = −0.34, P < 0.05).
Mentions: In the whole group, there was no relationship between the absolute, change in, or AUC for, blood glucose or serum insulin at t = 120 min and the T50 (Fig. 3A), however, in subjects with NGT there was a trend for a relationship between both the change in blood glucose between t = 0–120 min (R = 0.34, P = 0.06) and the absolute blood glucose at t = 120 min (R = 0.34, P = 0.06, Fig. 3B), but not the AUC for blood glucose at t = 120 min (R = 0.03, P = 0.87) and the T50. In the group with IGT, the AUC for blood glucose (but not the absolute or change in blood glucose) at t = 120 min was related inversely to the T50 (R = −0.34, P < 0.05, Fig. 3C).

Bottom Line: Exhaled breath was obtained for analysis of (13)CO2 and calculation of the 50% GE time (T50).Blood glucose, serum insulin and plasma glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic peptide (GIP) were measured, and the insulin sensitivity index (ISI), and the disposition index (DI), were calculated.We conclude that in NGT and IGT, the effect of GE on both the 'early' and 'late' glycemic responses to a 75-g oral glucose load is complementary to that of insulin sensitivity.

View Article: PubMed Central - PubMed

Affiliation: Discipline of Medicine, The University of Adelaide, Adelaide, South Australia, Australia NHMRC Centre of Research Excellence in Translating Nutritional Science to Good Health, The University of Adelaide, Adelaide, South Australia, Australia.

No MeSH data available.


Related in: MedlinePlus