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Impact of gastric emptying to the glycemic and insulinemic responses to a 75-g oral glucose load in older subjects with normal and impaired glucose tolerance.

Trahair LG, Horowitz M, Marathe CS, Lange K, Standfield S, Rayner CK, Jones KL - Physiol Rep (2014)

Bottom Line: Exhaled breath was obtained for analysis of (13)CO2 and calculation of the 50% GE time (T50).Blood glucose, serum insulin and plasma glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic peptide (GIP) were measured, and the insulin sensitivity index (ISI), and the disposition index (DI), were calculated.We conclude that in NGT and IGT, the effect of GE on both the 'early' and 'late' glycemic responses to a 75-g oral glucose load is complementary to that of insulin sensitivity.

View Article: PubMed Central - PubMed

Affiliation: Discipline of Medicine, The University of Adelaide, Adelaide, South Australia, Australia NHMRC Centre of Research Excellence in Translating Nutritional Science to Good Health, The University of Adelaide, Adelaide, South Australia, Australia.

No MeSH data available.


Related in: MedlinePlus

Relationships between the rise in blood glucose between t = 0–60 min and the T50 in (A) all subjects (n = 74, R = −0.30, P < 0.01), (B) NGT (●, n = 30, R = 0.10, P = NS) and IGT (■, n = 44, R = −0.47, P < 0.001).
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fig02: Relationships between the rise in blood glucose between t = 0–60 min and the T50 in (A) all subjects (n = 74, R = −0.30, P < 0.01), (B) NGT (●, n = 30, R = 0.10, P = NS) and IGT (■, n = 44, R = −0.47, P < 0.001).

Mentions: In the whole group (n = 74), there were inverse relationships between rises in both blood glucose (R = −0.30, P < 0.01, Fig. 2A) and serum insulin (R = −0.23, P < 0.05) between t = 0–60 min and the T50. Similarly, there were inverse relationships between the absolute blood glucose (R = −0.27, P < 0.05) and serum insulin (R = −0.23, P < 0.05) at t = 60 min and the T50.


Impact of gastric emptying to the glycemic and insulinemic responses to a 75-g oral glucose load in older subjects with normal and impaired glucose tolerance.

Trahair LG, Horowitz M, Marathe CS, Lange K, Standfield S, Rayner CK, Jones KL - Physiol Rep (2014)

Relationships between the rise in blood glucose between t = 0–60 min and the T50 in (A) all subjects (n = 74, R = −0.30, P < 0.01), (B) NGT (●, n = 30, R = 0.10, P = NS) and IGT (■, n = 44, R = −0.47, P < 0.001).
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4255811&req=5

fig02: Relationships between the rise in blood glucose between t = 0–60 min and the T50 in (A) all subjects (n = 74, R = −0.30, P < 0.01), (B) NGT (●, n = 30, R = 0.10, P = NS) and IGT (■, n = 44, R = −0.47, P < 0.001).
Mentions: In the whole group (n = 74), there were inverse relationships between rises in both blood glucose (R = −0.30, P < 0.01, Fig. 2A) and serum insulin (R = −0.23, P < 0.05) between t = 0–60 min and the T50. Similarly, there were inverse relationships between the absolute blood glucose (R = −0.27, P < 0.05) and serum insulin (R = −0.23, P < 0.05) at t = 60 min and the T50.

Bottom Line: Exhaled breath was obtained for analysis of (13)CO2 and calculation of the 50% GE time (T50).Blood glucose, serum insulin and plasma glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic peptide (GIP) were measured, and the insulin sensitivity index (ISI), and the disposition index (DI), were calculated.We conclude that in NGT and IGT, the effect of GE on both the 'early' and 'late' glycemic responses to a 75-g oral glucose load is complementary to that of insulin sensitivity.

View Article: PubMed Central - PubMed

Affiliation: Discipline of Medicine, The University of Adelaide, Adelaide, South Australia, Australia NHMRC Centre of Research Excellence in Translating Nutritional Science to Good Health, The University of Adelaide, Adelaide, South Australia, Australia.

No MeSH data available.


Related in: MedlinePlus