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Impact of gastric emptying to the glycemic and insulinemic responses to a 75-g oral glucose load in older subjects with normal and impaired glucose tolerance.

Trahair LG, Horowitz M, Marathe CS, Lange K, Standfield S, Rayner CK, Jones KL - Physiol Rep (2014)

Bottom Line: Exhaled breath was obtained for analysis of (13)CO2 and calculation of the 50% GE time (T50).Blood glucose, serum insulin and plasma glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic peptide (GIP) were measured, and the insulin sensitivity index (ISI), and the disposition index (DI), were calculated.We conclude that in NGT and IGT, the effect of GE on both the 'early' and 'late' glycemic responses to a 75-g oral glucose load is complementary to that of insulin sensitivity.

View Article: PubMed Central - PubMed

Affiliation: Discipline of Medicine, The University of Adelaide, Adelaide, South Australia, Australia NHMRC Centre of Research Excellence in Translating Nutritional Science to Good Health, The University of Adelaide, Adelaide, South Australia, Australia.

No MeSH data available.


Related in: MedlinePlus

Blood glucose (A), serum insulin (B), plasma GLP‐1 (C), and plasma GIP (D) immediately before and after a 75‐g oral glucose load in all subjects (▲, n = 77), subjects with normal glucose tolerance (●, n = 31) and those with impaired glucose tolerance (± impaired fasting glucose) (■, n = 46) (*P < 0.05 NGT vs. IGT).
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fig01: Blood glucose (A), serum insulin (B), plasma GLP‐1 (C), and plasma GIP (D) immediately before and after a 75‐g oral glucose load in all subjects (▲, n = 77), subjects with normal glucose tolerance (●, n = 31) and those with impaired glucose tolerance (± impaired fasting glucose) (■, n = 46) (*P < 0.05 NGT vs. IGT).

Mentions: Blood glucose increased following the drink (P < 0.001) and was less than baseline at both t = 180 and 240 min (P < 0.001 for both) (Fig. 1A). In the group with IGT when compared with those with NGT, blood glucose was greater at baseline, t = 15, 30, 45, 60, 90, 120, and 180 min (P < 0.05 for all), but not at t = 240 min (P = 0.34), and the AUC for blood glucose was greater at t = 60, 120, 180, and 240 min (P < 0.001 for all) (Fig. 1A).


Impact of gastric emptying to the glycemic and insulinemic responses to a 75-g oral glucose load in older subjects with normal and impaired glucose tolerance.

Trahair LG, Horowitz M, Marathe CS, Lange K, Standfield S, Rayner CK, Jones KL - Physiol Rep (2014)

Blood glucose (A), serum insulin (B), plasma GLP‐1 (C), and plasma GIP (D) immediately before and after a 75‐g oral glucose load in all subjects (▲, n = 77), subjects with normal glucose tolerance (●, n = 31) and those with impaired glucose tolerance (± impaired fasting glucose) (■, n = 46) (*P < 0.05 NGT vs. IGT).
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4255811&req=5

fig01: Blood glucose (A), serum insulin (B), plasma GLP‐1 (C), and plasma GIP (D) immediately before and after a 75‐g oral glucose load in all subjects (▲, n = 77), subjects with normal glucose tolerance (●, n = 31) and those with impaired glucose tolerance (± impaired fasting glucose) (■, n = 46) (*P < 0.05 NGT vs. IGT).
Mentions: Blood glucose increased following the drink (P < 0.001) and was less than baseline at both t = 180 and 240 min (P < 0.001 for both) (Fig. 1A). In the group with IGT when compared with those with NGT, blood glucose was greater at baseline, t = 15, 30, 45, 60, 90, 120, and 180 min (P < 0.05 for all), but not at t = 240 min (P = 0.34), and the AUC for blood glucose was greater at t = 60, 120, 180, and 240 min (P < 0.001 for all) (Fig. 1A).

Bottom Line: Exhaled breath was obtained for analysis of (13)CO2 and calculation of the 50% GE time (T50).Blood glucose, serum insulin and plasma glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic peptide (GIP) were measured, and the insulin sensitivity index (ISI), and the disposition index (DI), were calculated.We conclude that in NGT and IGT, the effect of GE on both the 'early' and 'late' glycemic responses to a 75-g oral glucose load is complementary to that of insulin sensitivity.

View Article: PubMed Central - PubMed

Affiliation: Discipline of Medicine, The University of Adelaide, Adelaide, South Australia, Australia NHMRC Centre of Research Excellence in Translating Nutritional Science to Good Health, The University of Adelaide, Adelaide, South Australia, Australia.

No MeSH data available.


Related in: MedlinePlus