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Differential contribution of ACh-muscarinic and β-adrenergic receptors to vasodilatation in noncontracting muscle during voluntary one-legged exercise.

Ishii K, Matsukawa K, Liang N, Endo K, Idesako M, Hamada H, Kataoka T, Ueno K, Watanabe T, Takahashi M - Physiol Rep (2014)

Bottom Line: Propranolol also failed to affect the initial increases in femoral blood flow and vascular conductance of nonexercising leg but significantly attenuated (P < 0.05) their later increases during exercise.Subsequent atropine (10-15 μg/kg iv) abolished the initial increases in Oxy-Hb of both VL muscles.It is likely that the rapid cholinergic and delayed β-adrenergic vasodilator mechanisms cooperate to increase muscle blood flow during exercise.

View Article: PubMed Central - PubMed

Affiliation: Department of Integrative Physiology, Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima, Japan.

No MeSH data available.


Related in: MedlinePlus

The effects of propranolol and subsequent atropine on the changes in HR, MAP, and Oxy‐Hb of bilateral VL muscles and the vividness score during cycling‐ and circle‐imagery (n = 10 subjects). CON, control condition (□). PROP, propranolol condition (). ATR+PROP, atropine and propranolol condition (■). *Significant difference (P <0.05) from the baseline. †Significant difference (P <0.05) among the three conditions (CON vs. PROP vs. ATR+PROP). N.S., not significant (P >0.05).
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fig05: The effects of propranolol and subsequent atropine on the changes in HR, MAP, and Oxy‐Hb of bilateral VL muscles and the vividness score during cycling‐ and circle‐imagery (n = 10 subjects). CON, control condition (□). PROP, propranolol condition (). ATR+PROP, atropine and propranolol condition (■). *Significant difference (P <0.05) from the baseline. †Significant difference (P <0.05) among the three conditions (CON vs. PROP vs. ATR+PROP). N.S., not significant (P >0.05).

Mentions: Figure 4 exemplifies typical responses of HR, AP, and the Oxy‐Hb of the right and left VL muscles during mental imagery of the one‐legged cycling in a subject. Cycling imagery induced bilateral increases in Oxy‐Hb without changing AP as previously reported (Ishii et al. 2012, 2013). The increases in Oxy‐Hb were not affected by propranolol but abolished by subsequent atropine and propranolol. Figure 5 summarizes the effects of propranolol and subsequent atropine and propranolol on the imagery‐induced cardiovascular and Oxy‐Hb responses. Slight tachycardia observed during cycling imagery was blunted (P <0.05) by propranolol and abolished by subsequent atropine and propranolol. The increases in Oxy‐Hb of the bilateral muscles during cycling imagery were not significantly affected by propranolol but abolished by subsequent atropine and propranolol. MAP did not change significantly from the baseline level during the cycling imagery in all conditions. On the other hand, circle‐imagery did not cause any rises in HR and the Oxy‐Hb in bilateral VL muscles irrespective of the presence or absence of the drugs, although a slight rise in MAP was recognized following subsequent atropine and propranolol. The vividness score was not different between the two kinds of imagery and was the same irrespective of the presence or absence of the drugs (Fig. 5).


Differential contribution of ACh-muscarinic and β-adrenergic receptors to vasodilatation in noncontracting muscle during voluntary one-legged exercise.

Ishii K, Matsukawa K, Liang N, Endo K, Idesako M, Hamada H, Kataoka T, Ueno K, Watanabe T, Takahashi M - Physiol Rep (2014)

The effects of propranolol and subsequent atropine on the changes in HR, MAP, and Oxy‐Hb of bilateral VL muscles and the vividness score during cycling‐ and circle‐imagery (n = 10 subjects). CON, control condition (□). PROP, propranolol condition (). ATR+PROP, atropine and propranolol condition (■). *Significant difference (P <0.05) from the baseline. †Significant difference (P <0.05) among the three conditions (CON vs. PROP vs. ATR+PROP). N.S., not significant (P >0.05).
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4255809&req=5

fig05: The effects of propranolol and subsequent atropine on the changes in HR, MAP, and Oxy‐Hb of bilateral VL muscles and the vividness score during cycling‐ and circle‐imagery (n = 10 subjects). CON, control condition (□). PROP, propranolol condition (). ATR+PROP, atropine and propranolol condition (■). *Significant difference (P <0.05) from the baseline. †Significant difference (P <0.05) among the three conditions (CON vs. PROP vs. ATR+PROP). N.S., not significant (P >0.05).
Mentions: Figure 4 exemplifies typical responses of HR, AP, and the Oxy‐Hb of the right and left VL muscles during mental imagery of the one‐legged cycling in a subject. Cycling imagery induced bilateral increases in Oxy‐Hb without changing AP as previously reported (Ishii et al. 2012, 2013). The increases in Oxy‐Hb were not affected by propranolol but abolished by subsequent atropine and propranolol. Figure 5 summarizes the effects of propranolol and subsequent atropine and propranolol on the imagery‐induced cardiovascular and Oxy‐Hb responses. Slight tachycardia observed during cycling imagery was blunted (P <0.05) by propranolol and abolished by subsequent atropine and propranolol. The increases in Oxy‐Hb of the bilateral muscles during cycling imagery were not significantly affected by propranolol but abolished by subsequent atropine and propranolol. MAP did not change significantly from the baseline level during the cycling imagery in all conditions. On the other hand, circle‐imagery did not cause any rises in HR and the Oxy‐Hb in bilateral VL muscles irrespective of the presence or absence of the drugs, although a slight rise in MAP was recognized following subsequent atropine and propranolol. The vividness score was not different between the two kinds of imagery and was the same irrespective of the presence or absence of the drugs (Fig. 5).

Bottom Line: Propranolol also failed to affect the initial increases in femoral blood flow and vascular conductance of nonexercising leg but significantly attenuated (P < 0.05) their later increases during exercise.Subsequent atropine (10-15 μg/kg iv) abolished the initial increases in Oxy-Hb of both VL muscles.It is likely that the rapid cholinergic and delayed β-adrenergic vasodilator mechanisms cooperate to increase muscle blood flow during exercise.

View Article: PubMed Central - PubMed

Affiliation: Department of Integrative Physiology, Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima, Japan.

No MeSH data available.


Related in: MedlinePlus