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Ischemia-reperfusion injury and hypoglycemia risk in insulin-treated T1DM rats following different modalities of regular exercise.

McDonald MW, Hall KE, Jiang M, Noble EG, Melling CW - Physiol Rep (2014)

Bottom Line: The purpose of this study was to investigate the cardiovascular benefit of different regular exercise regimes, while monitoring blood glucose concentrations during the post-exercise period.The cardiovascular benefit of each exercise program was determined by the myocardial recovery from ischemia-reperfusion injury.Each exercise modality caused a significant decline in blood glucose in the post-exercise period; however, blood glucose levels did not reach hypoglycemic concentrations (<3.0 mmol/L) throughout the exercise intervention.

View Article: PubMed Central - PubMed

Affiliation: School of Kinesiology, Faculty of Health Sciences, University of Western Ontario, London, Ontario, Canada.

No MeSH data available.


Related in: MedlinePlus

Two hour post‐exercise blood glucose measures. Blood glucose was measured in (A) DR (B) DL and (C) DH every 15 min for 2 h post‐exercise. DR and DH demonstrated no significant difference in post‐exercise blood glucose response at week 3 and week 6; DL demonstrated an attenuated blood glucose response at week 6 compared to week 3 (P < 0.05). An asterisk (*) indicates a significant difference in blood glucose from pre‐exercise (PRE) at week 3 of exercise training based on the post hoc test (P < 0.05). A cross (†) indicates a significant difference in blood glucose from pre‐exercise (PRE) at week 6 of exercise training based on the post hoc test (P < 0.05). Data presented as a mean ± SE.
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fig04: Two hour post‐exercise blood glucose measures. Blood glucose was measured in (A) DR (B) DL and (C) DH every 15 min for 2 h post‐exercise. DR and DH demonstrated no significant difference in post‐exercise blood glucose response at week 3 and week 6; DL demonstrated an attenuated blood glucose response at week 6 compared to week 3 (P < 0.05). An asterisk (*) indicates a significant difference in blood glucose from pre‐exercise (PRE) at week 3 of exercise training based on the post hoc test (P < 0.05). A cross (†) indicates a significant difference in blood glucose from pre‐exercise (PRE) at week 6 of exercise training based on the post hoc test (P < 0.05). Data presented as a mean ± SE.

Mentions: At week three, blood glucose concentrations in DR animals declined slowly following the exercise, reaching significantly lower concentrations (vs. pre‐exercise) at 45 min post‐exercise, and remained significantly lower until 110 min post‐exercise (Fig. 4A; P < 0.05). In DL and DH animals, the decline in blood glucose concentrations in response to exercise during week three was evident immediately following the exercise session (Fig. 4B and C; P < 0.05). The reduction in blood glucose concentrations of DL rats remained significantly lower (vs. pre‐exercise) at 120 min post‐exercise, while DH rats returned to pre‐exercise blood glucose concentrations by 90 min post‐exercise (P < 0.05). At week six of training, DR rats demonstrated a delayed blood glucose reduction in response to exercise in comparison to the week three exercise session, whereby a significant drop in blood glucose was not evident until 60 min post‐exercise (P < 0.05). Similarly, DH rats demonstrated an altered blood glucose response to exercise at week six, exhibiting a quicker return to pre‐exercise blood glucose concentrations by 60 min (P < 0.05). At week six, a drop in blood glucose was absent in DL rats, but rather an increase in blood glucose was evident at 30, 105, and 120 min post‐exercise (P < 0.05).


Ischemia-reperfusion injury and hypoglycemia risk in insulin-treated T1DM rats following different modalities of regular exercise.

McDonald MW, Hall KE, Jiang M, Noble EG, Melling CW - Physiol Rep (2014)

Two hour post‐exercise blood glucose measures. Blood glucose was measured in (A) DR (B) DL and (C) DH every 15 min for 2 h post‐exercise. DR and DH demonstrated no significant difference in post‐exercise blood glucose response at week 3 and week 6; DL demonstrated an attenuated blood glucose response at week 6 compared to week 3 (P < 0.05). An asterisk (*) indicates a significant difference in blood glucose from pre‐exercise (PRE) at week 3 of exercise training based on the post hoc test (P < 0.05). A cross (†) indicates a significant difference in blood glucose from pre‐exercise (PRE) at week 6 of exercise training based on the post hoc test (P < 0.05). Data presented as a mean ± SE.
© Copyright Policy - open-access
Related In: Results  -  Collection

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Show All Figures
getmorefigures.php?uid=PMC4255808&req=5

fig04: Two hour post‐exercise blood glucose measures. Blood glucose was measured in (A) DR (B) DL and (C) DH every 15 min for 2 h post‐exercise. DR and DH demonstrated no significant difference in post‐exercise blood glucose response at week 3 and week 6; DL demonstrated an attenuated blood glucose response at week 6 compared to week 3 (P < 0.05). An asterisk (*) indicates a significant difference in blood glucose from pre‐exercise (PRE) at week 3 of exercise training based on the post hoc test (P < 0.05). A cross (†) indicates a significant difference in blood glucose from pre‐exercise (PRE) at week 6 of exercise training based on the post hoc test (P < 0.05). Data presented as a mean ± SE.
Mentions: At week three, blood glucose concentrations in DR animals declined slowly following the exercise, reaching significantly lower concentrations (vs. pre‐exercise) at 45 min post‐exercise, and remained significantly lower until 110 min post‐exercise (Fig. 4A; P < 0.05). In DL and DH animals, the decline in blood glucose concentrations in response to exercise during week three was evident immediately following the exercise session (Fig. 4B and C; P < 0.05). The reduction in blood glucose concentrations of DL rats remained significantly lower (vs. pre‐exercise) at 120 min post‐exercise, while DH rats returned to pre‐exercise blood glucose concentrations by 90 min post‐exercise (P < 0.05). At week six of training, DR rats demonstrated a delayed blood glucose reduction in response to exercise in comparison to the week three exercise session, whereby a significant drop in blood glucose was not evident until 60 min post‐exercise (P < 0.05). Similarly, DH rats demonstrated an altered blood glucose response to exercise at week six, exhibiting a quicker return to pre‐exercise blood glucose concentrations by 60 min (P < 0.05). At week six, a drop in blood glucose was absent in DL rats, but rather an increase in blood glucose was evident at 30, 105, and 120 min post‐exercise (P < 0.05).

Bottom Line: The purpose of this study was to investigate the cardiovascular benefit of different regular exercise regimes, while monitoring blood glucose concentrations during the post-exercise period.The cardiovascular benefit of each exercise program was determined by the myocardial recovery from ischemia-reperfusion injury.Each exercise modality caused a significant decline in blood glucose in the post-exercise period; however, blood glucose levels did not reach hypoglycemic concentrations (<3.0 mmol/L) throughout the exercise intervention.

View Article: PubMed Central - PubMed

Affiliation: School of Kinesiology, Faculty of Health Sciences, University of Western Ontario, London, Ontario, Canada.

No MeSH data available.


Related in: MedlinePlus